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Q0P543 (GIPR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gastric inhibitory polypeptide receptor

Short name=GIP-R
Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor
Gene names
Name:Gipr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase By similarity.

Subunit structure

May form homodimers and heterodimers with GLP1R By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdesensitization of G-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: Ensembl

endocrine pancreas development

Inferred from mutant phenotype PubMed 21270265. Source: MGI

neuropeptide signaling pathway

Traceable author statement PubMed 10611300. Source: MGI

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

response to axon injury

Inferred from electronic annotation. Source: Ensembl

response to calcium ion

Inferred from electronic annotation. Source: Ensembl

response to fatty acid

Inferred from electronic annotation. Source: Ensembl

response to glucose

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiongastric inhibitory peptide receptor activity

Inferred from electronic annotation. Source: Ensembl

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

receptor activity

Traceable author statement PubMed 10611300. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0P543-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0P543-2)

The sequence of this isoform differs from the canonical sequence as follows:
     208-230: ALAACRTAQIMTQYCVGANYTWL → VLHRLLPGGTKTFPIYFRTFPHH
     231-460: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 460442Gastric inhibitory polypeptide receptor
PRO_0000306251

Regions

Topological domain19 – 134116Extracellular Potential
Transmembrane135 – 15521Helical; Name=1; Potential
Topological domain156 – 22267Cytoplasmic Potential
Transmembrane223 – 24321Helical; Name=2; Potential
Topological domain244 – 25512Extracellular Potential
Transmembrane256 – 27621Helical; Name=3; Potential
Topological domain277 – 29721Cytoplasmic Potential
Transmembrane298 – 31821Helical; Name=4; Potential
Topological domain319 – 33719Extracellular Potential
Transmembrane338 – 35821Helical; Name=5; Potential
Topological domain359 – 37012Cytoplasmic Potential
Transmembrane371 – 39121Helical; Name=6; Potential
Topological domain392 – 46069Extracellular Potential

Amino acid modifications

Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation731N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 66 By similarity
Disulfide bond57 ↔ 99 By similarity
Disulfide bond80 ↔ 114 By similarity

Natural variations

Alternative sequence208 – 23023ALAAC…NYTWL → VLHRLLPGGTKTFPIYFRTF PHH in isoform 2.
VSP_028433
Alternative sequence231 – 460230Missing in isoform 2.
VSP_028434

Experimental info

Sequence conflict1221A → V in AAO85080. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: 41ABC3F1E0A7DF98

FASTA46052,992
        10         20         30         40         50         60 
MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE PPSGLACNGS 

        70         80         90        100        110        120 
FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG SDGQWGSWRD HTQCENPEKN 

       130        140        150        160        170        180 
GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL ALLILSLFRR LHCTRNYIHM NLFTSFMLRA 

       190        200        210        220        230        240 
AAILTRDQLL PPLGPYTGDQ APTPWNQALA ACRTAQIMTQ YCVGANYTWL LVEGVYLHHL 

       250        260        270        280        290        300 
LVIVGRSEKG HFRCYLLLGW GAPALFVIPW VIVRYLRENT QCWERNEVKA IWWIIRTPIL 

       310        320        330        340        350        360 
ITILINFLIF IRILGILVSK LRTRQMRCPD YRLRLARSTL TLVPLLGVHE VVFAPVTEEQ 

       370        380        390        400        410        420 
VEGSLRFAKL AFEIFLSSFQ GFLVSVLYCF INKEVQSEIR QGWRHRRLRL SLQEQRPRPH 

       430        440        450        460 
QELAPRAVPL SSACREAAVG NALPSGMLHV PGDEVLESYC 

« Hide

Isoform 2 [UniParc].

Checksum: AA4800B55C77468E
Show »

FASTA23026,617

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-178.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC145199 Genomic DNA. No translation available.
BC120671 mRNA. Translation: AAI20672.1.
BC120673 mRNA. Translation: AAI20674.1.
AY255568 mRNA. Translation: AAO85080.1.
RefSeqNP_001074284.1. NM_001080815.1.
UniGeneMm.333633.

3D structure databases

ProteinModelPortalQ0P543.
SMRQ0P543. Positions 27-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000092384.

Chemistry

GuidetoPHARMACOLOGY248.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ0P543.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000094790; ENSMUSP00000092384; ENSMUSG00000030406. [Q0P543-1]
GeneID381853.
KEGGmmu:381853.
UCSCuc009fkw.1. mouse. [Q0P543-1]
uc009fkx.1. mouse. [Q0P543-2]

Organism-specific databases

CTD2696.
MGIMGI:1352753. Gipr.

Phylogenomic databases

eggNOGNOG239460.
GeneTreeENSGT00740000115231.
HOGENOMHOG000008250.
HOVERGENHBG008318.
InParanoidQ0P543.
KOK04580.
OMATRQMRCP.
OrthoDBEOG7TF78W.
PhylomeDBQ0P543.
TreeFamTF315710.

Gene expression databases

BgeeQ0P543.
CleanExMM_GIPR.
GenevestigatorQ0P543.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio402687.
PROQ0P543.
SOURCESearch...

Entry information

Entry nameGIPR_MOUSE
AccessionPrimary (citable) accession number: Q0P543
Secondary accession number(s): Q80UB4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 16, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries