Q0KL02 (TRIO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Triple functional domain protein
EC=2.7.11.1

Gene names

Name:

Trio

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	3102 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts to form a complex with leukocyte antigen related protein By similarity.
Subcellular location	Cytoplasm. Note: Isoform 2 localizes to early endosomes. Ref.1
Tissue specificity	Widespread in the brain, with more intense signals in the hippocampus, olfactory bulb, cortical layers and cerebellum. Isoform 2 is predominantly expressed in Purkinje neurons of brain. Ref.1
Domain	The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 CRAL-TRIO domain. Contains 2 DH (DBL-homology) domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 PH domains. Contains 1 protein kinase domain. Contains 1 SH3 domain. Contains 6 spectrin repeats.
Sequence caution	The sequence BAE32258.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat SH3 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Guanine-nucleotide releasing factor Kinase Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q0KL02-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q0KL02-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1890-1908: ASSRLLVRPTSSETPSAAE → HYVDLCSVSVLAQFPYLSI
     1909-3102: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q0KL02-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2548-2548: G → GS
     2549-2568: EGSSSSNISTMLVTHEYTAV → VRVPGSLRPSTPPPLSRQLF
     2569-3102: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q0KL02-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2548-2548: G → GS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3102	3102	Triple functional domain protein		PRO_0000278474
Regions
	Domain	65 – 210	146	CRAL-TRIO
	Repeat	218 – 338	121	Spectrin 1
	Repeat	340 – 446	107	Spectrin 2
	Repeat	566 – 672	107	Spectrin 3
	Repeat	673 – 784	112	Spectrin 4
	Repeat	907 – 1012	106	Spectrin 5
	Repeat	1138 – 1244	107	Spectrin 6
	Domain	1292 – 1467	176	DH 1
	Domain	1479 – 1591	113	PH 1
	Domain	1656 – 1721	66	SH3
	Domain	1969 – 2145	177	DH 2
	Domain	2157 – 2271	115	PH 2
	Domain	2688 – 2778	91	Ig-like C2-type
	Domain	2799 – 3053	255	Protein kinase
	Nucleotide binding	2805 – 2813	9	ATP By similarity
	Compositional bias	715 – 718	4	Poly-Gln
	Compositional bias	1845 – 1850	6	Poly-Ser
	Compositional bias	1951 – 1954	4	Poly-Ser
	Compositional bias	2292 – 2324	33	Gly-rich
	Compositional bias	2296 – 2557	262	Ser-rich
Sites
	Active site	2918	1	Proton acceptor By similarity
	Binding site	2828	1	ATP By similarity
Amino acid modifications
	Modified residue	2282	1	Phosphoserine By similarity
	Modified residue	2458	1	Phosphoserine Ref.5
	Modified residue	2462	1	Phosphoserine By similarity
	Disulfide bond	2709 ↔ 2762		By similarity
Natural variations
	Alternative sequence	1890 – 1908	19	ASSRL…PSAAE → HYVDLCSVSVLAQFPYLSI in isoform 2.		VSP_023308
	Alternative sequence	1909 – 3102	1194	Missing in isoform 2.		VSP_023309
