Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gastric inhibitory polypeptide receptor

Gene

Gipr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

  • gastric inhibitory peptide receptor activity Source: Ensembl
  • signaling receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide receptor
Short name:
GIP-R
Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor
Gene namesi
Name:Gipr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1352753 Gipr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 134ExtracellularSequence analysisAdd BLAST116
Transmembranei135 – 155Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini156 – 222CytoplasmicSequence analysisAdd BLAST67
Transmembranei223 – 243Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini244 – 255ExtracellularSequence analysisAdd BLAST12
Transmembranei256 – 276Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini277 – 297CytoplasmicSequence analysisAdd BLAST21
Transmembranei298 – 318Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini319 – 337ExtracellularSequence analysisAdd BLAST19
Transmembranei338 – 358Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini359 – 370CytoplasmicSequence analysisAdd BLAST12
Transmembranei371 – 391Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini392 – 460ExtracellularSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000030625119 – 460Gastric inhibitory polypeptide receptorAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 66By similarity
Disulfide bondi57 ↔ 99By similarity
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 114By similarity

Post-translational modificationi

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ0P543
PRIDEiQ0P543

PTM databases

PhosphoSitePlusiQ0P543

Expressioni

Gene expression databases

BgeeiENSMUSG00000030406
CleanExiMM_GIPR
ExpressionAtlasiQ0P543 baseline and differential
GenevisibleiQ0P543 MM

Interactioni

Subunit structurei

May form homodimers and heterodimers with GLP1R.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092384

Structurei

3D structure databases

ProteinModelPortaliQ0P543
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiQ0P543
KOiK04580
OMAiSFDMYVC
OrthoDBiEOG091G0NF8
PhylomeDBiQ0P543
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR001749 GPCR_2_GIP_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01129 GIPRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0P543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE
60 70 80 90 100
PPSGLACNGS FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG
110 120 130 140 150
SDGQWGSWRD HTQCENPEKN GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL
160 170 180 190 200
ALLILSLFRR LHCTRNYIHM NLFTSFMLRA AAILTRDQLL PPLGPYTGDQ
210 220 230 240 250
APTPWNQALA ACRTAQIMTQ YCVGANYTWL LVEGVYLHHL LVIVGRSEKG
260 270 280 290 300
HFRCYLLLGW GAPALFVIPW VIVRYLRENT QCWERNEVKA IWWIIRTPIL
310 320 330 340 350
ITILINFLIF IRILGILVSK LRTRQMRCPD YRLRLARSTL TLVPLLGVHE
360 370 380 390 400
VVFAPVTEEQ VEGSLRFAKL AFEIFLSSFQ GFLVSVLYCF INKEVQSEIR
410 420 430 440 450
QGWRHRRLRL SLQEQRPRPH QELAPRAVPL SSACREAAVG NALPSGMLHV
460
PGDEVLESYC
Length:460
Mass (Da):52,992
Last modified:October 2, 2007 - v2
Checksum:i41ABC3F1E0A7DF98
GO
Isoform 2 (identifier: Q0P543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-230: ALAACRTAQIMTQYCVGANYTWL → VLHRLLPGGTKTFPIYFRTFPHH
     231-460: Missing.

Show »
Length:230
Mass (Da):26,617
Checksum:iAA4800B55C77468E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122A → V in AAO85080 (PubMed:12679517).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028433208 – 230ALAAC…NYTWL → VLHRLLPGGTKTFPIYFRTF PHH in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_028434231 – 460Missing in isoform 2. 1 PublicationAdd BLAST230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145199 Genomic DNA No translation available.
BC120671 mRNA Translation: AAI20672.1
BC120673 mRNA Translation: AAI20674.1
AY255568 mRNA Translation: AAO85080.1
CCDSiCCDS39795.1 [Q0P543-1]
RefSeqiNP_001074284.1, NM_001080815.1 [Q0P543-1]
UniGeneiMm.333633

Genome annotation databases

EnsembliENSMUST00000094790; ENSMUSP00000092384; ENSMUSG00000030406 [Q0P543-1]
GeneIDi381853
KEGGimmu:381853
UCSCiuc009fkw.1 mouse [Q0P543-1]
uc009fkx.1 mouse [Q0P543-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGIPR_MOUSE
AccessioniPrimary (citable) accession number: Q0P543
Secondary accession number(s): Q80UB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health