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Protein

Piezo-type mechanosensitive ion channel component 1

Gene

Piezo1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Piezo-type mechanosensitive ion channel component 1
Alternative name(s):
Membrane protein induced by beta-amyloid treatment
Short name:
Mib
Protein FAM38A
Gene namesi
Name:Piezo1
Synonyms:Fam38a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308822. Piezo1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei27 – 4721HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence analysisAdd
BLAST
Transmembranei426 – 44621HelicalSequence analysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence analysisAdd
BLAST
Transmembranei511 – 53121HelicalSequence analysisAdd
BLAST
Transmembranei568 – 58821HelicalSequence analysisAdd
BLAST
Transmembranei599 – 61921HelicalSequence analysisAdd
BLAST
Transmembranei626 – 64621HelicalSequence analysisAdd
BLAST
Transmembranei678 – 69821HelicalSequence analysisAdd
BLAST
Transmembranei809 – 82921HelicalSequence analysisAdd
BLAST
Transmembranei838 – 85821HelicalSequence analysisAdd
BLAST
Transmembranei912 – 93221HelicalSequence analysisAdd
BLAST
Transmembranei973 – 99321HelicalSequence analysisAdd
BLAST
Transmembranei997 – 101418HelicalSequence analysisAdd
BLAST
Transmembranei1029 – 104921HelicalSequence analysisAdd
BLAST
Transmembranei1146 – 116621HelicalSequence analysisAdd
BLAST
Transmembranei1170 – 119021HelicalSequence analysisAdd
BLAST
Transmembranei1198 – 121821HelicalSequence analysisAdd
BLAST
Transmembranei1223 – 124321HelicalSequence analysisAdd
BLAST
Transmembranei1263 – 128321HelicalSequence analysisAdd
BLAST
Transmembranei1687 – 170721HelicalSequence analysisAdd
BLAST
Transmembranei1721 – 174121HelicalSequence analysisAdd
BLAST
Transmembranei1966 – 198621HelicalSequence analysisAdd
BLAST
Transmembranei2007 – 202721HelicalSequence analysisAdd
BLAST
Transmembranei2036 – 205621HelicalSequence analysisAdd
BLAST
Transmembranei2065 – 208521HelicalSequence analysisAdd
BLAST
Transmembranei2133 – 215321HelicalSequence analysisAdd
BLAST
Transmembranei2181 – 220121HelicalSequence analysisAdd
BLAST
Topological domaini2202 – 2445244ExtracellularBy similarityAdd
BLAST
Transmembranei2446 – 246621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25352535Piezo-type mechanosensitive ion channel component 1PRO_0000305782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis
Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence analysis
Modified residuei749 – 7491PhosphoserineCombined sources
Modified residuei1372 – 13721PhosphoserineCombined sources
Modified residuei1614 – 16141PhosphoserineBy similarity
Modified residuei1618 – 16181PhosphoserineBy similarity
Modified residuei1633 – 16331PhosphoserineCombined sources
Disulfide bondi2425 ↔ 2429By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ0KL00.
PRIDEiQ0KL00.

PTM databases

iPTMnetiQ0KL00.
PhosphoSiteiQ0KL00.

Expressioni

Tissue specificityi

Moderate expression in lung and kidney. Very weak expression in heart, spleen and liver.1 Publication

Inductioni

By APP.1 Publication

Interactioni

Subunit structurei

Homotrimer. Interacts with PKD2. Interacts with STOML3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055134.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1325 – 135632Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 7166Leu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1893. Eukaryota.
ENOG410YVF6. LUCA.
HOVERGENiHBG107901.
InParanoidiQ0KL00.
PhylomeDBiQ0KL00.

