Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UBX domain-containing protein 2B

Gene

Ubxn2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2B
Alternative name(s):
NSFL1 cofactor p37
p97 cofactor p37
Gene namesi
Name:Ubxn2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915303 Ubxn2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003152292 – 331UBX domain-containing protein 2BAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei59PhosphothreonineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei234PhosphoserineBy similarity1
Modified residuei235PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ0KL01
MaxQBiQ0KL01
PaxDbiQ0KL01
PeptideAtlasiQ0KL01
PRIDEiQ0KL01

PTM databases

iPTMnetiQ0KL01
PhosphoSitePlusiQ0KL01

Expressioni

Gene expression databases

BgeeiENSMUSG00000028243
GenevisibleiQ0KL01 MM

Interactioni

Subunit structurei

Interacts with VCP. Does not bind ubiquitin.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212631, 2 interactors
IntActiQ0KL01, 2 interactors
MINTiQ0KL01
STRINGi10090.ENSMUSP00000029907

Structurei

3D structure databases

ProteinModelPortaliQ0KL01
SMRiQ0KL01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 206SEPPROSITE-ProRule annotationAdd BLAST66
Domaini252 – 329UBXPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the NSFL1C family.Curated

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00520000055567
HOGENOMiHOG000159961
HOVERGENiHBG054517
InParanoidiQ0KL01
OMAiFIIQSRP
OrthoDBiEOG091G0QFZ
PhylomeDBiQ0KL01
TreeFamiTF312973

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00553 SEP, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0KL01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGRAEPE EQERGSSRPR PPSARDLQLA LAELYEDEMK CKSSKPDRST
60 70 80 90 100
PATCRSPRTP PHRLYSGDHK YDGLHIVQPP TGKIVNELFK EAREHGAVPL
110 120 130 140 150
NEATRSSRED KTKSFTGGGY RLGNSFYKRS EYIYGENQLQ DVQVLLKLWR
160 170 180 190 200
NGFSLDDGEL RPYSDPTNAQ FLESVKRGET PLELQRLVHG AQVNLDMEDH
210 220 230 240 250
QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED KSILNAAVLI
260 270 280 290 300
DDSMPTTKIQ IRLADGSRLV QRFNSTHRIL DVRDFIVRSR PEFATTDFIL
310 320 330
VTSFPSKELT DETVTLQEAD ILNTVILQQL K
Length:331
Mass (Da):37,444
Last modified:January 15, 2008 - v2
Checksum:i61AD4AD6FE784FFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8E → K in BAB28494 (PubMed:16141072).Curated1
Sequence conflicti23S → N in BAC27819 (PubMed:16141072).Curated1
Sequence conflicti164S → N in BAF30880 (PubMed:17141156).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120715 mRNA Translation: BAF30880.1
AK012822 mRNA Translation: BAB28494.1
AK028268 mRNA Translation: BAC25851.1
AK032332 mRNA Translation: BAC27819.1
AK049018 mRNA Translation: BAC33515.1
AL772385 Genomic DNA No translation available.
BC076632 mRNA Translation: AAH76632.1
CCDSiCCDS17949.1
RefSeqiNP_080810.2, NM_026534.2
UniGeneiMm.404043
Mm.427021

Genome annotation databases

EnsembliENSMUST00000029907; ENSMUSP00000029907; ENSMUSG00000028243
GeneIDi68053
KEGGimmu:68053
UCSCiuc008rxj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiUBX2B_MOUSE
AccessioniPrimary (citable) accession number: Q0KL01
Secondary accession number(s): Q8BGY8, Q8CCQ0, Q9CZA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health