Unreviewed, UniProtKB/TrEMBL Q0MWT5 (Q0MWT5_HUMAN)

Names and origin

Protein names

Submitted name:
    Estrogen receptor beta isoform 5 EMBL ABH09190.1

Gene names

Name:

ESR2 EMBL ABH09190.1

Organism

Homo sapiens (Human) EMBL ABH09190.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377V1 Contains 1 nuclear receptor DNA-binding domain. Spearmint SPM001723

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334V0 Spearmint SPM001723
Cellular component	Nucleus RuleBase RU004334V0 Spearmint SPM001723
Domain	Zinc-finger RuleBase RU004334V0 Spearmint SPM001723
Ligand	DNA-binding RuleBase RU004334V0 Spearmint SPM001723 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334V0 Spearmint SPM001723
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0MWT5-1 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: 673B0DB5FAF03C26	FASTA	472	52,959
	10 20 30 40 50 60 MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 70 80 90 100 110 120 NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 130 140 150 160 170 180 RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 190 200 210 220 230 240 NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH 250 260 270 280 290 300 CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 310 320 330 340 350 360 LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 370 380 390 400 410 420 VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 430 440 450 460 470 DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARY AP

References

[1]	"Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling." Leung Y.K., Mak P., Hassan S., Ho S.M. Proc. Natl. Acad. Sci. U.S.A. 103:13162-13167(2006) [PubMed: 16938840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Prostate EMBL ABH09190.1.
[2]	Leung Y.-K., Ho S.-M. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Prostate EMBL ABH09190.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ838583 mRNA. Translation: ABH09190.1.
UniGene	Hs.525392 Hs.660607
3D structure databases
SMR	Q0MWT5. Positions 144-216, 263-468.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000140009. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:3468. ESR2.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q0MWT5.
Gene expression databases
ArrayExpress	Q0MWT5.
Family and domain databases
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR000324. VitD_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00398. STRDHORMONER. PR00047. STROIDFINGER. PR00350. VITAMINDR.
ProDom	PD000035. Znf_C4steroid. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]

Entry information

Entry name

Q0MWT5_HUMAN

Accession

Primary (citable) accession number: Q0MWT5

Entry history

Integrated into UniProtKB/TrEMBL:	September 19, 2006
Last sequence update:	September 19, 2006
Last modified:	July 22, 2008
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)