	Alternative sequence	2548	1	G → GS in isoform 3 and isoform 4.		VSP_037863
	Alternative sequence	2549 – 2568	20	EGSSS…EYTAV → VRVPGSLRPSTPPPLSRQLF in isoform 3.		VSP_037864
	Alternative sequence	2569 – 3102	534	Missing in isoform 3.		VSP_037865
Experimental info
	Mutagenesis	1427	1	Q → A: Abolishes Rac1 activation; when associated with E-1435. Ref.1
	Mutagenesis	1435	1	L → E: Abolishes Rac1 activation; when associated with A-1427. Ref.1
	Sequence conflict	2863	1	E → K in BAE32258. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 1, 2009. Version 3. Checksum: 8E8F7C44CB4F72D0	FASTA	3,102	347,861
	10 20 30 40 50 60 MSGSSGGATA PAASSGPAAA ASAAGSGCGG GAGEGAEEAA KDLADIAAFF RSGFRKNDEM 70 80 90 100 110 120 KAMDVLPILK EKVAYLSGGR DKRGGPILTF PARSNHDRIR QEDLRRLISY LACIPSEEVC 130 140 150 160 170 180 KRGFTVIVDM RGSKWDSIKP LLKILQESFP CCIHIALIIK PDNFWQKQRT NFGSSKFEFE 190 200 210 220 230 240 TNMVSLEGLT KVVDPSQLTP EFDGCLEYNH EEWIEIRVAF EEYISNAAHM LSRLEELQDV 250 260 270 280 290 300 LAKKELPQDL EGARNMIDEH SQLKKKVIKA PIEDLDLEGQ KLLQRIQSSD SFPKKNSGSG 310 320 330 340 350 360 NADLQNLLPK VSTMLDRLHS TRQHLHQMWH VRKLKLDQCF QLRLFEQDAE KMFDWITHNK 370 380 390 400 410 420 GLFLNSYTEI GTSHPHAMEL QTQHNHFAMN CMNVYVNINR IMSVANRLVE SGHYASQQIK 430 440 450 460 470 480 QIANQLEQEW KAFAAALDER STLLDMSSIF HQKAEKYMSN VDSWCKACGE VDLPSELQDL 490 500 510 520 530 540 EDAIHHHQGI YEHITLAYSE VSQDGKSLLD KLQRPLTPGS SDSLTASANY SKAVHHVLDV 550 560 570 580 590 600 IHEVLHHQRQ LENIWQHRKV RLHQRLQLCV FQQDVQQVLD WIENHGEAFL SKHTGVGKSL 610 620 630 640 650 660 HRARALQKRH EDFEEVAQNT YTNADKLLEA AEQLAQTGEC DPEEIYQAAH QLEDRIQDFV 670 680 690 700 710 720 RRVEQRKILL DMSVSFHTHV KELWTWLEEL QKELLDDVYA ESVEAVQDLI KRFGQQQQTT 730 740 750 760 770 780 LQVTVNVIKE GEDLIQQLRD SAISSNKTPH NSSINHIETV LQQLDEAQSQ MEELFQERKI 790 800 810 820 830 840 KLELFLQLRI FERDAIDIIS DLESWNDELS QQMNDFDTED LTIAEQRLQH HADKALTMNN 850 860 870 880 890 900 LTFDVIHQGQ DLLQYVNEVQ ASGVELLCDR DVDMATRVQD LLEFLHEKQQ ELDLAAEQHR 910 920 930 940 950 960 KHLEQCVQLR HLQAEVKQVL GWIRNGESML NAGLITASSL QEAEQLQREH EQFQHAIEKT 970 980 990 1000 1010 1020 HQSALQVQQK AEAMLQANHY DMDMIRDCAE KVASHWQQLM LKMEDRLKLV NASVAFYKTS 1030 1040 1050 1060 1070 1080 EQVCSVLESL EQEYKREEDW CGGADKLGPN SETDHVTPMI SKHLEQKEAF LKACTLARRN 1090 1100 1110 1120 1130 1140 ADVFLKYLHR NSVSMPGMVT HIKAPEQQVK NILNELFQRE NRVLHYWTMR KRRLDQCQQY 1150 1160 1170 1180 1190 1200 VVFERSAKQA LEWIHDNGEF YLSTHTSTGS SIQHTQELLK EHEEFQITAK QTKERVKLLI 1210 1220 1230 1240 1250 1260 QLADGFCEKG HAHAAEIKKC VTAVDKRYRD FSLRMEKYRT SLEKALGISS DSNKSSKSLQ 1270 1280 1290 1300 1310 1320 LDIIPASIPG SEVKLRDAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW 1330 1340 1350 1360 1370 1380 EMTSGVEEIP PGIVNKELII FGNMQEIYEF HNNIFLKELE KYEQLPEDVG HCFVTWADKF 1390 1400 1410 1420 1430 1440 QMYVTYCKNK PDSTQLILEH AGSYFDEIQQ RHGLANSISS YLIKPVQRIT KYQLLLKELL 1450 1460 1470 1480 1490 1500 TCCEEGKGEI KDGLEVMLSV PKRANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL 1510 1520 1530 1540 1550 1560 IRKGRERHLF LFEMSLVFSK EVKDSSGRSK YLYKSKLFTS ELGVTEHVEG DPCKFALWVG 