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Protein

Poly(A) polymerase catalytic subunit

Gene

VARV_JAP46_yam_045

Organism
Variola virus (isolate Human/Japan/Yamada MS-2(A)/1946) (VARV) (Smallpox virus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.UniRule annotation

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202UniRule annotation1
Active sitei204UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processmRNA processingUniRule annotation, TranscriptionUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunitUniRule annotation (EC:2.7.7.19UniRule annotation)
Alternative name(s):
Poly(A) polymerase large subunitUniRule annotation
Gene namesi
ORF Names:VARV_JAP46_yam_045Imported
OrganismiVariola virus (isolate Human/Japan/Yamada MS-2(A)/1946) (VARV) (Smallpox virus)Imported
Taxonomic identifieri587202 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000006909 Componenti: Genome

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 117Pox_polyA_pol_NInterPro annotationAdd BLAST103
Domaini132 – 279Pox_polyA_polInterPro annotationAdd BLAST148
Domaini282 – 478Pox_polyA_pol_CInterPro annotationAdd BLAST197

Sequence similaritiesi

Belongs to the poxviridae poly(A) polymerase catalytic subunit family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR037265. PolyA_pol_cat_sf.
IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxviridae_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
PfamiView protein in Pfam
PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
PIRSFiPIRSF015693. VAC-48L_nuct. 2 hits.
SUPFAMiSSF160957. SSF160957. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0NG97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRNPDHNTL PNITLKIIET YLGRLPSVNE YHMLKLQTRN IQKITVFNKD
60 70 80 90 100
IFVSLVKKNK KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL
110 120 130 140 150
QSVLVTTYTD ILGVLTIKAP NVISSKISYN VTSMEELARD MLNSMNVAVI
160 170 180 190 200
DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN KSCICYGSYS LYLINPNIRY
210 220 230 240 250
GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY MVIKDENDNH
260 270 280 290 300
IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK
310 320 330 340 350
DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRVVTVTTKD
360 370 380 390 400
YFSFKKCLVY LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF
410 420 430 440 450
SNTILLSDKG KVHEISARGL CAHILLYQML TSGAYKQCLS DLLNSMMNRD
460 470
KIPIYSHTER DKKHGRHGFI NIEKDIIVF
Length:479
Mass (Da):55,553
Last modified:March 24, 2009 - v1
Checksum:i63EC3937D25A9149
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ441429 Genomic DNA. Translation: ABF25416.1.

Similar proteinsi

Entry informationi

Entry nameiQ0NG97_VAR46
AccessioniPrimary (citable) accession number: Q0NG97
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: December 20, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported