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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C2

Gene

NDUFC2

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C2
Alternative name(s):
Complex I-B14.5b
Short name:
CI-B14.5b
NADH-ubiquinone oxidoreductase subunit B14.5b
Gene namesi
Name:NDUFC2
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7520HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119NADH dehydrogenase [ubiquinone] 1 subunit C2PRO_0000251850Add
BLAST

Proteomic databases

PRIDEiQ0MQF8.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ0MQF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG001727.
InParanoidiQ0MQF8.
OMAiGRVPLQF.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0MQF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIARRNPEPL RFLPDEARSL PPPKLTDPRL LYIGFLGYCS GLIDNLIRRR
60 70 80 90 100
PIATAGLHRQ LLYITAFFFA GYYLVKREDY LYAVRDREMF GYMKLHPEDF
110
PEEDKKTYGE IFEKFHPIR
Length:119
Mass (Da):14,188
Last modified:September 19, 2006 - v1
Checksum:i9A47DEE33DC9244D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885676 mRNA. Translation: ABH12185.1.
RefSeqiNP_001266623.1. NM_001279694.1.

Genome annotation databases

GeneIDi101142450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885676 mRNA. Translation: ABH12185.1.
RefSeqiNP_001266623.1. NM_001279694.1.

3D structure databases

ProteinModelPortaliQ0MQF8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ0MQF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101142450.

Organism-specific databases

CTDi4718.

Phylogenomic databases

HOVERGENiHBG001727.
InParanoidiQ0MQF8.
OMAiGRVPLQF.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Adaptive selection of mitochondrial complex I subunits during primate radiation."
    Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.
    Gene 378:11-18(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNDUC2_GORGO
AccessioniPrimary (citable) accession number: Q0MQF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 19, 2006
Last modified: December 9, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.