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Q0MQH9

- NDUS7_GORGO

UniProt

Q0MQH9 - NDUS7_GORGO

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

NDUFS7

Organism
Gorilla gorilla gorilla (Lowland gorilla)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 4Fe-4S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi88 – 881Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi89 – 891Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi153 – 1531Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi183 – 1831Iron-sulfur (4Fe-4S)Sequence Analysis

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    4. quinone binding Source: InterPro

    GO - Biological processi

    1. mitochondrial respiratory chain complex I assembly Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-20kD
    Short name:
    CI-20kD
    NADH-ubiquinone oxidoreductase 20 kDa subunit
    Gene namesi
    Name:NDUFS7
    OrganismiGorilla gorilla gorilla (Lowland gorilla)
    Taxonomic identifieri9595 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
    ProteomesiUP000001519: Chromosome 19

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex I Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3838MitochondrionBy similarityAdd
    BLAST
    Chaini39 – 213175NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialPRO_0000251872Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ0MQH9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 20 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    GeneTreeiENSGT00390000006565.
    HOVERGENiHBG001576.
    OMAiQVRGVHS.

    Family and domain databases

    Gene3Di3.40.50.700. 1 hit.
    HAMAPiMF_01356. NDH1_NuoB.
    InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view]
    PfamiPF01058. Oxidored_q6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
    PROSITEiPS01150. COMPLEX1_20K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0MQH9-1 [UniParc]FASTAAdd to Basket

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    MAALSAPGLC GFRILGLRSS VGTAVQARGV HQSVATDGPS STQPALPKAR    50
    AVAPKPSSRG EYVVAKLDDL VNWARRSSLW PMTFGLACCA VEMMHMAAPR 100
    YDMDRFGVVF RASPRQSDVM IVAGTLTNKM APALRKVYDQ MPEPRYVVSM 150
    GSCANGGGYY HYSYSVVRGC DRIVPVDIYI PGCPPTAEAL LYGILQLQRK 200
    IKRERRLQIW YRR 213
    Length:213
    Mass (Da):23,486
    Last modified:September 19, 2006 - v1
    Checksum:i78F97AAC14A92ED8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ885655 mRNA. Translation: ABH12164.1.
    RefSeqiNP_001266514.1. NM_001279585.1.

    Genome annotation databases

    EnsembliENSGGOT00000002821; ENSGGOP00000002763; ENSGGOG00000002804.
    GeneIDi101149494.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ885655 mRNA. Translation: ABH12164.1 .
    RefSeqi NP_001266514.1. NM_001279585.1.

    3D structure databases

    ProteinModelPortali Q0MQH9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGGOT00000002821 ; ENSGGOP00000002763 ; ENSGGOG00000002804 .
    GeneIDi 101149494.

    Organism-specific databases

    CTDi 374291.

    Phylogenomic databases

    GeneTreei ENSGT00390000006565.
    HOVERGENi HBG001576.
    OMAi QVRGVHS.

    Family and domain databases

    Gene3Di 3.40.50.700. 1 hit.
    HAMAPi MF_01356. NDH1_NuoB.
    InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view ]
    Pfami PF01058. Oxidored_q6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
    PROSITEi PS01150. COMPLEX1_20K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Adaptive selection of mitochondrial complex I subunits during primate radiation."
      Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.
      Gene 378:11-18(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiNDUS7_GORGO
    AccessioniPrimary (citable) accession number: Q0MQH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3