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Protein

Branched-chain-amino-acid aminotransferase

Gene

ilvE

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on leucine, isoleucine and valine.UniRule annotation

Catalytic activityi

L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (ilvB)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-leucine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. 2-isopropylmalate synthase (leuA2), 2-isopropylmalate synthase (leuA)
  2. 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC3), 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC5), 3-isopropylmalate dehydratase small subunit (leuD5), 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC), 3-isopropylmalate dehydratase small subunit (leuD4)
  3. 3-isopropylmalate dehydrogenase (leuB3)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-leucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-valine from pyruvate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (ilvB)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00047; UER00058
UPA00048; UER00073
UPA00049; UER00062

Names & Taxonomyi

Protein namesi
Recommended name:
Branched-chain-amino-acid aminotransferaseUniRule annotation (EC:2.6.1.42UniRule annotation)
Short name:
BCATUniRule annotation
Gene namesi
Name:ilvEUniRule annotation
Ordered Locus Names:H16_A0561Imported
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)Imported
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000008210 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A0561

Structurei

3D structure databases

ProteinModelPortaliQ0KE61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CM2 Bacteria
COG0115 LUCA
HOGENOMiHOG000276706
KOiK00826
OMAiNFFGITH

Family and domain databases

CDDicd01557 BCAT_beta_family, 1 hit
InterProiView protein in InterPro
IPR001544 Aminotrans_IV
IPR018300 Aminotrans_IV_CS
IPR036038 Aminotransferase-like
IPR005785 B_amino_transI
IPR033939 BCAT_family
PfamiView protein in Pfam
PF01063 Aminotran_4, 1 hit
SUPFAMiSSF56752 SSF56752, 1 hit
TIGRFAMsiTIGR01122 ilvE_I, 1 hit
PROSITEiView protein in PROSITE
PS00770 AA_TRANSFER_CLASS_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q0KE61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMADRDGKI WMDGKLIEWR DAKIHVLTHT LHYGMGVFEG VRAYKTPEGT
60 70 80 90 100
AIFRLKEHTR RLFNSAKIFQ MVMPFDEATL EAAQREVVRA NKLESCYIRP
110 120 130 140 150
IVWVGDEKLG VSAKGNTIHV AIAAWPWGAY LGEEGMERGI RVKTSSFTRH
160 170 180 190 200
HVNVSLVRAK ASGYYINSIL ANQEATGLGY DEALLLDTEG YVSEGSGENV
210 220 230 240 250
FIVRNGVIYT PDLASCLDGI TRDATLTIAR DLGIEVREKR ITRDEMYCAD
260 270 280 290 300
EAFFTGTAAE VTPIRELDDR VIGEGRRGPV TKQIQDAFFA AVGGTNEKYK

KWLTLV
Length:306
Mass (Da):34,216
Last modified:October 3, 2006 - v1
Checksum:i3D3B6925963B9569
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA Translation: CAJ91710.1
RefSeqiWP_010812204.1, NC_008313.1

Genome annotation databases

EnsemblBacteriaiCAJ91710; CAJ91710; H16_A0561
KEGGireh:H16_A0561
PATRICifig|381666.6.peg.927

Similar proteinsi

Entry informationi

Entry nameiQ0KE61_CUPNH
AccessioniPrimary (citable) accession number: Q0KE61
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health