Reviewed, UniProtKB/Swiss-Prot Q0P570 (ERG19_BOVIN)

Names and origin

Protein names

Recommended name:
    Diphosphomevalonate decarboxylase
    EC=4.1.1.33
Alternative name(s):
    Mevalonate pyrophosphate decarboxylase
    Mevalonate (diphospho)decarboxylase

Gene names

Name:

MVD

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Performs the first committed step in the biosynthesis of isoprenes By similarity.
Catalytic activity	ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2.
Pathway	Steroid biosynthesis; cholesterol biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the diphosphomevalonate decarboxylase family.

Ontologies

Keywords
Biological process	Cholesterol biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Lyase
Gene Ontology (GO)
Biological process	cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW diphosphomevalonate decarboxylase activity Inferred from electronic annotation. Source: EC kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Diphosphomevalonate decarboxylase		PRO_0000310437

Sequences

	Sequence		Length	Mass (Da)
	Q0P570-1 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: C659D6635C9EF49B	FASTA	400	43,732
	10 20 30 40 50 60 MASEKPIVVV TCTAPVNIAV VKYWGKRDEE LILPINSSLS VTLHQDQLKT TTTAAISRDF 70 80 90 100 110 120 TEDRIWLNGR EEDMGHPRLQ ACLREIRRLA RKRRSDGHED PLPLSLSYKV HVASENNFPT 130 140 150 160 170 180 AAGLASSAAG YACLAYTLAR VYGVDSDLSE VARRGSGSAC RSLYGGFVEW QMGERPDGKD 190 200 210 220 230 240 SVACQVAPES HWPELRVLIL VVSAERKPMG STAGMQTSVE TSALLKFRAE ALVPPRMAEM 250 260 270 280 290 300 TRCIRERNFQ AFGQLTMKDS NQFHATCLDT FPPISYLSDT SRRIIQLVHR FNAHHGQTKV 310 320 330 340 350 360 AYTFDAGPNA VVFTLDDTVA EFVAAVRHSF PPESNGDKFL KGLPVEPVLL SDELKAVLGM 370 380 390 400 DPVPGSIRYI IATQVGPGPQ VLDDPGAHLL GPDGLPKPAA

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal muscle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC120432 mRNA. Translation: AAI20433.1.
IPI	IPI00690789.
RefSeq	NP_001068892.1.
UniGene	Bt.3884
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000012059. Bos taurus. [Contig view]
GeneID	509958.
KEGG	bta:509958.
Phylogenomic databases
HOVERGEN	Q0P570.
Enzyme and pathway databases
BRENDA	4.1.1.33. 251.
Family and domain databases
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR005935. Mev_diP_decarb. [Graphical view]
PANTHER	PTHR10977. Mev_diP_decarb. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF015950. Mev_P_decrbx. 1 hit.
TIGRFAMs	TIGR01240. mevDPdecarb. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ERG19_BOVIN

Accession

Primary (citable) accession number: Q0P570

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	September 19, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)