1570 1580 1590 1600 1610 1620 RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTVHLRGA LKEPIHIPKT APAARQKGRR 1630 1640 1650 1660 1670 1680 DGEDLDSQGD GSSQPDTISI ASRTSQNTLD SDKLSGGCEL TVVIHDFTAC NSNELTIRRG 1690 1700 1710 1720 1730 1740 QTVEVLERPH DKPDWCLVRT TDRSPAAEGL VPCGSLCIAH SRSSMEMEGI FNHKDSLSVS 1750 1760 1770 1780 1790 1800 SNDASPPASV ASLQPHMIGA QSSPGPKRPG NTLRKWLTSP VRRLSSGKAD GHAKKLAHKH 1810 1820 1830 1840 1850 1860 KKSREVRKSA DAGSQKDSDD SAATPQDETI EERGRNEGLS SGTLSKSSSS GMQSCGEEEG 1870 1880 1890 1900 1910 1920 EEGADAVPLP PPMAIQQHSL LQPDSQDDKA SSRLLVRPTS SETPSAAELV SAIEELVKSK 1930 1940 1950 1960 1970 1980 MALEDRPSSL LVDQGDSSSP SFNPSDNSLL SSSSPIDEME ERKCSSLKRR HYVLQELVET 1990 2000 2010 2020 2030 2040 ERDYVRDLGC VVEGYMALMK EDGVPDDMKG KDKIVFGNIH QIYDWHRDFF LGELEKCLED 2050 2060 2070 2080 2090 2100 PEKLGSLFVK HERRLHMYIV YCQNKPKSEH IVSEYIDTFF EDLKQRLGHR LQLTDLLIKP 2110 2120 2130 2140 2150 2160 VQRIMKYQLL LKDFLKYSKK ASLDTSELEK AVEVMCIVPK RCNDMMNVGR LQGFDGKIVA 2170 2180 2190 2200 2210 2220 QGKLLLQDTF LVTDQDAGLL PRCKERRVFL FEQIVIFSEP LDKKKGFSMP GFLFKNSIKV 2230 2240 2250 2260 2270 2280 SCLCLEENVE SDPCKFALTS RTGDAVETFV LHSSSPSVRQ TWIHEINQIL ENQRNFLNAL 2290 2300 2310 2320 2330 2340 TSPIEYQRNH SGGGGSGSGG SSGGGGGSGG SGASSGGSSS HGSGPSSCSS GPSSSRSRPS 2350 2360 2370 2380 2390 2400 RIPQPVRHHP PMLVSSAASS QAEADKMSGM SAPSPSLPTP SSSLALEASL GQPSRLPLSG 2410 2420 2430 2440 2450 2460 DSEGHERETE PIPKMKVMES PRKAPGSTSG TSQDGNTKDA RGNLGSLPLG KTRPGAVSPL 2470 2480 2490 2500 2510 2520 NSPLSTTFPS PFGKEAFPPS SPLQKGGSFW SSIPASPASR PSSFTFPGDS DSLQRQTHRH 2530 2540 2550 2560 2570 2580 AAPSKDTDRM STCSSASEQS VQSTQSNGEG SSSSNISTML VTHEYTAVKE DEINVYQGEV 2590 2600 2610 2620 2630 2640 VQILASNQQN MFLVFRAATD QCPAAEGWIP GFVLGHTSAV IMENPDGTLK KSTSWHTALR 2650 2660 2670 2680 2690 2700 LRKKSEKKDK DGKRDGKLEN GYRKPREGLS NKVSVKLLNP NYIYDVPPEF VIPLSEVTCE 2710 2720 2730 2740 2750 2760 TGETVVFRCR VCGRPKASIT WKGPEHNTLN NDDHYSISYS DIGEATLKII GVSTEDDGIY 2770 2780 2790 2800 2810 2820 TCIAVNDMGS ASSSASLRVL GPGSDGIVVT WKDNFDAFYS EVAELGRGRF AVVKKCDQKG 2830 2840 2850 2860 2870 2880 TKRAVATKFV NKKLMKRDQV THELGILQNL QHPLLVSLLD TFETPTSYVL VLEMADQGRL 2890 2900 2910 2920 2930 2940 LDCVVRWGSL TEGKVRAHLG EVLEAVRYLH NCRIAHLDLK PENILVDQSL AKPTIKLADF 2950 2960 2970 2980 2990 3000 GDAVQLNTTY YIHQLLGNPE FAAPEIILGN PVSLTADTWS VGVLTYVLLS GVSPFLDDSV 3010 3020 3030 3040 3050 3060 EETCLNICRL DFSFPEDYFQ GVSQKAKEFV CFLLQEDPAK RPSAALALQE QWLQAGNGSG 3070 3080 3090 3100 KGTGVLDTSR LTSFIERRKH QNDVRPIRSI KNFLQSRLLP RV
	Isoform 2 [UniParc]. Checksum: CB3E6B6BB738F7F1	FASTA	1,908	217,005
	10 20 30 40 50 60 MSGSSGGATA PAASSGPAAA ASAAGSGCGG GAGEGAEEAA KDLADIAAFF RSGFRKNDEM 70 80 90 100 110 120 KAMDVLPILK EKVAYLSGGR DKRGGPILTF PARSNHDRIR QEDLRRLISY LACIPSEEVC 130 140 150 160 170 180 KRGFTVIVDM RGSKWDSIKP LLKILQESFP CCIHIALIIK PDNFWQKQRT NFGSSKFEFE 190 200 210 220 230 240 TNMVSLEGLT KVVDPSQLTP EFDGCLEYNH EEWIEIRVAF EEYISNAAHM LSRLEELQDV 250 260 270 280 290 300 LAKKELPQDL EGARNMIDEH SQLKKKVIKA PIEDLDLEGQ KLLQRIQSSD SFPKKNSGSG 310 320 330 