Family and domain databases

InterProiIPR027272. Piezo.
IPR031805. Piezo_dom.
IPR031334. Piezo_RRas-bd_dom.
[Graphical view]
PANTHERiPTHR13167. PTHR13167. 1 hit.
PfamiPF15917. PIEZO. 1 hit.
PF12166. Piezo_RRas_bdg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0KL00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPHVLGAGL YWLLLPCTLL AASLLRFNAL SLVYLLFLLL LPWLPGPSRH
60 70 80 90 100
SIPGHTGRLL RALLCLSLLF LVAHVAFQIC LHTMPRLNQL LGQNCNLWAN
110 120 130 140 150
VSQHIGVTRL DLKDIFNTTR LVAPDLGVLV ASSLCLGLCG RLTRKARQSQ
160 170 180 190 200
RTQELEEDDI DAAPAAGLQG APTLATKRRL WLAPRFRITA HWLLVTSGRM
210 220 230 240 250
LVIVLLALAG IAHPSAFSSV YLMVFLAICT WWSCHFPLSS LGFNTLCVMV
260 270 280 290 300
SCFGAGHLVC LYCYQTPFVQ SVLLPGSLWA RLFGLKNFVD IPNCSSPNVL
310 320 330 340 350
VLNTKHAWPI YVSPGILLLL YYTATSLLKL RKGRFSELRK EIPREDEEHE
360 370 380 390 400
LELDQLEPEP QARGTTQGAT PTTTGPDIDN CTVHVLTSQS PVRQRPVRPR
410 420 430 440 450
LAELKEMSPL HGLGHLILDQ SYVCALIAMM VWSIMYHSWL TFVLLLWACL
460 470 480 490 500
IWTVRSRHQL AMLCSPCILL YGLTLCCLRY VWAMELPELP TTLGPVSLHQ
510 520 530 540 550
LGLEHTRYPC LDLGAMLLYL LTFWLLLRQF VKEKLLKKRK APSTLLEVTV
560 570 580 590 600
SDTEPTQTQT LLRSLGELVT GIYVKYWIYV CAGMFIVVSF AGRLVVYKIV
610 620 630 640 650
YMFLFLLCLT LFQVYYTLWR KLLRVFWWLV VAYTMLVLIA VYTFQFQDFP
660 670 680 690 700
TYWRNLTGFT DEQLGDLGLE QFSVSELFSS ILIPGFFLLA CILQLHYFHR
710 720 730 740 750
PFMQLTDLEH VPPPGTRRLR WAHRQDTVSE APLLQHQEEE EVFRDDGQSM
760 770 780 790 800
DGPHQTTQVP EGTASKWGLV ADRLLDLASS FSAVLTRIQV FVRCLLELHV
810 820 830 840 850
FKLVALYTVW VALKEVSVMN LLLVVLWAFA LPYPRFRPMA SCLSTVWTCI
860 870 880 890 900
IIVCKMLYQL KIVNPHEYSS NCTEPFPNNT NLQPLEISQS LLYRGPVDPA
910 920 930 940 950
NWFGVRKGYP NLGYIQNHLQ ILLLLVFEAV VYRRQEHYRR QHQQAPLPAQ
960 970 980 990 1000
ALCADGTRQR LDQDLLSCLK YFINFFFYKF GLEICFLMAV NVIGQRMNFM
1010 1020 1030 1040 1050
VILHGCWLVA ILTRRRREAI ARLWPNYCLF LTLFLLYQYL LCLGMPPALC
1060 1070 1080 1090 1100
IDYPWRWSQA IPMNSALIKW LYLPDFFRAP NSTNLISDFL LLLCASQQWQ
1110 1120 1130 1140 1150
VFSAEQTEEW QRMAGVNTDH LEPLRGEPNP IPNFIHCRSY LDMLKVAVFR
1160 1170 1180 1190 1200
YLFWLVLVVV FVTGATRISI FGLGYLLACF YLLLFGTTLL QKDTRAQLVL
1210 1220 1230 1240 1250
WDCLILYNVT VIISKNMLSL LSCVFVEQMQ SNFCWVIQLF SLVCTVKGYY
1260 1270 1280 1290 1300
DPKEMKTRDR DCLLPVEEAG IIWDSICFFF LLLQRRVFLS HYFLHVSADL
1310 1320 1330 1340 1350
KATALQASRG FALYNAANIK NINFHRQTEE RSLAQLKRQM KRIRAKQEKY
1360 1370 1380 1390 1400
RQSQASRGQL QSTDPQEPGP DSPGGSSPPR TQWWRPWQDH ATVIHSGDYF
1410 1420 1430 1440 1450
LFESDSEEEE EALPEDPRPA AQSAFQMAYQ AWVTNAQTVL RQRREQARRD
1460 1470 1480 1490 1500
RAEQLASGGD LSPEVELVDV PENEMAGHSH VMQRVLSTMQ FLWVLGQATV
1510 1520 1530 1540 1550
DGLTRWLRTF TKDHRTMSDV LCAERYLLTQ ELLRGGEVHR GVLDQLYVSE
1560 1570 1580 1590 1600
DEIALSGPVE NRDGPSTASS GLGAEEPLSS MTDDTGSPLS TGYNTRSGSE
1610 1620 1630 1640 1650
EIITDTGGLQ AGTSLHGSQE LLANARTRMR TASELLLDRR LRIPELEEAE
1660 1670 1680 1690 1700
QFEAQQGRTL RLLRAMYQCV AAHSELLCYF IIILNHMVTA SAASLVLPVL
1710 1720 1730 1740 1750
VFLWAMLTIP RPSKRFWMTA IVFTEVMVVT KYLFQFGFFP WNSYIVLRRY
1760 1770 1780 1790 1800
ENKPYFPPRI LGLEKTDSYI KYDLVQLMAL FFHRSQLLCY GLWDHEEDGV
1810 1820 1830 1840 1850
PKDHCRSSEK DQEAEEESEA KLESQPETGT GHPEEPVLTG TPKDHIQGKG
1860 1870 1880 1890 1900
SVRSKDEIQD PPEDLKPQHR RHISIRFRRR KETQGPKGAA VVEAEHEEGE
1910 1920 1930 1940 1950
EGREAAGRKR LRRPREGLKI REKMKAAGRR LQSFCLSLAQ SFYQPLRRFF
1960 1970 1980 1990 2000
HDILHTKYRA ATDVYALMFL ADIVDIVVII FGFWAFGKHS AATDIASSLS
2010 2020 2030 2040 2050
DDQVPQAFLF MLLVQFGTMV IDRALYLRKT VLGNLAFQVV LVVAIHLWMF
2060 2070 2080 2090 2100
FILPAVTERM FRQNAVAQLW YFVKCIYFAL SAYQIRCGYP TRILGNFLTK
2110 2120 2130 2140 2150
KYNHLNLFLF QGFRLVPFLV ELRAVMDWVW TDTTLSLSNW MCVEDIYANI
2160 2170 2180 2190 2200
FIIKCSRETE KKYPQPKGQK KKKIVKYGMG GLIILFLIAI IWFPLLFMSL
2210 2220 2230 2240 2250
IRSVVGVVNQ PIDVTVTLKL GGYEPLFTMS AQQPSIVPFT PEDYEELSQQ
2260 2270 2280 2290 2300
FDPYPLAMQF ISQYSPEDIV TAQIEGSSGA LWRISPPSRA QMKHELYNGT
2310 2320 2330 2340 2350
ADITLRFTWN FQRDLAKGGS VEYTNEKHTL ELAPNSTARR QLAQLLEGRP
2360 2370 2380 2390 2400
DQSVVIPHLF PKYIRAPNGP EANPVKQLQP DEEEDYLGVR IQLRREQVGT
2410 2420 2430 2440 2450
GTSGEQAGTK ASDFLEWWVI ELQDCQAECN LLPMVIFSDK VSPPSLGFLA
2460 2470 2480 2490 2500
GYGIVGLYVS IVLVVGKFVR GFFSDISHSI MFEELPCVDR ILKLCQDIFL
2510 2520 2530
VRETRELELE EELYAKLIFL YRSPETMIKW TREKE
Length:2,535
Mass (Da):290,315
Last modified:January 11, 2011 - v3
Checksum:i0D02F8B2C2EB65AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113655 Genomic DNA. No translation available.
AABR03113740 Genomic DNA. No translation available.
AABR03114647 Genomic DNA. No translation available.
AB161229 mRNA. Translation: BAF03564.1.
RefSeqiNP_001070668.2. NM_001077200.2.
UniGeneiRn.20892.

