ID NDUS7_GORGO Reviewed; 213 AA. AC Q0MQH9; DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 19-SEP-2006, sequence version 1. DT 27-MAR-2024, entry version 90. DE RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; DE EC=7.1.1.2 {ECO:0000250|UniProtKB:O75251}; DE AltName: Full=Complex I-20kD; DE Short=CI-20kD; DE AltName: Full=NADH-ubiquinone oxidoreductase 20 kDa subunit; DE Flags: Precursor; GN Name=NDUFS7; OS Gorilla gorilla gorilla (Western lowland gorilla). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Gorilla. OX NCBI_TaxID=9595; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=16828987; DOI=10.1016/j.gene.2006.03.015; RA Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., RA Wallace D.C.; RT "Adaptive selection of mitochondrial complex I subunits during primate RT radiation."; RL Gene 378:11-18(2006). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity of complex I. CC {ECO:0000250|UniProtKB:O75251}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000250|UniProtKB:O75251}; CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305}; CC Note=Binds 1 [4Fe-4S] cluster. {ECO:0000305}; CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex CC I) which is composed of 45 different subunits (By similarity). This is CC a component of the iron-sulfur (IP) fragment of the enzyme (By CC similarity). {ECO:0000250|UniProtKB:P42026}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000250|UniProtKB:P42026}; Peripheral membrane protein CC {ECO:0000250|UniProtKB:P42026}; Matrix side CC {ECO:0000250|UniProtKB:P42026}. CC -!- PTM: Hydroxylated ar Arg-111 by NDUFAF5 early in the pathway of CC assembly of complex I, before the formation of the juncture between CC peripheral and membrane arms. {ECO:0000250|UniProtKB:O75251}. CC -!- SIMILARITY: Belongs to the complex I 20 kDa subunit family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ885655; ABH12164.1; -; mRNA. DR RefSeq; NP_001266514.1; NM_001279585.1. DR AlphaFoldDB; Q0MQH9; -. DR SMR; Q0MQH9; -. DR STRING; 9593.ENSGGOP00000029511; -. DR GeneID; 101149494; -. DR KEGG; ggo:101149494; -. DR CTD; 374291; -. DR eggNOG; KOG1687; Eukaryota. DR HOGENOM; CLU_055737_1_2_1; -. DR InParanoid; Q0MQH9; -. DR OrthoDB; 33762at2759; -. DR Proteomes; UP000001519; Unplaced. DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB. DR GO; GO:0048038; F:quinone binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central. DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB. DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB. DR Gene3D; 3.40.50.12280; -; 1. DR HAMAP; MF_01356; NDH1_NuoB; 1. DR InterPro; IPR006137; NADH_UbQ_OxRdtase-like_20kDa. DR InterPro; IPR006138; NADH_UQ_OxRdtase_20Kd_su. DR NCBIfam; TIGR01957; nuoB_fam; 1. DR PANTHER; PTHR11995; NADH DEHYDROGENASE; 1. DR PANTHER; PTHR11995:SF14; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL; 1. DR Pfam; PF01058; Oxidored_q6; 1. DR SUPFAM; SSF56770; HydA/Nqo6-like; 1. DR PROSITE; PS01150; COMPLEX1_20K; 1. PE 2: Evidence at transcript level; KW 4Fe-4S; Electron transport; Hydroxylation; Iron; Iron-sulfur; Membrane; KW Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; KW Oxidoreductase; Reference proteome; Respiratory chain; Transit peptide; KW Translocase; Transport; Ubiquinone. FT TRANSIT 1..38 FT /note="Mitochondrion" FT /evidence="ECO:0000250|UniProtKB:P42026" FT CHAIN 39..213 FT /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein FT 7, mitochondrial" FT /id="PRO_0000251872" FT REGION 32..53 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 88 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /evidence="ECO:0000255" FT BINDING 89 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /evidence="ECO:0000255" FT BINDING 153 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /evidence="ECO:0000255" FT BINDING 183 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /evidence="ECO:0000255" FT MOD_RES 111 FT /note="Hydroxyarginine" FT /evidence="ECO:0000250|UniProtKB:P42026" SQ SEQUENCE 213 AA; 23486 MW; 78F97AAC14A92ED8 CRC64; MAALSAPGLC GFRILGLRSS VGTAVQARGV HQSVATDGPS STQPALPKAR AVAPKPSSRG EYVVAKLDDL VNWARRSSLW PMTFGLACCA VEMMHMAAPR YDMDRFGVVF RASPRQSDVM IVAGTLTNKM APALRKVYDQ MPEPRYVVSM GSCANGGGYY HYSYSVVRGC DRIVPVDIYI PGCPPTAEAL LYGILQLQRK IKRERRLQIW YRR //