340 350 360 NADLQNLLPK VSTMLDRLHS TRQHLHQMWH VRKLKLDQCF QLRLFEQDAE KMFDWITHNK 370 380 390 400 410 420 GLFLNSYTEI GTSHPHAMEL QTQHNHFAMN CMNVYVNINR IMSVANRLVE SGHYASQQIK 430 440 450 460 470 480 QIANQLEQEW KAFAAALDER STLLDMSSIF HQKAEKYMSN VDSWCKACGE VDLPSELQDL 490 500 510 520 530 540 EDAIHHHQGI YEHITLAYSE VSQDGKSLLD KLQRPLTPGS SDSLTASANY SKAVHHVLDV 550 560 570 580 590 600 IHEVLHHQRQ LENIWQHRKV RLHQRLQLCV FQQDVQQVLD WIENHGEAFL SKHTGVGKSL 610 620 630 640 650 660 HRARALQKRH EDFEEVAQNT YTNADKLLEA AEQLAQTGEC DPEEIYQAAH QLEDRIQDFV 670 680 690 700 710 720 RRVEQRKILL DMSVSFHTHV KELWTWLEEL QKELLDDVYA ESVEAVQDLI KRFGQQQQTT 730 740 750 760 770 780 LQVTVNVIKE GEDLIQQLRD SAISSNKTPH NSSINHIETV LQQLDEAQSQ MEELFQERKI 790 800 810 820 830 840 KLELFLQLRI FERDAIDIIS DLESWNDELS QQMNDFDTED LTIAEQRLQH HADKALTMNN 850 860 870 880 890 900 LTFDVIHQGQ DLLQYVNEVQ ASGVELLCDR DVDMATRVQD LLEFLHEKQQ ELDLAAEQHR 910 920 930 940 950 960 KHLEQCVQLR HLQAEVKQVL GWIRNGESML NAGLITASSL QEAEQLQREH EQFQHAIEKT 970 980 990 1000 1010 1020 HQSALQVQQK AEAMLQANHY DMDMIRDCAE KVASHWQQLM LKMEDRLKLV NASVAFYKTS 1030 1040 1050 1060 1070 1080 EQVCSVLESL EQEYKREEDW CGGADKLGPN SETDHVTPMI SKHLEQKEAF LKACTLARRN 1090 1100 1110 1120 1130 1140 ADVFLKYLHR NSVSMPGMVT HIKAPEQQVK NILNELFQRE NRVLHYWTMR KRRLDQCQQY 1150 1160 1170 1180 1190 1200 VVFERSAKQA LEWIHDNGEF YLSTHTSTGS SIQHTQELLK EHEEFQITAK QTKERVKLLI 1210 1220 1230 1240 1250 1260 QLADGFCEKG HAHAAEIKKC VTAVDKRYRD FSLRMEKYRT SLEKALGISS DSNKSSKSLQ 1270 1280 1290 1300 1310 1320 LDIIPASIPG SEVKLRDAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW 1330 1340 1350 1360 1370 1380 EMTSGVEEIP PGIVNKELII FGNMQEIYEF HNNIFLKELE KYEQLPEDVG HCFVTWADKF 1390 1400 1410 1420 1430 1440 QMYVTYCKNK PDSTQLILEH AGSYFDEIQQ RHGLANSISS YLIKPVQRIT KYQLLLKELL 1450 1460 1470 1480 1490 1500 TCCEEGKGEI KDGLEVMLSV PKRANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL 1510 1520 1530 1540 1550 1560 IRKGRERHLF LFEMSLVFSK EVKDSSGRSK YLYKSKLFTS ELGVTEHVEG DPCKFALWVG 1570 1580 1590 1600 1610 1620 RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTVHLRGA LKEPIHIPKT APAARQKGRR 1630 1640 1650 1660 1670 1680 DGEDLDSQGD GSSQPDTISI ASRTSQNTLD SDKLSGGCEL TVVIHDFTAC NSNELTIRRG 1690 1700 1710 1720 1730 1740 QTVEVLERPH DKPDWCLVRT TDRSPAAEGL VPCGSLCIAH SRSSMEMEGI FNHKDSLSVS 1750 1760 1770 1780 1790 1800 SNDASPPASV ASLQPHMIGA QSSPGPKRPG NTLRKWLTSP VRRLSSGKAD GHAKKLAHKH 1810 1820 1830 1840 1850 1860 KKSREVRKSA DAGSQKDSDD SAATPQDETI EERGRNEGLS SGTLSKSSSS GMQSCGEEEG 1870 1880 1890 1900 EEGADAVPLP PPMAIQQHSL LQPDSQDDKH YVDLCSVSVL AQFPYLSI
	Isoform 3 [UniParc]. Checksum: 5869317875FB1134	FASTA	2,569	288,709
