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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Gene

NDUFA2

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Alternative name(s):
Complex I-B8
Short name:
CI-B8
NADH-ubiquinone oxidoreductase B8 subunit
Gene namesi
Name:NDUFA2
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002517992 – 99NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Disulfide bondi24 ↔ 58Redox-activeBy similarity
Modified residuei64N6-acetyllysine; alternateBy similarity1
Modified residuei64N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond

Expressioni

Gene expression databases

BgeeiENSGGOG00000013369

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000013040

Structurei

3D structure databases

ProteinModelPortaliQ0MQ92
SMRiQ0MQ92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA2 subunit family.Curated

Phylogenomic databases

HOVERGENiHBG082012
InParanoidiQ0MQ92
OMAiREIRILC
OrthoDBiEOG091G10SA

Family and domain databases

InterProiView protein in InterPro
IPR016464 NADH_Ub_cplx-1_asu_su-2
IPR007741 Ribosome/NADH_DH
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12878 PTHR12878, 1 hit
PfamiView protein in Pfam
PF05047 L51_S25_CI-B8, 1 hit
PIRSFiPIRSF005822 NDUA2, 1 hit
SMARTiView protein in SMART
SM00916 L51_S25_CI-B8, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0MQ92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAASRGI GAKLGLREIR IHLCQRSPGS RGVRDFIEKR YVELKKANSD
60 70 80 90
LPILIRECSD VQPKLWARYA FGQETNVPLN NFSADQVTRA LENVLSGKA
Length:99
Mass (Da):10,954
Last modified:January 23, 2007 - v3
Checksum:i43D3824CA226431A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885742 mRNA Translation: ABH12251.1
RefSeqiNP_001266516.1, NM_001279587.1

Genome annotation databases

GeneIDi101147705

Similar proteinsi

Entry informationi

Entry nameiNDUA2_GORGO
AccessioniPrimary (citable) accession number: Q0MQ92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health