ID   HLDD_RALEH              Reviewed;         331 AA.
AC   Q0KDH0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase;
DE            EC=5.1.3.20;
DE   AltName: Full=ADP-L-glycero-beta-D-manno-heptose-6-epimerase;
DE            Short=ADP-glyceromanno-heptose 6-epimerase;
DE            Short=ADP-hep 6-epimerase;
DE            Short=AGME;
GN   Name=hldD; OrderedLocusNames=H16_A0804;
OS   Ralstonia eutropha (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
OS   (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier
OS   337)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H.,
RA   Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E.,
RA   Strittmatter A., Voss I., Gottschalk G., Steinbuechel A.,
RA   Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium
RT   Ralstonia eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Catalyzes the interconversion between ADP-D-glycero-
CC       beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an
CC       epimerization at carbon 6 of the heptose (By similarity).
CC   -!- CATALYTIC ACTIVITY: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-
CC       D-manno-heptose.
CC   -!- COFACTOR: Binds 1 NADP(+) per subunit (By similarity).
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-
CC       manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose
CC       from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
CC   -!- SUBUNIT: Homopentamer (By similarity).
CC   -!- DOMAIN: Contains a large N-terminal NADP-binding domain, and a
CC       smaller C-terminal substrate-binding domain (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family. HldD subfamily.
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DR   EMBL; AM260479; CAJ91951.1; -; Genomic_DNA.
DR   RefSeq; YP_725319.1; -.
DR   GeneID; 4250456; -.
DR   GenomeReviews; AM260479_GR; H16_A0804.
DR   KEGG; reh:H16_A0804; -.
DR   HOGENOM; Q0KDH0; -.
DR   OMA; Q0KDH0; FGPNEYH.
DR   GO; GO:0008712; F:ADP-glyceromanno-heptose 6-epimerase activity; IEA:HAMAP.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:HAMAP.
DR   GO; GO:0044237; P:cellular metabolic process; IEA:InterPro.
DR   HAMAP; MF_01601; -; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR011912; Heptose_epim.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR10366:SF29; Heptose_epim; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   TIGRFAMs; TIGR02197; heptose_epim; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Isomerase; NADP.
FT   CHAIN         1    331       ADP-L-glycero-D-manno-heptose-6-
FT                                epimerase.
FT                                /FTId=PRO_1000069365.
FT   NP_BIND      11     12       NADP (By similarity).
FT   NP_BIND      32     33       NADP (By similarity).
FT   NP_BIND      75     79       NADP (By similarity).
FT   REGION      200    203       Substrate binding (By similarity).
FT   ACT_SITE    139    139       Proton acceptor (By similarity).
FT   ACT_SITE    177    177       Proton acceptor (By similarity).
FT   BINDING      39     39       NADP (By similarity).
FT   BINDING      54     54       NADP (By similarity).
FT   BINDING      92     92       NADP (By similarity).
FT   BINDING     143    143       NADP (By similarity).
FT   BINDING     168    168       Substrate (By similarity).
FT   BINDING     169    169       NADP; via amide nitrogen (By similarity).
FT   BINDING     177    177       NADP (By similarity).
FT   BINDING     179    179       Substrate; via carbonyl oxygen (By
FT                                similarity).
FT   BINDING     186    186       Substrate (By similarity).
FT   BINDING     213    213       Substrate (By similarity).
FT   BINDING     292    292       Substrate (By similarity).
SQ   SEQUENCE   331 AA;  37428 MW;  4ED4171C4F798A5E CRC64;
     MTIIVTGAAG FIGSNLVKGL NDRGETNVIA VDNLTRADKF HNLVDCEISD YLDKQDFLAR
     FARGEFGKVR AVFHEGACSD TMETDGRYMM ENNYRYTLSL MESCLEQGTQ FLYASSAATY
     GASQVFREDR EFERPLNVYG YSKFLFDQIV RRRLPSALSQ IVGFRYFNVY GPRETHKGRM
     ASVAFHNFNQ FRADGTVKLF GEYGGYAPGM QSRDFISVED VVKVNLHFFD HPDKSGIFNL
     GTGRAQPFND IAATVVNTLR EAEGKPRLSL DELVQEGLLE YVKFPDALRG KYQCFTQSDV
     SKLRSAGYSE PFLSVEEGVA RYCRWLIERA G
//