Genome annotation databases

GeneIDi361430.
KEGGirno:361430.
UCSCiRGD:1308822. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03113655 Genomic DNA. No translation available.
AABR03113740 Genomic DNA. No translation available.
AABR03114647 Genomic DNA. No translation available.
AB161229 mRNA. Translation: BAF03564.1.
RefSeqiNP_001070668.2. NM_001077200.2.
UniGeneiRn.20892.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055134.

PTM databases

iPTMnetiQ0KL00.
PhosphoSiteiQ0KL00.

Proteomic databases

PaxDbiQ0KL00.
PRIDEiQ0KL00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361430.
KEGGirno:361430.
UCSCiRGD:1308822. rat.

Organism-specific databases

CTDi9780.
RGDi1308822. Piezo1.

Phylogenomic databases

eggNOGiKOG1893. Eukaryota.
ENOG410YVF6. LUCA.
HOVERGENiHBG107901.
InParanoidiQ0KL00.
PhylomeDBiQ0KL00.

Miscellaneous databases

PROiQ0KL00.

Family and domain databases

InterProiIPR027272. Piezo.
IPR031805. Piezo_dom.
IPR031334. Piezo_RRas-bd_dom.
[Graphical view]
PANTHERiPTHR13167. PTHR13167. 1 hit.
PfamiPF15917. PIEZO. 1 hit.
PF12166. Piezo_RRas_bdg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes."
    Satoh K., Hata M., Takahara S., Tsuzaki H., Yokota H., Akatsu H., Yamamoto T., Kosaka K., Yamada T.
    Brain Res. 1108:19-27(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 430-2535, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    Strain: Wistar.
    Tissue: Astrocyte.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-749; SER-1372 AND SER-1633, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPIEZ1_RAT
AccessioniPrimary (citable) accession number: Q0KL00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 11, 2011
Last modified: June 8, 2016
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Piezo comes from the Greek 'piesi' meaning pressure.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.