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Q0KA59

- TYPH1_CUPNH

UniProt

Q0KA59 - TYPH1_CUPNH

Protein

Putative thymidine phosphorylase 1

Gene

H16_A2012

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. thymidine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciCNEC381666:GJUJ-1980-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative thymidine phosphorylase 1UniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPase 1UniRule annotation
    Gene namesi
    Ordered Locus Names:H16_A2012
    OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
    Taxonomic identifieri381666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000008210: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Putative thymidine phosphorylase 1PRO_0000314708Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381666.H16_A2012.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0KA59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiMNDASSD.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0KA59-1 [UniParc]FASTAAdd to Basket

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    MNDASSDPGI PGRPGDVVAA AAPREVGALV FRPLEIDTWQ EHVIYMHPDC    50
    PVCRAEGFSA QARVRVQIGD RSLIATLTLL GAPLLNTGEA SLSLSAARTL 100
    SARAGDVVHV THAPALESVR ALRAKIYGCH LDSVQLDGII GDISAGRYAD 150
    VHIAAFLTAC ADGRMSLRET VDLTRAMVRS GQRLNWDREV VADKHCVGGL 200
    PGNRTTPVVV AIAAAAGLLL PKTSSRAITS PAGTADTMEA LTRVTLDSTE 250
    LRRVVEQVGA ALVWGGALSL SPADDVLIRV ERALDIDSDA QLVASILSKK 300
    IAAGSTHVLI DVPVGPTAKI REDSDLARLD LAMTKVADAF GLKLRILRTD 350
    GSQPVGRGVG PALEALDVLA VLQCQPTAPA DLRERSLLLA GELLEFCGAI 400
    PPGQGRLLAG SLLDSGAAWA RFQAICEAQG GLRTPGQAVF RRDVVAARSG 450
    IVTSVDNRHV ARTAKLAGAP RRQVAGLELH VRAGDEVVAG APLCTLHAQA 500
    SGELEYAFSY ALAHDPFRIE 520
    Length:520
    Mass (Da):54,581
    Last modified:October 3, 2006 - v1
    Checksum:i4DA9BFC23FD5A27E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260479 Genomic DNA. Translation: CAJ93112.1.
    RefSeqiWP_011615453.1. NC_008313.1.
    YP_726480.1. NC_008313.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ93112; CAJ93112; H16_A2012.
    GeneIDi4248759.
    KEGGireh:H16_A2012.
    PATRICi35233535. VBIRalEut6770_2418.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260479 Genomic DNA. Translation: CAJ93112.1 .
    RefSeqi WP_011615453.1. NC_008313.1.
    YP_726480.1. NC_008313.1.

    3D structure databases

    ProteinModelPortali Q0KA59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381666.H16_A2012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ93112 ; CAJ93112 ; H16_A2012 .
    GeneIDi 4248759.
    KEGGi reh:H16_A2012.
    PATRICi 35233535. VBIRalEut6770_2418.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi MNDASSD.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    BioCyci CNEC381666:GJUJ-1980-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

    Entry informationi

    Entry nameiTYPH1_CUPNH
    AccessioniPrimary (citable) accession number: Q0KA59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3