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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C2

Gene

NDUFC2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C2
Alternative name(s):
Complex I-B14.5b
Short name:
CI-B14.5b
NADH-ubiquinone oxidoreductase subunit B14.5b
Gene namesi
Name:NDUFC2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 75HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002518511 – 119NADH dehydrogenase [ubiquinone] 1 subunit C2Add BLAST119

Proteomic databases

PaxDbiQ0MQF9.

Expressioni

Gene expression databases

BgeeiENSPTRG00000004111.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000007076.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOGENOMiHOG000113753.
HOVERGENiHBG001727.
InParanoidiQ0MQF9.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG091G0ZKK.
TreeFamiTF314723.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0MQF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIARRNPEPL RFLPDEARSL PPPKLTDPRL LYIGFLGYCS GLIDNLIRRR
60 70 80 90 100
PVATAGLHRQ LLYITAFFFA GYYLVKREDY LYAVRDREMF GYMKLHPEDF
110
PEEDKKTYGE IFEKFHPIR
Length:119
Mass (Da):14,173
Last modified:September 19, 2006 - v1
Checksum:i5947DEF1BF5936CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885675 mRNA. Translation: ABH12184.1.
RefSeqiNP_001065249.1. NM_001071781.1.
UniGeneiPtr.505.

Genome annotation databases

EnsembliENSPTRT00000007670; ENSPTRP00000007076; ENSPTRG00000004111.
GeneIDi451445.
KEGGiptr:451445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885675 mRNA. Translation: ABH12184.1.
RefSeqiNP_001065249.1. NM_001071781.1.
UniGeneiPtr.505.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000007076.

Proteomic databases

PaxDbiQ0MQF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000007670; ENSPTRP00000007076; ENSPTRG00000004111.
GeneIDi451445.
KEGGiptr:451445.

Organism-specific databases

CTDi4718.

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOGENOMiHOG000113753.
HOVERGENiHBG001727.
InParanoidiQ0MQF9.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG091G0ZKK.
TreeFamiTF314723.

Gene expression databases

BgeeiENSPTRG00000004111.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUC2_PANTR
AccessioniPrimary (citable) accession number: Q0MQF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 19, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.