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Reviewed, UniProtKB/Swiss-Prot Q0P4J9 (S5A3_XENTR)

Last modified November 25, 2008. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 3
    EC=1.3.99.5
Alternative name(s):
    Steroid 5-alpha-reductase 3
    SR type 3
Gene names
Name: srd5a3
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraMesobatrachiaPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) By similarity.

Catalytic activity

A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.

Subcellular location

Microsome membrane; Multi-pass membrane proteinBy similarity. Endoplasmic reticulum membrane; Multi-pass membrane proteinPotential.

Sequence similarities

Belongs to the steroid 5-alpha reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3083083-oxo-5-alpha-steroid 4-dehydrogenase 3
PRO_0000317706

Regions

Transmembrane3 – 2321 Potential
Transmembrane66 – 8621 Potential
Transmembrane121 – 14121 Potential
Transmembrane149 – 16921 Potential
Transmembrane185 – 20521 Potential
Transmembrane256 – 27621 Potential

Sequences

Sequence LengthMass (Da)Tools
Q0P4J9-1 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: FFE931DCDB0D558A

FASTA30835,876
        10         20         30         40         50         60 
MTLLALVWLL LDATFLITLL WHLLQGCKSG HSLLCSVFQD LIRYGKTKTG LQRPAWLQWF 

        70         80         90        100        110        120 
DIPKRCFWHF YCVSLIWNGC LLWILLRLLL QSVPVPEWLQ LVLHFLHAGS EPQILDRELS 

       130        140        150        160        170        180 
VILALALLWL HSLRRLLECL FVSVFSNGVI HLVQYCFGLG YYFLIGITVL TYCPLDRRTV 

       190        200        210        220        230        240 
STDNLLTQCH WYHILGLALY IWASLHQYRC HCILAGLRKS ASGNVINLNH SVPCGDWFER 

       250        260        270        280        290        300 
VSCPHYFAEL LIYVSIAVVF GLLNTIWWLV VLYVLLNQAL AALLCHEFYH EKFDTYPIHR 


KAFIPFIF 

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: N6.
Tissue: Ovary.

Cross-references

Sequence databases

BC122039 mRNA. Translation: AAI22040.1.
RefSeqNP_001072539.1.
UniGeneStr.24988

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID779994.
KEGGxtr:779994.

Organism-specific databases

XenbaseXB-FEAT-985510. srd5a3.

Phylogenomic databases

HOVERGENQ0P4J9.

Family and domain databases

InterProIPR001104. 3-oxo-5_a-steroid_4-DHase_C.
[Graphical view]
PfamPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameS5A3_XENTR
AccessionPrimary (citable) accession number: Q0P4J9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 19, 2006
Last modified: November 25, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents