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Protein

Fez family zinc finger protein 1

Gene

fezf1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription repressor. Involved in the development of the forebrain region (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri260 – 28223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42324C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 1
Gene namesi
Name:fezf1
Synonyms:fez
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-985988. fezf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Fez family zinc finger protein 1PRO_0000295118Add
BLAST

Proteomic databases

PaxDbiQ0P4W9.

Expressioni

Gene expression databases

BgeeiQ0P4W9.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049215.

Structurei

3D structure databases

ProteinModelPortaliQ0P4W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 4916Engrailed homology 1 repressorBy similarityAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri260 – 28223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42324C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ0P4W9.
OMAiCHNATAK.
OrthoDBiEOG7Z0JW5.
TreeFamiTF316780.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0P4W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSLQHKTT KIFPSQASRD SLSNRVTMIS GAKPLAFSIE RIMSRTPEPK
60 70 80 90 100
CLPVPSLLQG SVPKGDQKQA LHINSSSIPC MIPFVPVAYD HCPKIGISGA
110 120 130 140 150
ELRKSHLDSS PPFSCNDLLN CALTLKGDFP REALPLQQYK LVRPRVVNHS
160 170 180 190 200
SFHAMGAAFC YFNRGDSQCH PPASINIHPV ASYFLGSPLH QAPKSYLAER
210 220 230 240 250
NKLVLPSVEK FSSGVTFKDL SQAQFQHYMK EGAHSLSDKI TFKTSAKFSS
260 270 280 290 300
ASPSNKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KICGKGFRQA
310 320 330 340 350
STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG
360 370 380 390 400
KGFHQKGNYK NHKLTHSGEK QFKCNICNKA FHQIYNLTFH MHTHNDKKPF
410 420 430 440 450
TCPTCGKGFC RNFDLKKHVR KLHDSNTAAP HAIGGTGQEE LLLPNREPSP
460
TIQSPQLQKS GY
Length:462
Mass (Da):51,493
Last modified:September 19, 2006 - v1
Checksum:iBFC6AA92BDACA9BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121869 mRNA. Translation: AAI21870.1.
RefSeqiNP_001072463.1. NM_001078995.1.
UniGeneiStr.55601.

Genome annotation databases

EnsembliENSXETT00000049215; ENSXETP00000049215; ENSXETG00000022748.
GeneIDi779918.
KEGGixtr:779918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121869 mRNA. Translation: AAI21870.1.
RefSeqiNP_001072463.1. NM_001078995.1.
UniGeneiStr.55601.

3D structure databases

ProteinModelPortaliQ0P4W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049215.

Proteomic databases

PaxDbiQ0P4W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000049215; ENSXETP00000049215; ENSXETG00000022748.
GeneIDi779918.
KEGGixtr:779918.

Organism-specific databases

CTDi389549.
XenbaseiXB-GENE-985988. fezf1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ0P4W9.
OMAiCHNATAK.
OrthoDBiEOG7Z0JW5.
TreeFamiTF316780.

Gene expression databases

BgeeiQ0P4W9.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiFEZF1_XENTR
AccessioniPrimary (citable) accession number: Q0P4W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 19, 2006
Last modified: July 6, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.