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Protein

Putative thymidine phosphorylase 1

Gene

H16_A2012

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. thymidine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-1980-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thymidine phosphorylase 1UniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPase 1UniRule annotation
Gene namesi
Ordered Locus Names:H16_A2012
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Putative thymidine phosphorylase 1PRO_0000314708Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A2012.

Structurei

3D structure databases

ProteinModelPortaliQ0KA59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiHAKVGYR.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0KA59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNDASSDPGI PGRPGDVVAA AAPREVGALV FRPLEIDTWQ EHVIYMHPDC
60 70 80 90 100
PVCRAEGFSA QARVRVQIGD RSLIATLTLL GAPLLNTGEA SLSLSAARTL
110 120 130 140 150
SARAGDVVHV THAPALESVR ALRAKIYGCH LDSVQLDGII GDISAGRYAD
160 170 180 190 200
VHIAAFLTAC ADGRMSLRET VDLTRAMVRS GQRLNWDREV VADKHCVGGL
210 220 230 240 250
PGNRTTPVVV AIAAAAGLLL PKTSSRAITS PAGTADTMEA LTRVTLDSTE
260 270 280 290 300
LRRVVEQVGA ALVWGGALSL SPADDVLIRV ERALDIDSDA QLVASILSKK
310 320 330 340 350
IAAGSTHVLI DVPVGPTAKI REDSDLARLD LAMTKVADAF GLKLRILRTD
360 370 380 390 400
GSQPVGRGVG PALEALDVLA VLQCQPTAPA DLRERSLLLA GELLEFCGAI
410 420 430 440 450
PPGQGRLLAG SLLDSGAAWA RFQAICEAQG GLRTPGQAVF RRDVVAARSG
460 470 480 490 500
IVTSVDNRHV ARTAKLAGAP RRQVAGLELH VRAGDEVVAG APLCTLHAQA
510 520
SGELEYAFSY ALAHDPFRIE
Length:520
Mass (Da):54,581
Last modified:October 3, 2006 - v1
Checksum:i4DA9BFC23FD5A27E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93112.1.
RefSeqiYP_726480.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93112; CAJ93112; H16_A2012.
GeneIDi4248759.
KEGGireh:H16_A2012.
PATRICi35233535. VBIRalEut6770_2418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93112.1.
RefSeqiYP_726480.1. NC_008313.1.

3D structure databases

ProteinModelPortaliQ0KA59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381666.H16_A2012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ93112; CAJ93112; H16_A2012.
GeneIDi4248759.
KEGGireh:H16_A2012.
PATRICi35233535. VBIRalEut6770_2418.

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiHAKVGYR.
OrthoDBiEOG61ZTGG.

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-1980-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiTYPH1_CUPNH
AccessioniPrimary (citable) accession number: Q0KA59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: February 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.