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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

Gene

smarcal1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi461 – 468ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC:3.6.4.-)
Alternative name(s):
HepA-related protein
Sucrose nonfermenting protein 2-like 1
Gene namesi
Name:smarcal1
Synonyms:harp
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-493391. smarcal1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003615351 – 942SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1Add BLAST942

Proteomic databases

PaxDbiQ0P4U8.

Expressioni

Gene expression databases

BgeeiENSXETG00000000465.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000000989.

Structurei

3D structure databases

ProteinModelPortaliQ0P4U8.
SMRiQ0P4U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 299HARP 1PROSITE-ProRule annotationAdd BLAST72
Domaini331 – 402HARP 2PROSITE-ProRule annotationAdd BLAST72
Domaini448 – 603Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST156
Domaini719 – 872Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 29Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi552 – 555DESH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1000. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00860000133750.
HOGENOMiHOG000018734.
HOVERGENiHBG054110.
InParanoidiQ0P4U8.
KOiK14440.
OMAiANMGLTF.
OrthoDBiEOG091G0A1B.
TreeFamiTF106474.

Family and domain databases

InterProiView protein in InterPro
IPR030101. HARP(SMARCAL1).
IPR010003. HARP_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
PANTHERiPTHR10799:SF793. PTHR10799:SF793. 1 hit.
PfamiView protein in Pfam
PF07443. HARP. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS51467. HARP. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0P4U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCLTEEQK RKIEENRQRA LARRAERLAA QQNSQTNRSL SAPLNAQIPS
60 70 80 90 100
GQQGVLPSAQ SINATGTSRA ANSKYAFQKS PSGGNTAPSV PGAAGNKVQA
110 120 130 140 150
VGNRSHDSKS LTDPAKDVKG NYTVPEAQSV PSGPSNAPNP RHLYPAGTTP
160 170 180 190 200
GQESAKHSNS YSRPEPLTAC DNDTTGPGPL RSTTTITKFY GAGPGSKPAV
210 220 230 240 250
PVSNKTVSEG RERGVTGSAA EAVPAKKASG ATRGRCVKHA ESRFRVEVGY
260 270 280 290 300
SAELIALFKT IPSKNYDPAT KMWNFGLEDY ASLMSEVQQL QSVELKALEG
310 320 330 340 350
MEGVQIAPPP ATGGGTNINA LLAMCNNWQR PSATLRGRCI LVSRSRFEME
360 370 380 390 400
IGYHAEIIGL FKQMNTRNYD TKTRKWSFML EDYQKLMESV RNIQQVEVEP
410 420 430 440 450
LPRPVLQAFA PQFGKTTIIR EEIPEVDLSQ VDSKLGSNLM PFQRDGVNFA
460 470 480 490 500
VSREGRLLLA DDMGLGKTIQ AICIAAYYRK EWPLLVVAPS SVRFTWAEAF
510 520 530 540 550
QRWLPSIRPE SVNVIVTGRD SQSASLINIV SFDLLGKMDK QIAATFQVII
560 570 580 590 600
IDESHFLKNV KTARCKAAMP LLKSAKRVML LSGTPAMSRP AELYTQIAAV
610 620 630 640 650
RPSFFPRFHD FGIRYCDAKQ MPWGWDYSGS SNLNELKLLL EESIMIRRLK
660 670 680 690 700
SEVLSQLPAK QRKMVVVAPE GITAKTKAAL AAAAKEMAKG FKSKVQEKEA
710 720 730 740 750
LLLFYNRTAE AKIRSVLEYI MDLLESGREK FLVFAHHKLV LDHICEELGK
760 770 780 790 800
KDVPYIRIDG NTSSADRQSL CHKFQMSEKS CVAVLSITAA NMGLTLSSAD
810 820 830 840 850
LVVFAELFWN PGVLIQAEDR VHRIGQTSSV NIHYLVAKGT ADDYLWPMIQ
860 870 880 890 900
EKIKVLGQAG LSEANFSETT ESTDYFYKDP KQKTIYDLFQ RSFSEEGAET
910 920 930 940
NADEALLLEA CEEADLGDAV CSPTDYSGNS CKRRKIDEYF AL
Length:942
Mass (Da):103,733
Last modified:September 19, 2006 - v1
Checksum:iE2C102F15FEFF062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121897 mRNA. Translation: AAI21898.1.
RefSeqiNP_001072923.1. NM_001079455.1.
UniGeneiStr.47258.

Genome annotation databases

EnsembliENSXETT00000000989; ENSXETP00000000989; ENSXETG00000000465.
GeneIDi780385.
KEGGixtr:780385.

Similar proteinsi

Entry informationi

Entry nameiSMAL1_XENTR
AccessioniPrimary (citable) accession number: Q0P4U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 19, 2006
Last modified: September 27, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families