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Q0KA59 (TYPH1_CUPNH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative thymidine phosphorylase 1

EC=2.4.2.4
Alternative name(s):
TdRPase 1
Gene names
Ordered Locus Names:H16_A2012
OrganismCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) [Complete proteome] [HAMAP]
Taxonomic identifier381666 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 520520Putative thymidine phosphorylase 1 HAMAP-Rule MF_00703
PRO_0000314708

Sequences

Sequence LengthMass (Da)Tools
Q0KA59 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 4DA9BFC23FD5A27E

FASTA52054,581
        10         20         30         40         50         60 
MNDASSDPGI PGRPGDVVAA AAPREVGALV FRPLEIDTWQ EHVIYMHPDC PVCRAEGFSA 

        70         80         90        100        110        120 
QARVRVQIGD RSLIATLTLL GAPLLNTGEA SLSLSAARTL SARAGDVVHV THAPALESVR 

       130        140        150        160        170        180 
ALRAKIYGCH LDSVQLDGII GDISAGRYAD VHIAAFLTAC ADGRMSLRET VDLTRAMVRS 

       190        200        210        220        230        240 
GQRLNWDREV VADKHCVGGL PGNRTTPVVV AIAAAAGLLL PKTSSRAITS PAGTADTMEA 

       250        260        270        280        290        300 
LTRVTLDSTE LRRVVEQVGA ALVWGGALSL SPADDVLIRV ERALDIDSDA QLVASILSKK 

       310        320        330        340        350        360 
IAAGSTHVLI DVPVGPTAKI REDSDLARLD LAMTKVADAF GLKLRILRTD GSQPVGRGVG 

       370        380        390        400        410        420 
PALEALDVLA VLQCQPTAPA DLRERSLLLA GELLEFCGAI PPGQGRLLAG SLLDSGAAWA 

       430        440        450        460        470        480 
RFQAICEAQG GLRTPGQAVF RRDVVAARSG IVTSVDNRHV ARTAKLAGAP RRQVAGLELH 

       490        500        510        520 
VRAGDEVVAG APLCTLHAQA SGELEYAFSY ALAHDPFRIE 

« Hide

References

[1]"Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16."
Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.
Nat. Biotechnol. 24:1257-1262(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM260479 Genomic DNA. Translation: CAJ93112.1.
RefSeqYP_726480.1. NC_008313.1.

3D structure databases

ProteinModelPortalQ0KA59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING381666.H16_A2012.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ93112; CAJ93112; H16_A2012.
GeneID4248759.
KEGGreh:H16_A2012.
PATRIC35233535. VBIRalEut6770_2418.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000252767.
KOK00758.
OMAMNDASSD.
OrthoDBEOG61ZTGG.

Enzyme and pathway databases

BioCycCNEC381666:GJUJ-1980-MONOMER.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_00703. Thymid_phosp_2.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH1_CUPNH
AccessionPrimary (citable) accession number: Q0KA59
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families