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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C2

Gene

NDUFC2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C2
Alternative name(s):
Complex I-B14.5b
Short name:
CI-B14.5b
NADH-ubiquinone oxidoreductase subunit B14.5b
Gene namesi
Name:NDUFC2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 75HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002518511 – 119NADH dehydrogenase [ubiquinone] 1 subunit C2Add BLAST119

Proteomic databases

PaxDbiQ0MQF9.

Expressioni

Gene expression databases

BgeeiENSPTRG00000004111.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000007076.

Structurei

3D structure databases

SMRiQ0MQF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOGENOMiHOG000113753.
HOVERGENiHBG001727.
InParanoidiQ0MQF9.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG091G0ZKK.
TreeFamiTF314723.

Family and domain databases

InterProiView protein in InterPro
IPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiView protein in Pfam
PF06374. NDUF_C2. 1 hit.
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0MQF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIARRNPEPL RFLPDEARSL PPPKLTDPRL LYIGFLGYCS GLIDNLIRRR
60 70 80 90 100
PVATAGLHRQ LLYITAFFFA GYYLVKREDY LYAVRDREMF GYMKLHPEDF
110
PEEDKKTYGE IFEKFHPIR
Length:119
Mass (Da):14,173
Last modified:September 19, 2006 - v1
Checksum:i5947DEF1BF5936CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885675 mRNA. Translation: ABH12184.1.
RefSeqiNP_001065249.1. NM_001071781.1.
UniGeneiPtr.505.

Genome annotation databases

EnsembliENSPTRT00000007670; ENSPTRP00000007076; ENSPTRG00000004111.
GeneIDi451445.
KEGGiptr:451445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885675 mRNA. Translation: ABH12184.1.
RefSeqiNP_001065249.1. NM_001071781.1.
UniGeneiPtr.505.

3D structure databases

SMRiQ0MQF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000007076.

Proteomic databases

PaxDbiQ0MQF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000007670; ENSPTRP00000007076; ENSPTRG00000004111.
GeneIDi451445.
KEGGiptr:451445.

Organism-specific databases

CTDi4718.

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOGENOMiHOG000113753.
HOVERGENiHBG001727.
InParanoidiQ0MQF9.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG091G0ZKK.
TreeFamiTF314723.

Gene expression databases

BgeeiENSPTRG00000004111.

Family and domain databases

InterProiView protein in InterPro
IPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiView protein in Pfam
PF06374. NDUF_C2. 1 hit.
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUC2_PANTR
AccessioniPrimary (citable) accession number: Q0MQF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 19, 2006
Last modified: March 15, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.