	10 20 30 40 50 60 MSGSSGGATA PAASSGPAAA ASAAGSGCGG GAGEGAEEAA KDLADIAAFF RSGFRKNDEM 70 80 90 100 110 120 KAMDVLPILK EKVAYLSGGR DKRGGPILTF PARSNHDRIR QEDLRRLISY LACIPSEEVC 130 140 150 160 170 180 KRGFTVIVDM RGSKWDSIKP LLKILQESFP CCIHIALIIK PDNFWQKQRT NFGSSKFEFE 190 200 210 220 230 240 TNMVSLEGLT KVVDPSQLTP EFDGCLEYNH EEWIEIRVAF EEYISNAAHM LSRLEELQDV 250 260 270 280 290 300 LAKKELPQDL EGARNMIDEH SQLKKKVIKA PIEDLDLEGQ KLLQRIQSSD SFPKKNSGSG 310 320 330 340 350 360 NADLQNLLPK VSTMLDRLHS TRQHLHQMWH VRKLKLDQCF QLRLFEQDAE KMFDWITHNK 370 380 390 400 410 420 GLFLNSYTEI GTSHPHAMEL QTQHNHFAMN CMNVYVNINR IMSVANRLVE SGHYASQQIK 430 440 450 460 470 480 QIANQLEQEW KAFAAALDER STLLDMSSIF HQKAEKYMSN VDSWCKACGE VDLPSELQDL 490 500 510 520 530 540 EDAIHHHQGI YEHITLAYSE VSQDGKSLLD KLQRPLTPGS SDSLTASANY SKAVHHVLDV 550 560 570 580 590 600 IHEVLHHQRQ LENIWQHRKV RLHQRLQLCV FQQDVQQVLD WIENHGEAFL SKHTGVGKSL 610 620 630 640 650 660 HRARALQKRH EDFEEVAQNT YTNADKLLEA AEQLAQTGEC DPEEIYQAAH QLEDRIQDFV 670 680 690 700 710 720 RRVEQRKILL DMSVSFHTHV KELWTWLEEL QKELLDDVYA ESVEAVQDLI KRFGQQQQTT 730 740 750 760 770 780 LQVTVNVIKE GEDLIQQLRD SAISSNKTPH NSSINHIETV LQQLDEAQSQ MEELFQERKI 790 800 810 820 830 840 KLELFLQLRI FERDAIDIIS DLESWNDELS QQMNDFDTED LTIAEQRLQH HADKALTMNN 850 860 870 880 890 900 LTFDVIHQGQ DLLQYVNEVQ ASGVELLCDR DVDMATRVQD LLEFLHEKQQ ELDLAAEQHR 910 920 930 940 950 960 KHLEQCVQLR HLQAEVKQVL GWIRNGESML NAGLITASSL QEAEQLQREH EQFQHAIEKT 970 980 990 1000 1010 1020 HQSALQVQQK AEAMLQANHY DMDMIRDCAE KVASHWQQLM LKMEDRLKLV NASVAFYKTS 1030 1040 1050 1060 1070 1080 EQVCSVLESL EQEYKREEDW CGGADKLGPN SETDHVTPMI SKHLEQKEAF LKACTLARRN 1090 1100 1110 1120 1130 1140 ADVFLKYLHR NSVSMPGMVT HIKAPEQQVK NILNELFQRE NRVLHYWTMR KRRLDQCQQY 1150 1160 1170 1180 1190 1200 VVFERSAKQA LEWIHDNGEF YLSTHTSTGS SIQHTQELLK EHEEFQITAK QTKERVKLLI 1210 1220 1230 1240 1250 1260 QLADGFCEKG HAHAAEIKKC VTAVDKRYRD FSLRMEKYRT SLEKALGISS DSNKSSKSLQ 1270 1280 1290 1300 1310 1320 LDIIPASIPG SEVKLRDAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW 1330 1340 1350 1360 1370 1380 EMTSGVEEIP PGIVNKELII FGNMQEIYEF HNNIFLKELE KYEQLPEDVG HCFVTWADKF 1390 1400 1410 1420 1430 1440 QMYVTYCKNK PDSTQLILEH AGSYFDEIQQ RHGLANSISS YLIKPVQRIT KYQLLLKELL 1450 1460 1470 1480 1490 1500 TCCEEGKGEI KDGLEVMLSV PKRANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL 1510 1520 1530 1540 1550 1560 IRKGRERHLF LFEMSLVFSK EVKDSSGRSK YLYKSKLFTS ELGVTEHVEG DPCKFALWVG 1570 1580 1590 1600 1610 1620 RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTVHLRGA LKEPIHIPKT APAARQKGRR 1630 1640 1650 1660 1670 1680 DGEDLDSQGD GSSQPDTISI ASRTSQNTLD SDKLSGGCEL TVVIHDFTAC NSNELTIRRG 1690 1700 1710 1720 1730 1740 QTVEVLERPH DKPDWCLVRT TDRSPAAEGL VPCGSLCIAH SRSSMEMEGI FNHKDSLSVS 1750 1760 1770 1780 1790 1800 SNDASPPASV ASLQPHMIGA QSSPGPKRPG NTLRKWLTSP VRRLSSGKAD GHAKKLAHKH 1810 1820 1830 1840 1850 1860 KKSREVRKSA DAGSQKDSDD SAATPQDETI EERGRNEGLS SGTLSKSSSS GMQSCGEEEG 1870 1880 1890 1900 1910 1920 EEGADAVPLP PPMAIQQHSL LQPDSQDDKA SSRLLVRPTS SETPSAAELV SAIEELVKSK 1930 1940 1950 1960 1970 1980 MALEDRPSSL LVDQGDSSSP SFNPSDNSLL SSSSPIDEME ERKCSSLKRR HYVLQELVET 1990 2000 2010 2020 2030 2040 ERDYVRDLGC VVEGYMALMK EDGVPDDMKG KDKIVFGNIH QIYDWHRDFF LGELEKCLED 2050 2060 2070 2080 2090 2100 PEKLGSLFVK HERRLHMYIV YCQNKPKSEH IVSEYIDTFF EDLKQRLGHR LQLTDLLIKP 2110 2120 2130 2140 2150 2160 VQRIMKYQLL LKDFLKYSKK ASLDTSELEK AVEVMCIVPK RCNDMMNVGR LQGFDGKIVA 2170 2180 2190 2200 2210 