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Protein

UBX domain-containing protein 2B

Gene

Ubxn2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2B
Alternative name(s):
NSFL1 cofactor p37
p97 cofactor p37
Gene namesi
Name:Ubxn2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915303. Ubxn2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 331330UBX domain-containing protein 2BPRO_0000315229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei59 – 591PhosphothreonineBy similarity
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei234 – 2341PhosphoserineBy similarity
Modified residuei235 – 2351PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ0KL01.
MaxQBiQ0KL01.
PaxDbiQ0KL01.
PRIDEiQ0KL01.

PTM databases

PhosphoSiteiQ0KL01.

Expressioni

Gene expression databases

BgeeiQ0KL01.
GenevisibleiQ0KL01. MM.

Interactioni

Subunit structurei

Interacts with VCP. Does not bind ubiquitin.1 Publication

Protein-protein interaction databases

BioGridi212631. 1 interaction.
IntActiQ0KL01. 2 interactions.
MINTiMINT-4115176.
STRINGi10090.ENSMUSP00000029907.

Structurei

3D structure databases

ProteinModelPortaliQ0KL01.
SMRiQ0KL01. Positions 140-208, 215-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini141 – 20666SEPPROSITE-ProRule annotationAdd
BLAST
Domaini252 – 32978UBXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NSFL1C family.Curated
Contains 1 SEP domain.PROSITE-ProRule annotation
Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000159961.
HOVERGENiHBG054517.
InParanoidiQ0KL01.
OMAiELYEDEM.
OrthoDBiEOG7ZKSBB.
PhylomeDBiQ0KL01.
TreeFamiTF312973.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0KL01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGRAEPE EQERGSSRPR PPSARDLQLA LAELYEDEMK CKSSKPDRST
60 70 80 90 100
PATCRSPRTP PHRLYSGDHK YDGLHIVQPP TGKIVNELFK EAREHGAVPL
110 120 130 140 150
NEATRSSRED KTKSFTGGGY RLGNSFYKRS EYIYGENQLQ DVQVLLKLWR
160 170 180 190 200
NGFSLDDGEL RPYSDPTNAQ FLESVKRGET PLELQRLVHG AQVNLDMEDH
210 220 230 240 250
QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED KSILNAAVLI
260 270 280 290 300
DDSMPTTKIQ IRLADGSRLV QRFNSTHRIL DVRDFIVRSR PEFATTDFIL
310 320 330
VTSFPSKELT DETVTLQEAD ILNTVILQQL K
Length:331
Mass (Da):37,444
Last modified:January 15, 2008 - v2
Checksum:i61AD4AD6FE784FFA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81E → K in BAB28494 (PubMed:16141072).Curated
Sequence conflicti23 – 231S → N in BAC27819 (PubMed:16141072).Curated
Sequence conflicti164 – 1641S → N in BAF30880 (PubMed:17141156).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120715 mRNA. Translation: BAF30880.1.
AK012822 mRNA. Translation: BAB28494.1.
AK028268 mRNA. Translation: BAC25851.1.
AK032332 mRNA. Translation: BAC27819.1.
AK049018 mRNA. Translation: BAC33515.1.
AL772385 Genomic DNA. Translation: CAM21532.1.
BC076632 mRNA. Translation: AAH76632.1.
CCDSiCCDS17949.1.
RefSeqiNP_080810.2. NM_026534.2.
UniGeneiMm.404043.
Mm.427021.

Genome annotation databases

EnsembliENSMUST00000029907; ENSMUSP00000029907; ENSMUSG00000028243.
GeneIDi68053.
KEGGimmu:68053.
UCSCiuc008rxj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120715 mRNA. Translation: BAF30880.1.
AK012822 mRNA. Translation: BAB28494.1.
AK028268 mRNA. Translation: BAC25851.1.
AK032332 mRNA. Translation: BAC27819.1.
AK049018 mRNA. Translation: BAC33515.1.
AL772385 Genomic DNA. Translation: CAM21532.1.
BC076632 mRNA. Translation: AAH76632.1.
CCDSiCCDS17949.1.
RefSeqiNP_080810.2. NM_026534.2.
UniGeneiMm.404043.
Mm.427021.

3D structure databases

ProteinModelPortaliQ0KL01.
SMRiQ0KL01. Positions 140-208, 215-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212631. 1 interaction.
IntActiQ0KL01. 2 interactions.
MINTiMINT-4115176.
STRINGi10090.ENSMUSP00000029907.

PTM databases

PhosphoSiteiQ0KL01.

Proteomic databases

EPDiQ0KL01.
MaxQBiQ0KL01.
PaxDbiQ0KL01.
PRIDEiQ0KL01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029907; ENSMUSP00000029907; ENSMUSG00000028243.
GeneIDi68053.
KEGGimmu:68053.
UCSCiuc008rxj.1. mouse.

Organism-specific databases

CTDi137886.
MGIiMGI:1915303. Ubxn2b.

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000159961.
HOVERGENiHBG054517.
InParanoidiQ0KL01.
OMAiELYEDEM.
OrthoDBiEOG7ZKSBB.
PhylomeDBiQ0KL01.
TreeFamiTF312973.

Miscellaneous databases

ChiTaRSiUbxn2b. mouse.
NextBioi326324.
PROiQ0KL01.
SOURCEiSearch...

Gene expression databases

BgeeiQ0KL01.
GenevisibleiQ0KL01. MM.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis."
    Uchiyama K., Totsukawa G., Puhka M., Kaneko Y., Jokitalo E., Dreveny I., Beuron F., Zhang X., Freemont P., Kondo H.
    Dev. Cell 11:803-816(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH VCP.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Head and Olfactory bulb.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiUBX2B_MOUSE
AccessioniPrimary (citable) accession number: Q0KL01
Secondary accession number(s): Q8BGY8, Q8CCQ0, Q9CZA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 11, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.