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Q0P543

- GIPR_MOUSE

UniProt

Q0P543 - GIPR_MOUSE

Protein

Gastric inhibitory polypeptide receptor

Gene

Gipr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase By similarity.By similarity

    GO - Molecular functioni

    1. gastric inhibitory peptide receptor activity Source: Ensembl
    2. peptide hormone binding Source: Ensembl
    3. receptor activity Source: MGI

    GO - Biological processi

    1. desensitization of G-protein coupled receptor protein signaling pathway Source: Ensembl
    2. endocrine pancreas development Source: MGI
    3. neuropeptide signaling pathway Source: MGI
    4. positive regulation of cAMP biosynthetic process Source: Ensembl
    5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    6. positive regulation of insulin secretion Source: Ensembl
    7. response to axon injury Source: Ensembl
    8. response to calcium ion Source: Ensembl
    9. response to fatty acid Source: Ensembl
    10. response to glucose Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastric inhibitory polypeptide receptor
    Short name:
    GIP-R
    Alternative name(s):
    Glucose-dependent insulinotropic polypeptide receptor
    Gene namesi
    Name:Gipr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1352753. Gipr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 460442Gastric inhibitory polypeptide receptorPRO_0000306251Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi42 ↔ 66By similarity
    Disulfide bondi57 ↔ 99By similarity
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi80 ↔ 114By similarity

    Post-translational modificationi

    N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ0P543.

    Expressioni

    Gene expression databases

    BgeeiQ0P543.
    CleanExiMM_GIPR.
    GenevestigatoriQ0P543.

    Interactioni

    Subunit structurei

    May form homodimers and heterodimers with GLP1R.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000092384.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0P543.
    SMRiQ0P543. Positions 27-118, 133-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 134116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini156 – 22267CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 25512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini277 – 29721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini319 – 33719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini359 – 37012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini392 – 46069ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei135 – 15521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239460.
    GeneTreeiENSGT00740000115231.
    HOGENOMiHOG000008250.
    HOVERGENiHBG008318.
    InParanoidiQ0P543.
    KOiK04580.
    OMAiTRQMRCP.
    OrthoDBiEOG7TF78W.
    PhylomeDBiQ0P543.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR001749. GPCR_2_GIP_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR01129. GIPRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q0P543-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE    50
    PPSGLACNGS FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG 100
    SDGQWGSWRD HTQCENPEKN GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL 150
    ALLILSLFRR LHCTRNYIHM NLFTSFMLRA AAILTRDQLL PPLGPYTGDQ 200
    APTPWNQALA ACRTAQIMTQ YCVGANYTWL LVEGVYLHHL LVIVGRSEKG 250
    HFRCYLLLGW GAPALFVIPW VIVRYLRENT QCWERNEVKA IWWIIRTPIL 300
    ITILINFLIF IRILGILVSK LRTRQMRCPD YRLRLARSTL TLVPLLGVHE 350
    VVFAPVTEEQ VEGSLRFAKL AFEIFLSSFQ GFLVSVLYCF INKEVQSEIR 400
    QGWRHRRLRL SLQEQRPRPH QELAPRAVPL SSACREAAVG NALPSGMLHV 450
    PGDEVLESYC 460
    Length:460
    Mass (Da):52,992
    Last modified:October 2, 2007 - v2
    Checksum:i41ABC3F1E0A7DF98
    GO
    Isoform 2 (identifier: Q0P543-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         208-230: ALAACRTAQIMTQYCVGANYTWL → VLHRLLPGGTKTFPIYFRTFPHH
         231-460: Missing.

    Show »
    Length:230
    Mass (Da):26,617
    Checksum:iAA4800B55C77468E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221A → V in AAO85080. (PubMed:12679517)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei208 – 23023ALAAC…NYTWL → VLHRLLPGGTKTFPIYFRTF PHH in isoform 2. 1 PublicationVSP_028433Add
    BLAST
    Alternative sequencei231 – 460230Missing in isoform 2. 1 PublicationVSP_028434Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC145199 Genomic DNA. No translation available.
    BC120671 mRNA. Translation: AAI20672.1.
    BC120673 mRNA. Translation: AAI20674.1.
    AY255568 mRNA. Translation: AAO85080.1.
    CCDSiCCDS39795.1. [Q0P543-1]
    RefSeqiNP_001074284.1. NM_001080815.1. [Q0P543-1]
    UniGeneiMm.333633.

    Genome annotation databases

    EnsembliENSMUST00000094790; ENSMUSP00000092384; ENSMUSG00000030406. [Q0P543-1]
    GeneIDi381853.
    KEGGimmu:381853.
    UCSCiuc009fkw.1. mouse. [Q0P543-1]
    uc009fkx.1. mouse. [Q0P543-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC145199 Genomic DNA. No translation available.
    BC120671 mRNA. Translation: AAI20672.1 .
    BC120673 mRNA. Translation: AAI20674.1 .
    AY255568 mRNA. Translation: AAO85080.1 .
    CCDSi CCDS39795.1. [Q0P543-1 ]
    RefSeqi NP_001074284.1. NM_001080815.1. [Q0P543-1 ]
    UniGenei Mm.333633.

    3D structure databases

    ProteinModelPortali Q0P543.
    SMRi Q0P543. Positions 27-118, 133-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000092384.

    Chemistry

    GuidetoPHARMACOLOGYi 248.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q0P543.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094790 ; ENSMUSP00000092384 ; ENSMUSG00000030406 . [Q0P543-1 ]
    GeneIDi 381853.
    KEGGi mmu:381853.
    UCSCi uc009fkw.1. mouse. [Q0P543-1 ]
    uc009fkx.1. mouse. [Q0P543-2 ]

    Organism-specific databases

    CTDi 2696.
    MGIi MGI:1352753. Gipr.

    Phylogenomic databases

    eggNOGi NOG239460.
    GeneTreei ENSGT00740000115231.
    HOGENOMi HOG000008250.
    HOVERGENi HBG008318.
    InParanoidi Q0P543.
    KOi K04580.
    OMAi TRQMRCP.
    OrthoDBi EOG7TF78W.
    PhylomeDBi Q0P543.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 402687.
    PROi Q0P543.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q0P543.
    CleanExi MM_GIPR.
    Genevestigatori Q0P543.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR001749. GPCR_2_GIP_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR01129. GIPRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-178.

    Entry informationi

    Entry nameiGIPR_MOUSE
    AccessioniPrimary (citable) accession number: Q0P543
    Secondary accession number(s): Q80UB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3