ID   S5A3_XENTR              Reviewed;         308 AA.
AC   Q0P4J9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=3-oxo-5-alpha-steroid 4-dehydrogenase 3;
DE            EC=1.3.99.5;
DE   AltName: Full=Steroid 5-alpha-reductase 3;
DE   AltName: Full=SR type 3;
GN   Name=srd5a3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts testosterone (T) into 5-alpha-
CC       dihydrotestosterone (DHT) (By similarity).
CC   -!- CATALYTIC ACTIVITY: A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-
CC       Delta(4)-steroid + reduced acceptor.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane
CC       protein (By similarity). Endoplasmic reticulum membrane; Multi-
CC       pass membrane protein (Potential).
CC   -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
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DR   EMBL; BC122039; AAI22040.1; -; mRNA.
DR   RefSeq; NP_001072539.1; -.
DR   UniGene; Str.24988; -.
DR   GeneID; 779994; -.
DR   KEGG; xtr:779994; -.
DR   Xenbase; XB-FEAT-985510; srd5a3.
DR   HOVERGEN; Q0P4J9; -.
DR   BRENDA; 1.3.99.5; 279072.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003865; F:3-oxo-5-alpha-steroid 4-dehydrogenase activity; IEA:EC.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   Pfam; PF02544; Steroid_dh; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Microsome; Oxidoreductase;
KW   Transmembrane.
FT   CHAIN         1    308       3-oxo-5-alpha-steroid 4-dehydrogenase 3.
FT                                /FTId=PRO_0000317706.
FT   TRANSMEM      3     23       Potential.
FT   TRANSMEM     66     86       Potential.
FT   TRANSMEM    121    141       Potential.
FT   TRANSMEM    149    169       Potential.
FT   TRANSMEM    185    205       Potential.
FT   TRANSMEM    256    276       Potential.
SQ   SEQUENCE   308 AA;  35876 MW;  FFE931DCDB0D558A CRC64;
     MTLLALVWLL LDATFLITLL WHLLQGCKSG HSLLCSVFQD LIRYGKTKTG LQRPAWLQWF
     DIPKRCFWHF YCVSLIWNGC LLWILLRLLL QSVPVPEWLQ LVLHFLHAGS EPQILDRELS
     VILALALLWL HSLRRLLECL FVSVFSNGVI HLVQYCFGLG YYFLIGITVL TYCPLDRRTV
     STDNLLTQCH WYHILGLALY IWASLHQYRC HCILAGLRKS ASGNVINLNH SVPCGDWFER
     VSCPHYFAEL LIYVSIAVVF GLLNTIWWLV VLYVLLNQAL AALLCHEFYH EKFDTYPIHR
     KAFIPFIF
//