Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

Gene

smarcal1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi461 – 4688ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC:3.6.4.-)
Alternative name(s):
HepA-related protein
Sucrose nonfermenting protein 2-like 1
Gene namesi
Name:smarcal1
Synonyms:harp
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-493391. smarcal1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 942942SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1PRO_0000361535Add
BLAST

Proteomic databases

PaxDbiQ0P4U8.

Expressioni

Gene expression databases

BgeeiENSXETG00000000465.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000000989.

Structurei

3D structure databases

ProteinModelPortaliQ0P4U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 29972HARP 1PROSITE-ProRule annotationAdd
BLAST
Domaini331 – 40272HARP 2PROSITE-ProRule annotationAdd
BLAST
Domaini448 – 603156Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini719 – 872154Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 2925Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi552 – 5554DESH box

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.PROSITE-ProRule annotation
Contains 2 HARP domains.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1000. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00630000089754.
HOGENOMiHOG000018734.
HOVERGENiHBG054110.
InParanoidiQ0P4U8.
KOiK14440.
OMAiEREDLCQ.
OrthoDBiEOG091G0A1B.
TreeFamiTF106474.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR010003. HARP_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07443. HARP. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51467. HARP. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0P4U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCLTEEQK RKIEENRQRA LARRAERLAA QQNSQTNRSL SAPLNAQIPS
60 70 80 90 100
GQQGVLPSAQ SINATGTSRA ANSKYAFQKS PSGGNTAPSV PGAAGNKVQA
110 120 130 140 150
VGNRSHDSKS LTDPAKDVKG NYTVPEAQSV PSGPSNAPNP RHLYPAGTTP
160 170 180 190 200
GQESAKHSNS YSRPEPLTAC DNDTTGPGPL RSTTTITKFY GAGPGSKPAV
210 220 230 240 250
PVSNKTVSEG RERGVTGSAA EAVPAKKASG ATRGRCVKHA ESRFRVEVGY
260 270 280 290 300
SAELIALFKT IPSKNYDPAT KMWNFGLEDY ASLMSEVQQL QSVELKALEG
310 320 330 340 350
MEGVQIAPPP ATGGGTNINA LLAMCNNWQR PSATLRGRCI LVSRSRFEME
360 370 380 390 400
IGYHAEIIGL FKQMNTRNYD TKTRKWSFML EDYQKLMESV RNIQQVEVEP
410 420 430 440 450
LPRPVLQAFA PQFGKTTIIR EEIPEVDLSQ VDSKLGSNLM PFQRDGVNFA
460 470 480 490 500
VSREGRLLLA DDMGLGKTIQ AICIAAYYRK EWPLLVVAPS SVRFTWAEAF
510 520 530 540 550
QRWLPSIRPE SVNVIVTGRD SQSASLINIV SFDLLGKMDK QIAATFQVII
560 570 580 590 600
IDESHFLKNV KTARCKAAMP LLKSAKRVML LSGTPAMSRP AELYTQIAAV
610 620 630 640 650
RPSFFPRFHD FGIRYCDAKQ MPWGWDYSGS SNLNELKLLL EESIMIRRLK
660 670 680 690 700
SEVLSQLPAK QRKMVVVAPE GITAKTKAAL AAAAKEMAKG FKSKVQEKEA
710 720 730 740 750
LLLFYNRTAE AKIRSVLEYI MDLLESGREK FLVFAHHKLV LDHICEELGK
760 770 780 790 800
KDVPYIRIDG NTSSADRQSL CHKFQMSEKS CVAVLSITAA NMGLTLSSAD
810 820 830 840 850
LVVFAELFWN PGVLIQAEDR VHRIGQTSSV NIHYLVAKGT ADDYLWPMIQ
860 870 880 890 900
EKIKVLGQAG LSEANFSETT ESTDYFYKDP KQKTIYDLFQ RSFSEEGAET
910 920 930 940
NADEALLLEA CEEADLGDAV CSPTDYSGNS CKRRKIDEYF AL
Length:942
Mass (Da):103,733
Last modified:September 19, 2006 - v1
Checksum:iE2C102F15FEFF062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121897 mRNA. Translation: AAI21898.1.
RefSeqiNP_001072923.1. NM_001079455.1.
UniGeneiStr.47258.

Genome annotation databases

EnsembliENSXETT00000000989; ENSXETP00000000989; ENSXETG00000000465.
GeneIDi780385.
KEGGixtr:780385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121897 mRNA. Translation: AAI21898.1.
RefSeqiNP_001072923.1. NM_001079455.1.
UniGeneiStr.47258.

3D structure databases

ProteinModelPortaliQ0P4U8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000000989.

Proteomic databases

PaxDbiQ0P4U8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000000989; ENSXETP00000000989; ENSXETG00000000465.
GeneIDi780385.
KEGGixtr:780385.

Organism-specific databases

CTDi50485.
XenbaseiXB-GENE-493391. smarcal1.

Phylogenomic databases

eggNOGiKOG1000. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00630000089754.
HOGENOMiHOG000018734.
HOVERGENiHBG054110.
InParanoidiQ0P4U8.
KOiK14440.
OMAiEREDLCQ.
OrthoDBiEOG091G0A1B.
TreeFamiTF106474.

Gene expression databases

BgeeiENSXETG00000000465.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR010003. HARP_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07443. HARP. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51467. HARP. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMAL1_XENTR
AccessioniPrimary (citable) accession number: Q0P4U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 19, 2006
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.