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Q0MQI7 (NDUV2_PONPY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
NADH-ubiquinone oxidoreductase 24 kDa subunit
Gene names
Name:NDUFV2
OrganismPongo pygmaeus (Bornean orangutan)
Taxonomic identifier9600 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 2Fe-2S cluster Potential.

Subunit structure

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.

Subcellular location

Mitochondrion inner membrane By similarity.

Sequence similarities

Belongs to the complex I 24 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3232Mitochondrion
Chain33 – 249217NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
PRO_0000251881

Sites

Metal binding1351Iron-sulfur (2Fe-2S) Potential
Metal binding1401Iron-sulfur (2Fe-2S) Potential
Metal binding1761Iron-sulfur (2Fe-2S) Potential
Metal binding1801Iron-sulfur (2Fe-2S) Potential

Amino acid modifications

Modified residue611N6-acetyllysine By similarity
Modified residue1931Phosphotyrosine; by SRC By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0MQI7 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: 500355C8F6BE2C78

FASTA24927,354
        10         20         30         40         50         60 
MFFSAALRAR AAGLTAQWGR HVRNLHKTAM QNGAGGALFV HRDTPENNPD TPFDFTPENY 

        70         80         90        100        110        120 
KRIEAIVKNY PEGHKAAAVL PVLDLAQRQN GWLPISAMNK VAEVLQVPPM RVYEVATFYT 

       130        140        150        160        170        180 
MYNRKPVGKY HIQVCTTTPC MLRNSDSILE AIQKKLGIKV GETTPDKLFT LIEVECLGAC 

       190        200        210        220        230        240 
VNAPMVQIND NYYEDLTAKD IEEIIDELKA GKIPKPGPRS GRFSCEPAGG LTSLTEPPKG 


PGFGVQAGL 

« Hide

References

[1]"Adaptive selection of mitochondrial complex I subunits during primate radiation."
Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.
Gene 378:11-18(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ885647 mRNA. Translation: ABH12156.1.

3D structure databases

ProteinModelPortalQ0MQI7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9600.ENSPPYP00000010113.

Proteomic databases

PRIDEQ0MQI7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1905.
HOGENOMHOG000257748.
HOVERGENHBG029601.
InParanoidQ0MQI7.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR10371. PTHR10371. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR01958. nuoE_fam. 1 hit.
PROSITEPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUV2_PONPY
AccessionPrimary (citable) accession number: Q0MQI7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 19, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families