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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

Gene

smarcal1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi461 – 468ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC:3.6.4.-)
Alternative name(s):
HepA-related protein
Sucrose nonfermenting protein 2-like 1
Gene namesi
Name:smarcal1
Synonyms:harp
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-493391 smarcal1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003615351 – 942SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1Add BLAST942

Proteomic databases

PaxDbiQ0P4U8
PRIDEiQ0P4U8

Expressioni

Gene expression databases

BgeeiENSXETG00000000465

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000000989

Structurei

3D structure databases

ProteinModelPortaliQ0P4U8
SMRiQ0P4U8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 299HARP 1PROSITE-ProRule annotationAdd BLAST72
Domaini331 – 402HARP 2PROSITE-ProRule annotationAdd BLAST72
Domaini448 – 603Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST156
Domaini719 – 872Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 29Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi552 – 555DESH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1000 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00910000144109
HOGENOMiHOG000018734
HOVERGENiHBG054110
InParanoidiQ0P4U8
KOiK14440
OMAiANMGLTF
OrthoDBiEOG091G0A1B
TreeFamiTF106474

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR030101 HARP(SMARCAL1)
IPR010003 HARP_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR10799:SF731 PTHR10799:SF731, 2 hits
PfamiView protein in Pfam
PF07443 HARP, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51467 HARP, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q0P4U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCLTEEQK RKIEENRQRA LARRAERLAA QQNSQTNRSL SAPLNAQIPS
60 70 80 90 100
GQQGVLPSAQ SINATGTSRA ANSKYAFQKS PSGGNTAPSV PGAAGNKVQA
110 120 130 140 150
VGNRSHDSKS LTDPAKDVKG NYTVPEAQSV PSGPSNAPNP RHLYPAGTTP
160 170 180 190 200
GQESAKHSNS YSRPEPLTAC DNDTTGPGPL RSTTTITKFY GAGPGSKPAV
210 220 230 240 250
PVSNKTVSEG RERGVTGSAA EAVPAKKASG ATRGRCVKHA ESRFRVEVGY
260 270 280 290 300
SAELIALFKT IPSKNYDPAT KMWNFGLEDY ASLMSEVQQL QSVELKALEG
310 320 330 340 350
MEGVQIAPPP ATGGGTNINA LLAMCNNWQR PSATLRGRCI LVSRSRFEME
360 370 380 390 400
IGYHAEIIGL FKQMNTRNYD TKTRKWSFML EDYQKLMESV RNIQQVEVEP
410 420 430 440 450
LPRPVLQAFA PQFGKTTIIR EEIPEVDLSQ VDSKLGSNLM PFQRDGVNFA
460 470 480 490 500
VSREGRLLLA DDMGLGKTIQ AICIAAYYRK EWPLLVVAPS SVRFTWAEAF
510 520 530 540 550
QRWLPSIRPE SVNVIVTGRD SQSASLINIV SFDLLGKMDK QIAATFQVII
560 570 580 590 600
IDESHFLKNV KTARCKAAMP LLKSAKRVML LSGTPAMSRP AELYTQIAAV
610 620 630 640 650
RPSFFPRFHD FGIRYCDAKQ MPWGWDYSGS SNLNELKLLL EESIMIRRLK
660 670 680 690 700
SEVLSQLPAK QRKMVVVAPE GITAKTKAAL AAAAKEMAKG FKSKVQEKEA
710 720 730 740 750
LLLFYNRTAE AKIRSVLEYI MDLLESGREK FLVFAHHKLV LDHICEELGK
760 770 780 790 800
KDVPYIRIDG NTSSADRQSL CHKFQMSEKS CVAVLSITAA NMGLTLSSAD
810 820 830 840 850
LVVFAELFWN PGVLIQAEDR VHRIGQTSSV NIHYLVAKGT ADDYLWPMIQ
860 870 880 890 900
EKIKVLGQAG LSEANFSETT ESTDYFYKDP KQKTIYDLFQ RSFSEEGAET
910 920 930 940
NADEALLLEA CEEADLGDAV CSPTDYSGNS CKRRKIDEYF AL
Length:942
Mass (Da):103,733
Last modified:September 19, 2006 - v1
Checksum:iE2C102F15FEFF062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121897 mRNA Translation: AAI21898.1
RefSeqiNP_001072923.1, NM_001079455.1
UniGeneiStr.47258

Genome annotation databases

EnsembliENSXETT00000000989; ENSXETP00000000989; ENSXETG00000000465
GeneIDi780385
KEGGixtr:780385

Similar proteinsi

Entry informationi

Entry nameiSMAL1_XENTR
AccessioniPrimary (citable) accession number: Q0P4U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 19, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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