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Q0MQG8

- NDUS3_PANTR

UniProt

Q0MQG8 - NDUS3_PANTR

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Gene

NDUFS3

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    2. NADH dehydrogenase activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of cell growth Source: UniProtKB
    2. negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
    3. reactive oxygen species metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-30kD
    Short name:
    CI-30kD
    NADH-ubiquinone oxidoreductase 30 kDa subunit
    Gene namesi
    Name:NDUFS3
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    Mitochondrion inner membrane By similarity
    Note: Matrix and cytoplasmic side of the mitochondrial inner membrane.By similarity

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex I Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3636MitochondrionBy similarityAdd
    BLAST
    Chaini37 – 264228NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialPRO_0000251860Add
    BLAST

    Proteomic databases

    PRIDEiQ0MQG8.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. Interacts with NDUFAF3.By similarity

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000006209.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0MQG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 30 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0852.
    HOGENOMiHOG000009797.
    HOVERGENiHBG000450.
    InParanoidiQ0MQG8.
    KOiK03936.

    Family and domain databases

    HAMAPiMF_01357. NDH1_NuoC.
    InterProiIPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view]
    PfamiPF00329. Complex1_30kDa. 1 hit.
    [Graphical view]
    ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
    PROSITEiPS00542. COMPLEX1_30K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0MQG8-1 [UniParc]FASTAAdd to Basket

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    MAAAAVARLW WRGILGASAL TRGTGRPSVL LLPVRRESAG ADTRPTVRPR    50
    NDVAHKQLSA FGEYVAEILP KYVQQVQVSC FNELEVCIHP DGVIPVLTFL 100
    RDHTNAQFKS LVDLTAVDVP TRQNRFEIVY NLLSLRFNSR IRVKTYTDEL 150
    TPIESAVSVF KAANWYEREI WDMFGVFFAN HPDLRRILTD YGFEGHPFRK 200
    DFPLSGYVEL RYDDEVKRVV AEPVELAQEF RKFDLNSPWE AFPVYRQPPE 250
    SLKLEAGDKN LMPN 264
    Length:264
    Mass (Da):30,272
    Last modified:September 19, 2006 - v1
    Checksum:iC7326A073ECEF17B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ885666 mRNA. Translation: ABH12175.1.
    RefSeqiNP_001073382.1. NM_001079913.1.
    UniGeneiPtr.3897.

    Genome annotation databases

    GeneIDi451175.
    KEGGiptr:451175.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ885666 mRNA. Translation: ABH12175.1 .
    RefSeqi NP_001073382.1. NM_001079913.1.
    UniGenei Ptr.3897.

    3D structure databases

    ProteinModelPortali Q0MQG8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000006209.

    Proteomic databases

    PRIDEi Q0MQG8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 451175.
    KEGGi ptr:451175.

    Organism-specific databases

    CTDi 4722.

    Phylogenomic databases

    eggNOGi COG0852.
    HOGENOMi HOG000009797.
    HOVERGENi HBG000450.
    InParanoidi Q0MQG8.
    KOi K03936.

    Miscellaneous databases

    NextBioi 20833804.

    Family and domain databases

    HAMAPi MF_01357. NDH1_NuoC.
    InterProi IPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view ]
    Pfami PF00329. Complex1_30kDa. 1 hit.
    [Graphical view ]
    ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
    PROSITEi PS00542. COMPLEX1_30K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Adaptive selection of mitochondrial complex I subunits during primate radiation."
      Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.
      Gene 378:11-18(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiNDUS3_PANTR
    AccessioniPrimary (citable) accession number: Q0MQG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3