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Q0P4G8 (MTBP_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mdm2-binding protein
Gene names
Name:mtbp
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length867 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation By similarity.

Sequence similarities

Belongs to the MTBP family.

Sequence caution

The sequence AAI22087.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCell cycle
Growth arrest
Ubl conjugation pathway
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcell cycle arrest

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 867867Mdm2-binding protein
PRO_0000323748

Sequences

Sequence LengthMass (Da)Tools
Q0P4G8 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: C0B9694A05530FD5

FASTA86797,059
        10         20         30         40         50         60 
MERFVLCIHW ERRAESGAEQ HRVPQGLAYA QDIYTQLKEY STKYTSTFPA CSLTGNPGTR 

        70         80         90        100        110        120 
KWFFALQSLY GSFQFCSSDW DDLCPAVTTE DNEEPVQTAL DECLEALQFP DGEDDNSRDS 

       130        140        150        160        170        180 
ISQTNLFEEA AELLHQLSDK LPAPGRALVD VLLFTPEAPK LKDCLSAIGA IKHLKEWHSA 

       190        200        210        220        230        240 
KITIVSKDCK GWQKIAKFLS ANVVESACPK ELIDSHELWR GNIEISERKF TSEVEFPEFC 

       250        260        270        280        290        300 
LRSVSDDKFP YFEHNGDDKN KAVLLPEVFH YYGTSLEYVQ MVALSEIPSY FVSDSVFELS 

       310        320        330        340        350        360 
ITRNALQGKS KLMLDQLCSL TDKVGAIFML SCNVCSLPNP PALQRSSKKW REYMSRKPKD 

       370        380        390        400        410        420 
IKVPGVELKG EYCSYYFLIQ GKGSGFCKAT LLHSASQISG AASLVLLHQR LNNYQPGNMA 

       430        440        450        460        470        480 
EGTSEILDSV PHFRGEQIAV RERILARAQA LAVNEYLKRH EALPHPSVSH VNNLRTLLAV 

       490        500        510        520        530        540 
TRERVIGDCE SRLDGVSYKN LQNITVSTPT VSESEAMISN PADWPERNVL QNLENFEKVK 

       550        560        570        580        590        600 
QRLRASILSS SAEQLLGRKD GLKEGMTLLD AKELLKYFTP QGIAVGELQP LQVQRGDNAF 

       610        620        630        640        650        660 
LLTPKLTPKK LKGLPFEKAA ECHYHGLEYC LDNRKALDRD VAFSELQSRL IRYETQTTCT 

       670        680        690        700        710        720 
RECCPVPFAL SPLPSPAVLS EPGSVPDGES IQTELRGEPL LLKRRSRDLD GLYASKRLAK 

       730        740        750        760        770        780 
SGSSDSLVSL ASEGSGHQPP TRATRLRPER AASSTSAVQP PSARVQMAPS VPAQSKQSTH 

       790        800        810        820        830        840 
PDLEQKESRS QKHNRMLKEV VSKTLQKYGI GVEHPCYAAC NQRLFDISKF FLKDLKTSRG 

       850        860 
LLDEMKKAAS NNAKQVIQWE LDKLKKK

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: N6.
Tissue: Oviduct and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC122086 mRNA. Translation: AAI22087.1. Different initiation.
BC155673 mRNA. Translation: AAI55674.1.
RefSeqNP_001107690.1. NM_001114218.1.
UniGeneStr.16675.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID779505.
KEGGxtr:779505.

Organism-specific databases

CTD27085.
XenbaseXB-GENE-990920. mtbp.

Phylogenomic databases

eggNOGveNOG12500.
GeneTreeENSGT00390000003305.
HOVERGENHBG108152.

Gene expression databases

BgeeQ0P4G8.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameMTBP_XENTR
AccessionPrimary (citable) accession number: Q0P4G8
Secondary accession number(s): A9JRI5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 21, 2011
This is version 24 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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