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Q0P543

- GIPR_MOUSE

UniProt

Q0P543 - GIPR_MOUSE

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Protein

Gastric inhibitory polypeptide receptor

Gene

Gipr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

  1. gastric inhibitory peptide receptor activity Source: Ensembl
  2. peptide hormone binding Source: Ensembl
  3. receptor activity Source: MGI

GO - Biological processi

  1. desensitization of G-protein coupled receptor protein signaling pathway Source: Ensembl
  2. endocrine pancreas development Source: MGI
  3. neuropeptide signaling pathway Source: MGI
  4. positive regulation of cAMP biosynthetic process Source: Ensembl
  5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  6. positive regulation of insulin secretion Source: Ensembl
  7. response to axon injury Source: Ensembl
  8. response to calcium ion Source: Ensembl
  9. response to fatty acid Source: Ensembl
  10. response to glucose Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide receptor
Short name:
GIP-R
Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor
Gene namesi
Name:Gipr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352753. Gipr.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 460442Gastric inhibitory polypeptide receptorPRO_0000306251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 66By similarity
Disulfide bondi57 ↔ 99By similarity
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi80 ↔ 114By similarity

Post-translational modificationi

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ0P543.

Expressioni

Gene expression databases

BgeeiQ0P543.
CleanExiMM_GIPR.
GenevestigatoriQ0P543.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GLP1R.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092384.

Structurei

3D structure databases

ProteinModelPortaliQ0P543.
SMRiQ0P543. Positions 27-118, 133-398.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 134116ExtracellularSequence AnalysisAdd
BLAST
Topological domaini156 – 22267CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini244 – 25512ExtracellularSequence AnalysisAdd
BLAST
Topological domaini277 – 29721CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini319 – 33719ExtracellularSequence AnalysisAdd
BLAST
Topological domaini359 – 37012CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini392 – 46069ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei371 – 39121Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239460.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiQ0P543.
KOiK04580.
OMAiTRQMRCP.
OrthoDBiEOG7TF78W.
PhylomeDBiQ0P543.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q0P543-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE
60 70 80 90 100
PPSGLACNGS FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG
110 120 130 140 150
SDGQWGSWRD HTQCENPEKN GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL
160 170 180 190 200
ALLILSLFRR LHCTRNYIHM NLFTSFMLRA AAILTRDQLL PPLGPYTGDQ
210 220 230 240 250
APTPWNQALA ACRTAQIMTQ YCVGANYTWL LVEGVYLHHL LVIVGRSEKG
260 270 280 290 300
HFRCYLLLGW GAPALFVIPW VIVRYLRENT QCWERNEVKA IWWIIRTPIL
310 320 330 340 350
ITILINFLIF IRILGILVSK LRTRQMRCPD YRLRLARSTL TLVPLLGVHE
360 370 380 390 400
VVFAPVTEEQ VEGSLRFAKL AFEIFLSSFQ GFLVSVLYCF INKEVQSEIR
410 420 430 440 450
QGWRHRRLRL SLQEQRPRPH QELAPRAVPL SSACREAAVG NALPSGMLHV
460
PGDEVLESYC
Length:460
Mass (Da):52,992
Last modified:October 2, 2007 - v2
Checksum:i41ABC3F1E0A7DF98
GO
Isoform 2 (identifier: Q0P543-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-230: ALAACRTAQIMTQYCVGANYTWL → VLHRLLPGGTKTFPIYFRTFPHH
     231-460: Missing.

Show »
Length:230
Mass (Da):26,617
Checksum:iAA4800B55C77468E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221A → V in AAO85080. (PubMed:12679517)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei208 – 23023ALAAC…NYTWL → VLHRLLPGGTKTFPIYFRTF PHH in isoform 2. 1 PublicationVSP_028433Add
BLAST
Alternative sequencei231 – 460230Missing in isoform 2. 1 PublicationVSP_028434Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC145199 Genomic DNA. No translation available.
BC120671 mRNA. Translation: AAI20672.1.
BC120673 mRNA. Translation: AAI20674.1.
AY255568 mRNA. Translation: AAO85080.1.
CCDSiCCDS39795.1. [Q0P543-1]
RefSeqiNP_001074284.1. NM_001080815.1. [Q0P543-1]
UniGeneiMm.333633.

Genome annotation databases

EnsembliENSMUST00000094790; ENSMUSP00000092384; ENSMUSG00000030406. [Q0P543-1]
GeneIDi381853.
KEGGimmu:381853.
UCSCiuc009fkw.1. mouse. [Q0P543-1]
uc009fkx.1. mouse. [Q0P543-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC145199 Genomic DNA. No translation available.
BC120671 mRNA. Translation: AAI20672.1 .
BC120673 mRNA. Translation: AAI20674.1 .
AY255568 mRNA. Translation: AAO85080.1 .
CCDSi CCDS39795.1. [Q0P543-1 ]
RefSeqi NP_001074284.1. NM_001080815.1. [Q0P543-1 ]
UniGenei Mm.333633.

3D structure databases

ProteinModelPortali Q0P543.
SMRi Q0P543. Positions 27-118, 133-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000092384.

Chemistry

GuidetoPHARMACOLOGYi 248.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q0P543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000094790 ; ENSMUSP00000092384 ; ENSMUSG00000030406 . [Q0P543-1 ]
GeneIDi 381853.
KEGGi mmu:381853.
UCSCi uc009fkw.1. mouse. [Q0P543-1 ]
uc009fkx.1. mouse. [Q0P543-2 ]

Organism-specific databases

CTDi 2696.
MGIi MGI:1352753. Gipr.

Phylogenomic databases

eggNOGi NOG239460.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
InParanoidi Q0P543.
KOi K04580.
OMAi TRQMRCP.
OrthoDBi EOG7TF78W.
PhylomeDBi Q0P543.
TreeFami TF315710.

Miscellaneous databases

NextBioi 402687.
PROi Q0P543.
SOURCEi Search...

Gene expression databases

Bgeei Q0P543.
CleanExi MM_GIPR.
Genevestigatori Q0P543.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-178.

Entry informationi

Entry nameiGIPR_MOUSE
AccessioniPrimary (citable) accession number: Q0P543
Secondary accession number(s): Q80UB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3