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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

Gene

NDUFB4

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Alternative name(s):
Complex I-B15
Short name:
CI-B15
NADH-ubiquinone oxidoreductase B15 subunit
Gene namesi
Name:NDUFB4
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:7988 NDUFB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei88 – 105HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002518322 – 129NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0MQD5

Expressioni

Gene expression databases

BgeeiENSPTRG00000015270

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000026324

Structurei

3D structure databases

ProteinModelPortaliQ0MQD5
SMRiQ0MQD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB4 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUV Eukaryota
ENOG4112CXK LUCA
GeneTreeiENSGT00390000007133
HOGENOMiHOG000060241
HOVERGENiHBG001159
InParanoidiQ0MQD5
KOiK03960
OMAiRWVYARA
OrthoDBiEOG091G1578
TreeFamiTF328761

Family and domain databases

InterProiView protein in InterPro
IPR009866 NADH_UbQ_OxRdtase_NDUFB4_su
PANTHERiPTHR15469 PTHR15469, 1 hit
PfamiView protein in Pfam
PF07225 NDUF_B4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0MQD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPKYKPSS LRTLPETLDP AEYNISPETR RAQAERLAIR AQLKREYLLQ
60 70 80 90 100
YNDPNRRGLI ENPALLRWAY ARTINVYPNF RPTPKNSLMG ALCGFGPLIF
110 120
IYYIIKTERD RKEKLIQEGK LDRTFHLSY
Length:129
Mass (Da):15,209
Last modified:January 23, 2007 - v3
Checksum:iE5060D0BF46FFF28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885699 mRNA Translation: ABH12208.1
RefSeqiNP_001065260.1, NM_001071792.1
UniGeneiPtr.225

Genome annotation databases

EnsembliENSPTRT00000028523; ENSPTRP00000026324; ENSPTRG00000015270
GeneIDi460612
KEGGiptr:460612

Similar proteinsi

Entry informationi

Entry nameiNDUB4_PANTR
AccessioniPrimary (citable) accession number: Q0MQD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 80 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health