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Q0MQG6 (NDUS3_PONPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-30kD
Short name=CI-30kD
NADH-ubiquinone oxidoreductase 30 kDa subunit
Gene names
Name:NDUFS3
OrganismPongo pygmaeus (Bornean orangutan)
Taxonomic identifier9600 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. HAMAP-Rule MF_01357

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01357

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01357

Subunit structure

Complex I is composed of 45 different subunits By similarity. Interacts with NDUFAF3 By similarity.

Subcellular location

Mitochondrion inner membrane By similarity. Note: Matrix and cytoplasmic side of the mitochondrial inner membrane By similarity. HAMAP-Rule MF_01357

Sequence similarities

Belongs to the complex I 30 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3535Mitochondrion By similarity
Chain36 – 263228NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial HAMAP-Rule MF_01357
PRO_0000251861

Sequences

Sequence LengthMass (Da)Tools
Q0MQG6 [UniParc].

Last modified September 19, 2006. Version 1.
Checksum: 6DC44C27645856C5

FASTA26330,168
        10         20         30         40         50         60 
MVAAVARLWW RGLLGASALT RGAGRPSVLL LPVRRESAGA DTRPTVRPRN DVAHQQLSAF 

        70         80         90        100        110        120 
GEYVAEILPK YVQQVQVSCF NELEVCIHPD GVIPVLTFLR DHTNAQFKSL VDLTAVDVPT 

       130        140        150        160        170        180 
RQNRFEIVYN LLSLRFNSRI RVKTYTDELT PIESAVSVFK AANWYEREIW DMFGVFFANH 

       190        200        210        220        230        240 
PDLRRILTDY GFEGHPFRKD FPLSGYVELR YDDEVKRVVA EPVELAQEFR KFDLNSPWEA 

       250        260 
FPVYRQPPES LKLEAGDKKP DAK 

« Hide

References

[1]"Adaptive selection of mitochondrial complex I subunits during primate radiation."
Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.
Gene 378:11-18(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ885668 mRNA. Translation: ABH12177.1.

3D structure databases

ProteinModelPortalQ0MQG6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9600.ENSPPYP00000003782.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0852.
HOGENOMHOG000009797.
HOVERGENHBG000450.
InParanoidQ0MQG6.

Family and domain databases

HAMAPMF_01357. NDH1_NuoC.
InterProIPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR020396. NADH_UbQ_OxRdtase_CS.
[Graphical view]
PfamPF00329. Complex1_30kDa. 1 hit.
[Graphical view]
ProDomPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01961. NuoC_fam. 1 hit.
PROSITEPS00542. COMPLEX1_30K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS3_PONPY
AccessionPrimary (citable) accession number: Q0MQG6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 19, 2006
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families