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Q0MQI9

- NDUV2_PANTR

UniProt

Q0MQI9 - NDUV2_PANTR

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Protein
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Gene
NDUFV2
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 2Fe-2S cluster Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi135 – 1351Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi140 – 1401Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi176 – 1761Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi180 – 1801Iron-sulfur (2Fe-2S) Reviewed prediction

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. NADH dehydrogenase (ubiquinone) activity Source: RefGenome
  3. electron carrier activity Source: RefGenome
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH-ubiquinone oxidoreductase 24 kDa subunit
Gene namesi
Name:NDUFV2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 18

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex I Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232Mitochondrion
Add
BLAST
Chaini33 – 249217NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
PRO_0000251880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-acetyllysine By similarity
Modified residuei193 – 1931Phosphotyrosine; by SRC By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ0MQI9.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000055766.

Structurei

3D structure databases

ProteinModelPortaliQ0MQI9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1905.
GeneTreeiENSGT00390000017580.
HOGENOMiHOG000257748.
HOVERGENiHBG029601.
KOiK03943.
OMAiVHRDTPY.
OrthoDBiEOG73JKW9.
TreeFamiTF300004.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10371. PTHR10371. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
PROSITEiPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0MQI9-1 [UniParc]FASTAAdd to Basket

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MFFSAALRAR AAGLTAHWGR HVRNLHKTAK QNGAGGALFV HRDTPENNPD    50
TPFDFTPENY KRIEAIVKNY PEGHKAAAVL PVLDLAQRQN GWLPISAMNK 100
VAEVLQVPPM RVYEVATFYT MYNRKPVGKY HIQVCTTTPC MLRNSDSILE 150
AIQKKLGIKV GETTPDKLFT LIEVECLGAC VNAPMVQIND NYYEDLTAKD 200
IEEIIDELKA GKIPKPGPRS GRFSCEPAGG LTSLTEPPKG PGFGVQAGL 249
Length:249
Mass (Da):27,360
Last modified:September 19, 2006 - v1
Checksum:iA94C5139329B084F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ885645 mRNA. Translation: ABH12154.1.
RefSeqiNP_001065254.1. NM_001071786.1.
UniGeneiPtr.400.

Genome annotation databases

EnsembliENSPTRT00000018107; ENSPTRP00000016775; ENSPTRG00000009856.
GeneIDi455295.
KEGGiptr:455295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ885645 mRNA. Translation: ABH12154.1 .
RefSeqi NP_001065254.1. NM_001071786.1.
UniGenei Ptr.400.

3D structure databases

ProteinModelPortali Q0MQI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000055766.

Proteomic databases

PRIDEi Q0MQI9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000018107 ; ENSPTRP00000016775 ; ENSPTRG00000009856 .
GeneIDi 455295.
KEGGi ptr:455295.

Organism-specific databases

CTDi 4729.

Phylogenomic databases

eggNOGi COG1905.
GeneTreei ENSGT00390000017580.
HOGENOMi HOG000257748.
HOVERGENi HBG029601.
KOi K03943.
OMAi VHRDTPY.
OrthoDBi EOG73JKW9.
TreeFami TF300004.

Miscellaneous databases

NextBioi 20836712.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR10371. PTHR10371. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
PROSITEi PS01099. COMPLEX1_24K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Adaptive selection of mitochondrial complex I subunits during primate radiation."
    Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.
    Gene 378:11-18(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNDUV2_PANTR
AccessioniPrimary (citable) accession number: Q0MQI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 19, 2006
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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