ID   QOR_PIG                 Reviewed;         329 AA.
AC   Q0MVN8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Quinone oxidoreductase;
DE            EC=1.6.5.5;
DE   AltName: Full=NADPH:quinone reductase;
DE   AltName: Full=Zeta-crystallin;
GN   Name=CRYZ;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RA   Ibrahim H.M., Curthoys N.P.;
RT   "Sus scrofa renal zeta-crystallin (NADPH quinone reductase) cDNA.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Does not have alcohol dehydrogenase activity. Binds NADP
CC       and acts through a one-electron transfer process. Orthoquinones
CC       are the best substrates. May act in the detoxification of
CC       xenobiotics (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADPH + 2 quinone = NADP(+) + 2 semiquinone.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily.
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DR   EMBL; DQ841573; ABH10011.1; -; mRNA.
DR   UniGene; Ssc.3029; -.
DR   SMR; Q0MVN8; 6-329.
DR   HOVERGEN; Q0MVN8; -.
DR   BRENDA; 1.6.5.5; 249.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003960; F:NADPH:quinone reductase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; NADP; Oxidoreductase.
FT   CHAIN         1    329       Quinone oxidoreductase.
FT                                /FTId=PRO_0000251735.
SQ   SEQUENCE   329 AA;  34997 MW;  2D62ECE3555D0AC3 CRC64;
     MATGQKLMSA IRVFKFGGPE VMKLQSDVAI PIPKDNQVLI KVHACGVNPV DTYIRSGTHN
     MKPLLPYTPG LDVAGIVEAV GEHVSSFKKG DRVFTVSTLS GGYAEYALAA DDTVYMLPEK
     LDFKQGAAIG IPYFTACLAL LHSACVKAGE IVLIHGASGG VGIAACQIAR AYGLKVLGTA
     GTEEGQNIVL QNGAHEVFNH REVNYIDKIK KSVGEKGIDV IIEMLANVNL SNDLNLLSHG
     GRVIIVGSRG PIEINPRDTM TKGSSIKGVA LYSSTKEEFQ QLAAALQAGM EVGWLRPVIG
     PVYPLEKAAQ AHEDIIHSRG ATGKMILLL
//