2220 QGKLLLQDTF LVTDQDAGLL PRCKERRVFL FEQIVIFSEP LDKKKGFSMP GFLFKNSIKV 2230 2240 2250 2260 2270 2280 SCLCLEENVE SDPCKFALTS RTGDAVETFV LHSSSPSVRQ TWIHEINQIL ENQRNFLNAL 2290 2300 2310 2320 2330 2340 TSPIEYQRNH SGGGGSGSGG SSGGGGGSGG SGASSGGSSS HGSGPSSCSS GPSSSRSRPS 2350 2360 2370 2380 2390 2400 RIPQPVRHHP PMLVSSAASS QAEADKMSGM SAPSPSLPTP SSSLALEASL GQPSRLPLSG 2410 2420 2430 2440 2450 2460 DSEGHERETE PIPKMKVMES PRKAPGSTSG TSQDGNTKDA RGNLGSLPLG KTRPGAVSPL 2470 2480 2490 2500 2510 2520 NSPLSTTFPS PFGKEAFPPS SPLQKGGSFW SSIPASPASR PSSFTFPGDS DSLQRQTHRH 2530 2540 2550 2560 AAPSKDTDRM STCSSASEQS VQSTQSNGSV RVPGSLRPST PPPLSRQLF
	Isoform 4 [UniParc]. Checksum: 3471FAD8B46480A6	FASTA	3,103	347,948
	10 20 30 40 50 60 MSGSSGGATA PAASSGPAAA ASAAGSGCGG GAGEGAEEAA KDLADIAAFF RSGFRKNDEM 70 80 90 100 110 120 KAMDVLPILK EKVAYLSGGR DKRGGPILTF PARSNHDRIR QEDLRRLISY LACIPSEEVC 130 140 150 160 170 180 KRGFTVIVDM RGSKWDSIKP LLKILQESFP CCIHIALIIK PDNFWQKQRT NFGSSKFEFE 190 200 210 220 230 240 TNMVSLEGLT KVVDPSQLTP EFDGCLEYNH EEWIEIRVAF EEYISNAAHM LSRLEELQDV 250 260 270 280 290 300 LAKKELPQDL EGARNMIDEH SQLKKKVIKA PIEDLDLEGQ KLLQRIQSSD SFPKKNSGSG 310 320 330 340 350 360 NADLQNLLPK VSTMLDRLHS TRQHLHQMWH VRKLKLDQCF QLRLFEQDAE KMFDWITHNK 370 380 390 400 410 420 GLFLNSYTEI GTSHPHAMEL QTQHNHFAMN CMNVYVNINR IMSVANRLVE SGHYASQQIK 430 440 450 460 470 480 QIANQLEQEW KAFAAALDER STLLDMSSIF HQKAEKYMSN VDSWCKACGE VDLPSELQDL 490 500 510 520 530 540 EDAIHHHQGI YEHITLAYSE VSQDGKSLLD KLQRPLTPGS SDSLTASANY SKAVHHVLDV 550 560 570 580 590 600 IHEVLHHQRQ LENIWQHRKV RLHQRLQLCV FQQDVQQVLD WIENHGEAFL SKHTGVGKSL 610 620 630 640 650 660 HRARALQKRH EDFEEVAQNT YTNADKLLEA AEQLAQTGEC DPEEIYQAAH QLEDRIQDFV 670 680 690 700 710 720 RRVEQRKILL DMSVSFHTHV KELWTWLEEL QKELLDDVYA ESVEAVQDLI KRFGQQQQTT 730 740 750 760 770 780 LQVTVNVIKE GEDLIQQLRD SAISSNKTPH NSSINHIETV LQQLDEAQSQ MEELFQERKI 790 800 810 820 830 840 KLELFLQLRI FERDAIDIIS DLESWNDELS QQMNDFDTED LTIAEQRLQH HADKALTMNN 850 860 870 880 890 900 LTFDVIHQGQ DLLQYVNEVQ ASGVELLCDR DVDMATRVQD LLEFLHEKQQ ELDLAAEQHR 910 920 930 940 950 960 KHLEQCVQLR HLQAEVKQVL GWIRNGESML NAGLITASSL QEAEQLQREH EQFQHAIEKT 970 980 990 1000 1010 1020 HQSALQVQQK AEAMLQANHY DMDMIRDCAE KVASHWQQLM LKMEDRLKLV NASVAFYKTS 1030 1040 1050 1060 1070 1080 EQVCSVLESL EQEYKREEDW CGGADKLGPN SETDHVTPMI SKHLEQKEAF LKACTLARRN 1090 1100 1110 1120 1130 1140 ADVFLKYLHR NSVSMPGMVT HIKAPEQQVK NILNELFQRE NRVLHYWTMR KRRLDQCQQY 1150 1160 1170 1180 1190 1200 VVFERSAKQA LEWIHDNGEF YLSTHTSTGS SIQHTQELLK EHEEFQITAK QTKERVKLLI 1210 1220 1230 1240 1250 1260 QLADGFCEKG HAHAAEIKKC VTAVDKRYRD FSLRMEKYRT SLEKALGISS DSNKSSKSLQ 1270 1280 1290 1300 1310 1320 LDIIPASIPG SEVKLRDAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW 1330 1340 1350 1360 1370 1380 EMTSGVEEIP PGIVNKELII FGNMQEIYEF HNNIFLKELE KYEQLPEDVG HCFVTWADKF 1390 1400 1410 1420 1430 1440 QMYVTYCKNK PDSTQLILEH AGSYFDEIQQ RHGLANSISS YLIKPVQRIT KYQLLLKELL 1450 1460 1470 1480 1490 1500 TCCEEGKGEI KDGLEVMLSV PKRANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL 