Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0MQH9 (NDUS7_GORGO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-20kD
Short name=CI-20kD
NADH-ubiquinone oxidoreductase 20 kDa subunit
Gene names
Name:NDUFS7
OrganismGorilla gorilla gorilla (Lowland gorilla) [Reference proteome]
Taxonomic identifier9595 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. HAMAP-Rule MF_01356

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01356

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01356

Cofactor

Binds 1 4Fe-4S cluster Potential.

Subunit structure

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity.

Subcellular location

Mitochondrion By similarity HAMAP-Rule MF_01356.

Sequence similarities

Belongs to the complex I 20 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3838Mitochondrion By similarity
Chain39 – 213175NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial HAMAP-Rule MF_01356
PRO_0000251872

Sites

Metal binding881Iron-sulfur (4Fe-4S) Potential
Metal binding891Iron-sulfur (4Fe-4S) Potential
Metal binding1531Iron-sulfur (4Fe-4S) Potential
Metal binding1831Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0MQH9 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: 78F97AAC14A92ED8

FASTA21323,486
        10         20         30         40         50         60 
MAALSAPGLC GFRILGLRSS VGTAVQARGV HQSVATDGPS STQPALPKAR AVAPKPSSRG 

        70         80         90        100        110        120 
EYVVAKLDDL VNWARRSSLW PMTFGLACCA VEMMHMAAPR YDMDRFGVVF RASPRQSDVM 

       130        140        150        160        170        180 
IVAGTLTNKM APALRKVYDQ MPEPRYVVSM GSCANGGGYY HYSYSVVRGC DRIVPVDIYI 

       190        200        210 
PGCPPTAEAL LYGILQLQRK IKRERRLQIW YRR 

« Hide

References

[1]"Adaptive selection of mitochondrial complex I subunits during primate radiation."
Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.
Gene 378:11-18(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ885655 mRNA. Translation: ABH12164.1.
RefSeqNP_001266514.1. NM_001279585.1.

3D structure databases

ProteinModelPortalQ0MQH9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGGOT00000002821; ENSGGOP00000002763; ENSGGOG00000002804.
GeneID101149494.

Organism-specific databases

CTD374291.

Phylogenomic databases

GeneTreeENSGT00390000006565.
HOVERGENHBG001576.
OMAQVRGVHS.

Family and domain databases

Gene3D3.40.50.700. 1 hit.
HAMAPMF_01356. NDH1_NuoB.
InterProIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsTIGR01957. nuoB_fam. 1 hit.
PROSITEPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS7_GORGO
AccessionPrimary (citable) accession number: Q0MQH9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 19, 2006
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families