ID   Q0KDM8_CUPNH            Unreviewed;       478 AA.
AC   Q0KDM8;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   SubName: Full=NAD-dependent aldehyde dehydrogenase {ECO:0000313|EMBL:CAJ91893.1};
DE            EC=1.2.1.3 {ECO:0000313|EMBL:CAJ91893.1};
GN   OrderedLocusNames=H16_A0745 {ECO:0000313|EMBL:CAJ91893.1};
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ91893.1, ECO:0000313|Proteomes:UP000008210};
RN   [1] {ECO:0000313|EMBL:CAJ91893.1, ECO:0000313|Proteomes:UP000008210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC   337 {ECO:0000313|Proteomes:UP000008210};
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM260479; CAJ91893.1; -; Genomic_DNA.
DR   RefSeq; WP_010813007.1; NZ_CP039287.1.
DR   AlphaFoldDB; Q0KDM8; -.
DR   STRING; 381666.H16_A0745; -.
DR   GeneID; 57642842; -.
DR   KEGG; reh:H16_A0745; -.
DR   PATRIC; fig|381666.6.peg.1116; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_0_2_4; -.
DR   OrthoDB; 6187633at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   CDD; cd07109; ALDH_AAS00426; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008210}.
FT   DOMAIN          18..473
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        247
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   478 AA;  50762 MW;  4C0AAB9E59FB884E CRC64;
     MHAQHFVANR LIAPDNGLRI KVFDPSNGEP FAEIARGNAT DINVAVHAAR QAAEGAWGQM
     APAERVRLLN RVAVALIAHE DELAALEARD TGKPLRQARA DARAVARYFE FYAGAVDKLH
     GQTIPYNPGY TVLTVREPHG VTGHIIPWNY PLQIFGRSVG AALATGNACV VKPAEDACLS
     LLRVAEIAAD AGLPEGALNI ITGYGHEAGA ALARHPGINH ISFTGSPQTG KQVAQLAAEN
     HVPVTLELGG KSPQIVFADA DLDTLVPVVV NGIVQNAGQT CSAGSRLLVE RPVYDALLDR
     LASVFESLRV GPSELDLECG PLISRKQQQR VWDFVSDAQH AGVAVMAQGQ IVADAPEAGY
     YQVPMLFRDV PPAHRLAQEE VFGPLLAAMP FDTEAEAIAL ANGTPYGLVA GVWTRDGGRQ
     LRLAHKLRAG QVFINNYGAG GGVELPFGGT GQSGYGREKG FEALYGFTTL KTIAIQHG
//