Reviewed, UniProtKB/Swiss-Prot Q0P4J9 (S5A3_XENTR)

Names and origin

Protein names

Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 3
    EC=1.3.99.5
Alternative name(s):
    Steroid 5-alpha-reductase 3
    SR type 3

Gene names

Name:

srd5a3

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) By similarity.
Catalytic activity	A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.
Subcellular location	Microsome membrane; Multi-pass membrane proteinBy similarity. Endoplasmic reticulum membrane; Multi-pass membrane proteinPotential.
Sequence similarities	Belongs to the steroid 5-alpha reductase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	lipid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxo-5-alpha-steroid 4-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	3-oxo-5-alpha-steroid 4-dehydrogenase 3		PRO_0000317706
Regions
	Transmembrane	3 – 23	21	Potential
	Transmembrane	66 – 86	21	Potential
	Transmembrane	121 – 141	21	Potential
	Transmembrane	149 – 169	21	Potential
	Transmembrane	185 – 205	21	Potential
	Transmembrane	256 – 276	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0P4J9-1 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: FFE931DCDB0D558A	FASTA	308	35,876
	10 20 30 40 50 60 MTLLALVWLL LDATFLITLL WHLLQGCKSG HSLLCSVFQD LIRYGKTKTG LQRPAWLQWF 70 80 90 100 110 120 DIPKRCFWHF YCVSLIWNGC LLWILLRLLL QSVPVPEWLQ LVLHFLHAGS EPQILDRELS 130 140 150 160 170 180 VILALALLWL HSLRRLLECL FVSVFSNGVI HLVQYCFGLG YYFLIGITVL TYCPLDRRTV 190 200 210 220 230 240 STDNLLTQCH WYHILGLALY IWASLHQYRC HCILAGLRKS ASGNVINLNH SVPCGDWFER 250 260 270 280 290 300 VSCPHYFAEL LIYVSIAVVF GLLNTIWWLV VLYVLLNQAL AALLCHEFYH EKFDTYPIHR KAFIPFIF

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: N6. Tissue: Ovary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC122039 mRNA. Translation: AAI22040.1.
RefSeq	NP_001072539.1.
UniGene	Str.24988
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	779994.
KEGG	xtr:779994.
Organism-specific databases
Xenbase	XB-FEAT-985510. srd5a3.
Phylogenomic databases
HOVERGEN	Q0P4J9.
Family and domain databases
InterPro	IPR001104. 3-oxo-5_a-steroid_4-DHase_C. [Graphical view]
Pfam	PF02544. Steroid_dh. 1 hit. [Graphical view]
PROSITE	PS50244. S5A_REDUCTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

S5A3_XENTR

Accession

Primary (citable) accession number: Q0P4J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 19, 2006
Last modified:	November 25, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project