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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

Gene

NDUFB4

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Alternative name(s):
Complex I-B15
Short name:
CI-B15
NADH-ubiquinone oxidoreductase B15 subunit
Gene namesi
Name:NDUFB4
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei88 – 10518HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 129128NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4PRO_0000251832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei26 – 261PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0MQD5.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000026324.

Structurei

3D structure databases

ProteinModelPortaliQ0MQD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB4 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
GeneTreeiENSGT00390000007133.
HOGENOMiHOG000060241.
HOVERGENiHBG001159.
InParanoidiQ0MQD5.
KOiK03960.
OMAiIGPLFFW.
OrthoDBiEOG70KGRC.
TreeFamiTF328761.

Family and domain databases

InterProiIPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
[Graphical view]
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiPF07225. NDUF_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0MQD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPKYKPSS LRTLPETLDP AEYNISPETR RAQAERLAIR AQLKREYLLQ
60 70 80 90 100
YNDPNRRGLI ENPALLRWAY ARTINVYPNF RPTPKNSLMG ALCGFGPLIF
110 120
IYYIIKTERD RKEKLIQEGK LDRTFHLSY
Length:129
Mass (Da):15,209
Last modified:January 23, 2007 - v3
Checksum:iE5060D0BF46FFF28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885699 mRNA. Translation: ABH12208.1.
RefSeqiNP_001065260.1. NM_001071792.1.
UniGeneiPtr.225.

Genome annotation databases

EnsembliENSPTRT00000028523; ENSPTRP00000026324; ENSPTRG00000015270.
GeneIDi460612.
KEGGiptr:460612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885699 mRNA. Translation: ABH12208.1.
RefSeqiNP_001065260.1. NM_001071792.1.
UniGeneiPtr.225.

3D structure databases

ProteinModelPortaliQ0MQD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000026324.

Proteomic databases

PaxDbiQ0MQD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000028523; ENSPTRP00000026324; ENSPTRG00000015270.
GeneIDi460612.
KEGGiptr:460612.

Organism-specific databases

CTDi4710.

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
GeneTreeiENSGT00390000007133.
HOGENOMiHOG000060241.
HOVERGENiHBG001159.
InParanoidiQ0MQD5.
KOiK03960.
OMAiIGPLFFW.
OrthoDBiEOG70KGRC.
TreeFamiTF328761.

Family and domain databases

InterProiIPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
[Graphical view]
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiPF07225. NDUF_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Adaptive selection of mitochondrial complex I subunits during primate radiation."
    Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.
    Gene 378:11-18(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNDUB4_PANTR
AccessioniPrimary (citable) accession number: Q0MQD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.