Reviewed, UniProtKB/Swiss-Prot Q0MVN8 (QOR_PIG)

Names and origin

Protein names

Recommended name:
    Quinone oxidoreductase
    EC=1.6.5.5
Alternative name(s):
    NADPH:quinone reductase
    Zeta-crystallin

Gene names

Name:

CRYZ

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones are the best substrates. May act in the detoxification of xenobiotics By similarity.
Catalytic activity	NADPH + 2 quinone = NADP(+) + 2 semiquinone.
Subunit structure	Homotetramer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADPH:quinone reductase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Quinone oxidoreductase		PRO_0000251735

Sequences

	Sequence		Length	Mass (Da)
	Q0MVN8-1 [UniParc]. Last modified September 19, 2006. Version 1. Checksum: 2D62ECE3555D0AC3	FASTA	329	34,997
	10 20 30 40 50 60 MATGQKLMSA IRVFKFGGPE VMKLQSDVAI PIPKDNQVLI KVHACGVNPV DTYIRSGTHN 70 80 90 100 110 120 MKPLLPYTPG LDVAGIVEAV GEHVSSFKKG DRVFTVSTLS GGYAEYALAA DDTVYMLPEK 130 140 150 160 170 180 LDFKQGAAIG IPYFTACLAL LHSACVKAGE IVLIHGASGG VGIAACQIAR AYGLKVLGTA 190 200 210 220 230 240 GTEEGQNIVL QNGAHEVFNH REVNYIDKIK KSVGEKGIDV IIEMLANVNL SNDLNLLSHG 250 260 270 280 290 300 GRVIIVGSRG PIEINPRDTM TKGSSIKGVA LYSSTKEEFQ QLAAALQAGM EVGWLRPVIG 310 320 PVYPLEKAAQ AHEDIIHSRG ATGKMILLL

References

[1]	"Sus scrofa renal zeta-crystallin (NADPH quinone reductase) cDNA." Ibrahim H.M., Curthoys N.P. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ841573 mRNA. Translation: ABH10011.1.
3D structure databases
SMR	Q0MVN8. Positions 6-329.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q0MVN8.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002364. Quin_OxRdtase/zeta-crystal_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS01162. QOR_ZETA_CRYSTAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QOR_PIG

Accession

Primary (citable) accession number: Q0MVN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	September 19, 2006
Last modified:	November 25, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)