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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

Gene

NDUFB4

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Alternative name(s):
Complex I-B15
Short name:
CI-B15
NADH-ubiquinone oxidoreductase B15 subunit
Gene namesi
Name:NDUFB4
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei88 – 105HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002518322 – 129NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei26PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ0MQD5.

Expressioni

Gene expression databases

BgeeiENSPTRG00000015270.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000026324.

Structurei

3D structure databases

ProteinModelPortaliQ0MQD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB4 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
GeneTreeiENSGT00390000007133.
HOGENOMiHOG000060241.
HOVERGENiHBG001159.
InParanoidiQ0MQD5.
KOiK03960.
OMAiRWVYARA.
OrthoDBiEOG090A0EIQ.
TreeFamiTF328761.

Family and domain databases

InterProiView protein in InterPro
IPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiView protein in Pfam
PF07225. NDUF_B4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0MQD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPKYKPSS LRTLPETLDP AEYNISPETR RAQAERLAIR AQLKREYLLQ
60 70 80 90 100
YNDPNRRGLI ENPALLRWAY ARTINVYPNF RPTPKNSLMG ALCGFGPLIF
110 120
IYYIIKTERD RKEKLIQEGK LDRTFHLSY
Length:129
Mass (Da):15,209
Last modified:January 23, 2007 - v3
Checksum:iE5060D0BF46FFF28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885699 mRNA. Translation: ABH12208.1.
RefSeqiNP_001065260.1. NM_001071792.1.
UniGeneiPtr.225.

Genome annotation databases

EnsembliENSPTRT00000028523; ENSPTRP00000026324; ENSPTRG00000015270.
GeneIDi460612.
KEGGiptr:460612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885699 mRNA. Translation: ABH12208.1.
RefSeqiNP_001065260.1. NM_001071792.1.
UniGeneiPtr.225.

3D structure databases

ProteinModelPortaliQ0MQD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000026324.

Proteomic databases

PaxDbiQ0MQD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000028523; ENSPTRP00000026324; ENSPTRG00000015270.
GeneIDi460612.
KEGGiptr:460612.

Organism-specific databases

CTDi4710.

Phylogenomic databases

eggNOGiENOG410IZUV. Eukaryota.
ENOG4112CXK. LUCA.
GeneTreeiENSGT00390000007133.
HOGENOMiHOG000060241.
HOVERGENiHBG001159.
InParanoidiQ0MQD5.
KOiK03960.
OMAiRWVYARA.
OrthoDBiEOG090A0EIQ.
TreeFamiTF328761.

Gene expression databases

BgeeiENSPTRG00000015270.

Family and domain databases

InterProiView protein in InterPro
IPR009866. NADH_UbQ_OxRdtase_NDUFB4_su.
PANTHERiPTHR15469. PTHR15469. 1 hit.
PfamiView protein in Pfam
PF07225. NDUF_B4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB4_PANTR
AccessioniPrimary (citable) accession number: Q0MQD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 23, 2007
Last modified: February 15, 2017
This is version 74 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.