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Reviewed, UniProtKB/Swiss-Prot Q0MVN8 (QOR_PIG)

Last modified November 25, 2008. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Quinone oxidoreductase
    EC=1.6.5.5
Alternative name(s):
    NADPH:quinone reductase
    Zeta-crystallin
Gene names
Name: CRYZ
OrganismSus scrofa (Pig)
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones are the best substrates. May act in the detoxification of xenobiotics By similarity.

Catalytic activity

NADPH + 2 quinone = NADP(+) + 2 semiquinone.

Subunit structure

Homotetramer By similarity.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords

   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADPH:quinone reductase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329Quinone oxidoreductase
PRO_0000251735

Sequences

Sequence LengthMass (Da)Tools
Q0MVN8-1 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: 2D62ECE3555D0AC3

FASTA32934,997
        10         20         30         40         50         60 
MATGQKLMSA IRVFKFGGPE VMKLQSDVAI PIPKDNQVLI KVHACGVNPV DTYIRSGTHN 

        70         80         90        100        110        120 
MKPLLPYTPG LDVAGIVEAV GEHVSSFKKG DRVFTVSTLS GGYAEYALAA DDTVYMLPEK 

       130        140        150        160        170        180 
LDFKQGAAIG IPYFTACLAL LHSACVKAGE IVLIHGASGG VGIAACQIAR AYGLKVLGTA 

       190        200        210        220        230        240 
GTEEGQNIVL QNGAHEVFNH REVNYIDKIK KSVGEKGIDV IIEMLANVNL SNDLNLLSHG 

       250        260        270        280        290        300 
GRVIIVGSRG PIEINPRDTM TKGSSIKGVA LYSSTKEEFQ QLAAALQAGM EVGWLRPVIG 

       310        320 
PVYPLEKAAQ AHEDIIHSRG ATGKMILLL 

« Hide

References

[1]"Sus scrofa renal zeta-crystallin (NADPH quinone reductase) cDNA."
Ibrahim H.M., Curthoys N.P.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

DQ841573 mRNA. Translation: ABH10011.1.

3D structure databases

SMRQ0MVN8. Positions 6-329.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ0MVN8.

Family and domain databases

InterProIPR013154. AlcDHase_GroES-like.
IPR002085. AlcDHase_SF_Zn.
IPR013149. AlcDHase_Zn-bd.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQOR_PIG
AccessionPrimary (citable) accession number: Q0MVN8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 19, 2006
Last modified: November 25, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents