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Protein

Complex I intermediate-associated protein 30, mitochondrial

Gene

NDUFAF1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).By similarity

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Complex I intermediate-associated protein 30, mitochondrial
Alternative name(s):
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1
Gene namesi
Name:NDUFAF1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionSequence analysisAdd
BLAST
Chaini25 – 327303Complex I intermediate-associated protein 30, mitochondrialPRO_0000251469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei318 – 3181PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0MQ84.

Interactioni

Subunit structurei

Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, CIA30, ECSIT, and ACAD9 (By similarity). Interacts with ECSIT (By similarity). Interacts with ACAD9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000011848.

Family & Domainsi

Sequence similaritiesi

Belongs to the CIA30 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2435. Eukaryota.
ENOG410XQPB. LUCA.
HOGENOMiHOG000231763.
HOVERGENiHBG050960.
InParanoidiQ0MQ84.
KOiK18159.

Family and domain databases

InterProiIPR008979. Galactose-bd-like.
IPR013857. NADH-UbQ_OxRdtase-assoc_prot30.
[Graphical view]
PfamiPF08547. CIA30. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0MQ84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVHKLLRG TYFLRKFXKP TSALYPFLGI RFAEYSSSLQ KPVASPGKAS
60 70 80 90 100
SQRKTEGDLQ GDHQKEVALD ITSSEEKPDV SFDKAIRDEA MYHFRHLKDE
110 120 130 140 150
IVDHWRGPEG HPLHEVLLEQ AKVVWQFRGK EDLDKWTVTS DKTIGGRSEV
160 170 180 190 200
FLKMGKNNQS ALLYGTLSSE APQDGESTRS GYCAMISRIP RGAFERKMSY
210 220 230 240 250
DWSQFNTLYL RVRGDGRPWM VNIKEDTDFF QRTNQMYSYF MFTRGGPYWQ
260 270 280 290 300
EVKIPFSKFF FSNRGRIRDV QHELPLDKIS SIGFTLADKV DGPFFLEIDF
310 320
IGVFTDPAHT EEFAYENSPE LNPRLFK
Length:327
Mass (Da):37,830
Last modified:September 19, 2006 - v1
Checksum:iB8D40B7A77BC16AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885750 mRNA. Translation: ABH12259.1.
RefSeqiNP_001073392.1. NM_001079923.1.
UniGeneiPtr.1775.

Genome annotation databases

GeneIDi739838.
KEGGiptr:739838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ885750 mRNA. Translation: ABH12259.1.
RefSeqiNP_001073392.1. NM_001079923.1.
UniGeneiPtr.1775.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000011848.

Proteomic databases

PaxDbiQ0MQ84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi739838.
KEGGiptr:739838.

Organism-specific databases

CTDi51103.

Phylogenomic databases

eggNOGiKOG2435. Eukaryota.
ENOG410XQPB. LUCA.
HOGENOMiHOG000231763.
HOVERGENiHBG050960.
InParanoidiQ0MQ84.
KOiK18159.

Family and domain databases

InterProiIPR008979. Galactose-bd-like.
IPR013857. NADH-UbQ_OxRdtase-assoc_prot30.
[Graphical view]
PfamiPF08547. CIA30. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Adaptive selection of mitochondrial complex I subunits during primate radiation."
    Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.
    Gene 378:11-18(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCIA30_PANTR
AccessioniPrimary (citable) accession number: Q0MQ84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 19, 2006
Last modified: June 8, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.