1510 1520 1530 1540 1550 1560 IRKGRERHLF LFEMSLVFSK EVKDSSGRSK YLYKSKLFTS ELGVTEHVEG DPCKFALWVG 1570 1580 1590 1600 1610 1620 RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTVHLRGA LKEPIHIPKT APAARQKGRR 1630 1640 1650 1660 1670 1680 DGEDLDSQGD GSSQPDTISI ASRTSQNTLD SDKLSGGCEL TVVIHDFTAC NSNELTIRRG 1690 1700 1710 1720 1730 1740 QTVEVLERPH DKPDWCLVRT TDRSPAAEGL VPCGSLCIAH SRSSMEMEGI FNHKDSLSVS 1750 1760 1770 1780 1790 1800 SNDASPPASV ASLQPHMIGA QSSPGPKRPG NTLRKWLTSP VRRLSSGKAD GHAKKLAHKH 1810 1820 1830 1840 1850 1860 KKSREVRKSA DAGSQKDSDD SAATPQDETI EERGRNEGLS SGTLSKSSSS GMQSCGEEEG 1870 1880 1890 1900 1910 1920 EEGADAVPLP PPMAIQQHSL LQPDSQDDKA SSRLLVRPTS SETPSAAELV SAIEELVKSK 1930 1940 1950 1960 1970 1980 MALEDRPSSL LVDQGDSSSP SFNPSDNSLL SSSSPIDEME ERKCSSLKRR HYVLQELVET 1990 2000 2010 2020 2030 2040 ERDYVRDLGC VVEGYMALMK EDGVPDDMKG KDKIVFGNIH QIYDWHRDFF LGELEKCLED 2050 2060 2070 2080 2090 2100 PEKLGSLFVK HERRLHMYIV YCQNKPKSEH IVSEYIDTFF EDLKQRLGHR LQLTDLLIKP 2110 2120 2130 2140 2150 2160 VQRIMKYQLL LKDFLKYSKK ASLDTSELEK AVEVMCIVPK RCNDMMNVGR LQGFDGKIVA 2170 2180 2190 2200 2210 2220 QGKLLLQDTF LVTDQDAGLL PRCKERRVFL FEQIVIFSEP LDKKKGFSMP GFLFKNSIKV 2230 2240 2250 2260 2270 2280 SCLCLEENVE SDPCKFALTS RTGDAVETFV LHSSSPSVRQ TWIHEINQIL ENQRNFLNAL 2290 2300 2310 2320 2330 2340 TSPIEYQRNH SGGGGSGSGG SSGGGGGSGG SGASSGGSSS HGSGPSSCSS GPSSSRSRPS 2350 2360 2370 2380 2390 2400 RIPQPVRHHP PMLVSSAASS QAEADKMSGM SAPSPSLPTP SSSLALEASL GQPSRLPLSG 2410 2420 2430 2440 2450 2460 DSEGHERETE PIPKMKVMES PRKAPGSTSG TSQDGNTKDA RGNLGSLPLG KTRPGAVSPL 2470 2480 2490 2500 2510 2520 NSPLSTTFPS PFGKEAFPPS SPLQKGGSFW SSIPASPASR PSSFTFPGDS DSLQRQTHRH 2530 2540 2550 2560 2570 2580 AAPSKDTDRM STCSSASEQS VQSTQSNGSE GSSSSNISTM LVTHEYTAVK EDEINVYQGE 2590 2600 2610 2620 2630 2640 VVQILASNQQ NMFLVFRAAT DQCPAAEGWI PGFVLGHTSA VIMENPDGTL KKSTSWHTAL 2650 2660 2670 2680 2690 2700 RLRKKSEKKD KDGKRDGKLE NGYRKPREGL SNKVSVKLLN PNYIYDVPPE FVIPLSEVTC 2710 2720 2730 2740 2750 2760 ETGETVVFRC RVCGRPKASI TWKGPEHNTL NNDDHYSISY SDIGEATLKI IGVSTEDDGI 2770 2780 2790 2800 2810 2820 YTCIAVNDMG SASSSASLRV LGPGSDGIVV TWKDNFDAFY SEVAELGRGR FAVVKKCDQK 2830 2840 2850 2860 2870 2880 GTKRAVATKF VNKKLMKRDQ VTHELGILQN LQHPLLVSLL DTFETPTSYV LVLEMADQGR 2890 2900 2910 2920 2930 2940 LLDCVVRWGS LTEGKVRAHL GEVLEAVRYL HNCRIAHLDL KPENILVDQS LAKPTIKLAD 2950 2960 2970 2980 2990 3000 FGDAVQLNTT YYIHQLLGNP EFAAPEIILG NPVSLTADTW SVGVLTYVLL SGVSPFLDDS 3010 3020 3030 3040 3050 3060 VEETCLNICR LDFSFPEDYF QGVSQKAKEF VCFLLQEDPA KRPSAALALQ EQWLQAGNGS 3070 3080 3090 3100 GKGTGVLDTS RLTSFIERRK HQNDVRPIRS IKNFLQSRLL PRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Solo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation." Sun Y.-J., Nishikawa K., Yuda K., Wang Y.-L., Osaka H., Fukazawa N., Naito A., Wada K., Aoki S. Mol. Cell. Biol. 26:6923-6935(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, MUTAGENESIS OF GLN-1427 AND LEU-1435, SUBCELLULAR LOCATION. Strain: C57BL/6J. Tissue: Cerebellum.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2062-3102 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1145-3102 (ISOFORM 3). Strain: C57BL/6. Tissue: Brain and Olfactory epithelium.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2521-3102 (ISOFORM 4). Strain: NOD. Tissue: Thymus.
