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Protein

UBX domain-containing protein 2B

Gene

Ubxn2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2B
Alternative name(s):
NSFL1 cofactor p37
p97 cofactor p37
Gene namesi
Name:Ubxn2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1915303. Ubxn2b.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003152292 – 331UBX domain-containing protein 2BAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei59PhosphothreonineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei234PhosphoserineBy similarity1
Modified residuei235PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ0KL01.
MaxQBiQ0KL01.
PaxDbiQ0KL01.
PeptideAtlasiQ0KL01.
PRIDEiQ0KL01.

PTM databases

iPTMnetiQ0KL01.
PhosphoSitePlusiQ0KL01.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028243.
GenevisibleiQ0KL01. MM.

Interactioni

Subunit structurei

Interacts with VCP. Does not bind ubiquitin.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212631. 1 interactor.
IntActiQ0KL01. 2 interactors.
MINTiMINT-4115176.
STRINGi10090.ENSMUSP00000029907.

Structurei

3D structure databases

ProteinModelPortaliQ0KL01.
SMRiQ0KL01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 206SEPPROSITE-ProRule annotationAdd BLAST66
Domaini252 – 329UBXPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the NSFL1C family.Curated

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000159961.
HOVERGENiHBG054517.
InParanoidiQ0KL01.
OMAiFIIQSRP.
OrthoDBiEOG091G0QFZ.
PhylomeDBiQ0KL01.
TreeFamiTF312973.

Family and domain databases

InterProiView protein in InterPro
IPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
PfamiView protein in Pfam
PF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
SMARTiView protein in SMART
SM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0KL01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGRAEPE EQERGSSRPR PPSARDLQLA LAELYEDEMK CKSSKPDRST
60 70 80 90 100
PATCRSPRTP PHRLYSGDHK YDGLHIVQPP TGKIVNELFK EAREHGAVPL
110 120 130 140 150
NEATRSSRED KTKSFTGGGY RLGNSFYKRS EYIYGENQLQ DVQVLLKLWR
160 170 180 190 200
NGFSLDDGEL RPYSDPTNAQ FLESVKRGET PLELQRLVHG AQVNLDMEDH
210 220 230 240 250
QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED KSILNAAVLI
260 270 280 290 300
DDSMPTTKIQ IRLADGSRLV QRFNSTHRIL DVRDFIVRSR PEFATTDFIL
310 320 330
VTSFPSKELT DETVTLQEAD ILNTVILQQL K
Length:331
Mass (Da):37,444
Last modified:January 15, 2008 - v2
Checksum:i61AD4AD6FE784FFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8E → K in BAB28494 (PubMed:16141072).Curated1
Sequence conflicti23S → N in BAC27819 (PubMed:16141072).Curated1
Sequence conflicti164S → N in BAF30880 (PubMed:17141156).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120715 mRNA. Translation: BAF30880.1.
AK012822 mRNA. Translation: BAB28494.1.
AK028268 mRNA. Translation: BAC25851.1.
AK032332 mRNA. Translation: BAC27819.1.
AK049018 mRNA. Translation: BAC33515.1.
AL772385 Genomic DNA. Translation: CAM21532.1.
BC076632 mRNA. Translation: AAH76632.1.
CCDSiCCDS17949.1.
RefSeqiNP_080810.2. NM_026534.2.
UniGeneiMm.404043.
Mm.427021.

Genome annotation databases

EnsembliENSMUST00000029907; ENSMUSP00000029907; ENSMUSG00000028243.
GeneIDi68053.
KEGGimmu:68053.
UCSCiuc008rxj.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUBX2B_MOUSE
AccessioniPrimary (citable) accession number: Q0KL01
Secondary accession number(s): Q8BGY8, Q8CCQ0, Q9CZA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 5, 2017
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families