Reviewed,
UniProtKB/Swiss-Prot Q0MQI0 (NDUS7_PANTR)
Last modified
November 25, 2008.
Version 15.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial EC=1.6.5.3 EC=1.6.99.3 Alternative name(s): NADH-ubiquinone oxidoreductase 20 kDa subunit Complex I-20kD Short name=CI-20kD | ||
| Gene names |
| ||
| Organism | Pan troglodytes (Chimpanzee) | ||
| Taxonomic identifier | 9598 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Protein attributes
| Sequence length | 213 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. |
| Catalytic activity | NADH + ubiquinone = NAD(+) + ubiquinol. NADH + acceptor = NAD(+) + reduced acceptor. |
| Cofactor | Binds 1 4Fe-4S cluster Potential. |
| Subunit structure | Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity. |
| Subcellular location | MitochondrionBy similarity. |
| Sequence similarities | Belongs to the complex I 20 kDa subunit family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 38 | 38 | Mitochondrion By similarity | ||||||
| Chain | 39 – 213 | 175 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | PRO_0000251873 | |||||
Sites | |||||||||
| Metal binding | 88 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 89 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 153 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 183 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
Sequences
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References
| [1] | "Adaptive selection of mitochondrial complex I subunits during primate radiation." Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C. Gene 378:11-18(2006) [PubMed: 16828987] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| DQ885654 mRNA. Translation: ABH12163.1. | |
| RefSeq | NP_001103713.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 100126358. |
| KEGG | ptr:100126358. |
Phylogenomic databases | |
| HOVERGEN | Q0MQI0. |
Family and domain databases | |
| InterPro | IPR006138. NADH_DHase_20kDa_su. IPR014406. NiFe_hyd_3_ssu/Q_oxred_NuoB. IPR006137. OxRdtase_q6. [Graphical view] |
| PANTHER | PTHR11995:SF2. NADH_DH_20kDa. 1 hit. PTHR11995. NiFe_hyd_3_ssu/Q_oxred_NuoB. 1 hit. |
| Pfam | PF01058. Oxidored_q6. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01957. nuoB_fam. 1 hit. |
| PROSITE | PS01150. COMPLEX1_20K. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NDUS7_PANTR | ||||||||
| Accession | Primary (citable) accession number: Q0MQI0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