[5]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2458, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB106872 mRNA. Translation: BAF30811.1. AC107452 Genomic DNA. No translation available. AC116808 Genomic DNA. No translation available. AC120373 Genomic DNA. No translation available. AC130219 Genomic DNA. No translation available. BC051169 mRNA. Translation: AAH51169.1. BC060724 mRNA. No translation available. AK153924 mRNA. Translation: BAE32258.1. Different initiation.
IPI	IPI00604947. IPI00605176. IPI00943997. IPI00944152.
RefSeq	NP_001074771.1. NM_001081302.1.
UniGene	Mm.485422.
3D structure databases
ProteinModelPortal	Q0KL02.
SMR	Q0KL02. Positions 220-440, 801-1006, 1101-1239, 1290-1594, 1655-1721, 1960-2291, 2558-2615, 2631-3085.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000087714.
PTM databases
PhosphoSite	Q0KL02.
Proteomic databases
PaxDb	Q0KL02.
PRIDE	Q0KL02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000090247; ENSMUSP00000087714; ENSMUSG00000022263.
GeneID	223435.
KEGG	mmu:223435.
UCSC	uc007vjw.1. mouse. uc007vjx.1. mouse.
Organism-specific databases
CTD	7204.
MGI	MGI:1927230. Trio.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00560000076675.
HOGENOM	HOG000044462.
HOVERGEN	HBG108598.
InParanoid	Q0KL02.
KO	K08810.
OMA	IEERGRN.
OrthoDB	EOG4H462T.
Gene expression databases
Bgee	Q0KL02.
CleanEx	MM_TRIO.
Genevestigator	Q0KL02.
Family and domain databases
Gene3D	1.20.900.10. 2 hits. 2.30.29.30. 2 hits. 2.60.40.10. 1 hit. 3.40.525.10. 1 hit.
InterPro	IPR001251. CRAL-TRIO_dom. IPR000219. DH-domain. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. IPR001452. SH3_domain. IPR018159. Spectrin/alpha-actinin. IPR002017. Spectrin_repeat. [Graphical view]
Pfam	PF07679. I-set. 1 hit. PF00069. Pkinase. 1 hit. PF00621. RhoGEF. 2 hits. PF00018. SH3_1. 1 hit. PF00435. Spectrin. 4 hits. [Graphical view]
SMART	SM00408. IGc2. 1 hit. SM00233. PH. 2 hits. SM00325. RhoGEF. 2 hits. SM00220. S_TKc. 1 hit. SM00516. SEC14. 1 hit. SM00326. SH3. 2 hits. SM00150. SPEC. 6 hits. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit. SSF48065. DH-domain. 2 hits. SSF56112. Kinase_like. 1 hit. SSF50044. SH3. 2 hits.
PROSITE	PS50191. CRAL_TRIO. 1 hit. PS00741. DH_1. False negative. PS50010. DH_2. 2 hits. PS50835. IG_LIKE. 1 hit. PS50003. PH_DOMAIN. 2 hits. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRIO. mouse.
NextBio	376714.
SOURCE	Search...

Entry information

Entry name

TRIO_MOUSE

Accession

Primary (citable) accession number: Q0KL02
Secondary accession number(s): Q3U522, Q6P9K6, Q80W23

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	September 1, 2009
Last modified:	May 1, 2013
This is version 65 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program