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Q0K9B9

- IF2_CUPNH

UniProt

Q0K9B9 - IF2_CUPNH

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi471 – 4788GTPUniRule annotation
    Nucleotide bindingi517 – 5215GTPUniRule annotation
    Nucleotide bindingi571 – 5744GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCNEC381666:GJUJ-2274-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:H16_A2306
    OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
    Taxonomic identifieri381666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000008210: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Translation initiation factor IF-2PRO_1000008310Add
    BLAST

    Proteomic databases

    PRIDEiQ0K9B9.

    Interactioni

    Protein-protein interaction databases

    STRINGi381666.H16_A2306.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0K9B9.
    SMRiQ0K9B9. Positions 865-960.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini462 – 631170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni471 – 4788G1By similarity
    Regioni496 – 5005G2By similarity
    Regioni517 – 5204G3By similarity
    Regioni571 – 5744G4By similarity
    Regioni607 – 6093G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    KOiK02519.
    OMAiDATGKTR.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0K9B9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTTVAQLA AELSRSAAAL LEQLQAAGVG KATPEDIITE SDKTRLLDYL    50
    KRSHGQADDS SRKKITLTKR ETSEIRQSDG TGKTRTVQVE VRKKRVLIKR 100
    DEAAPDAQAD AVEAQAPVVD AVEEARRDEE ERQQAELLAR QEAEAKAARE 150
    AAEREEAERR ARQEALEAEQ RRQAELAARK AEEEAAASRA VTEANEDSSR 200
    KKAEDEKARV TAERAEAQKA ADEAKAAADK ARAEQEVAAR KRREAAEAEA 250
    RAIQQMLNAP PRVLKAPSER KAEEKKAEQT GTLHKPVKPA GATTEAKKDE 300
    KKPATTTTTT ATADKKGKVV KAGWQDDSSR KKGSGLKTRG DTSGGVGGWR 350
    GGPRGRGGRQ QQHDDSRSSF QAPTEPVVRE VHVPETVSVA DLAHKMAVKA 400
    SEVIKQMMKL GQMVTINQVL DQETAMIVVE EMGHKAYAAK LDDPEALLVV 450
    GGEEHTDAEL LPRPPVVTVM GHVDHGKTSL LDYIRRTKVA AGEAGGITQH 500
    IGAYHVETDR GVITFLDTPG HEAFTAMRAR GAKATDIVIL VVAADDGVMP 550
    QTKEAIAHAK AAGVPIVVAI NKIDKPDANP DRVKQELVAE QVVPEEYGGD 600
    SPFVPVSAKM GTGVEDLLEQ VLLQAEVLEL TAPVDAPAKG LVVEAQLDKG 650
    KGPIATILVS SGTLKRGDVV LAGSAYGRVR AMLDENGKPT KEAGPSIPVE 700
    IQGLSEVPAA GEEVLVLPDE RKAREIALFR QGKFRDVKLA KQQAAKLENM 750
    LEQMAEGEVQ TLPLIVKADV QGSQEALVQS LQKLSTAEVR VQIVHGGVGG 800
    ISESDVNLAT ASKAVIIGFN VRADAGARKL AEHNGIDIRY YNIIYDAVDE 850
    IKAAMSGMLA PEKRETTIGQ VEVRQVFRVP KIGAVAGCMV TDGLVKRNSL 900
    VRVLRNNVVI HDGELDSLKR FKDDVKEVKQ GFECGLSIKN FNDVQEGDQL 950
    EVYEITEVAR TL 962
    Length:962
    Mass (Da):103,710
    Last modified:October 3, 2006 - v1
    Checksum:iAB8F163CF73F5741
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260479 Genomic DNA. Translation: CAJ93402.1.
    RefSeqiYP_726770.1. NC_008313.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ93402; CAJ93402; H16_A2306.
    GeneIDi4250192.
    KEGGireh:H16_A2306.
    PATRICi35234125. VBIRalEut6770_2709.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260479 Genomic DNA. Translation: CAJ93402.1 .
    RefSeqi YP_726770.1. NC_008313.1.

    3D structure databases

    ProteinModelPortali Q0K9B9.
    SMRi Q0K9B9. Positions 865-960.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381666.H16_A2306.

    Proteomic databases

    PRIDEi Q0K9B9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ93402 ; CAJ93402 ; H16_A2306 .
    GeneIDi 4250192.
    KEGGi reh:H16_A2306.
    PATRICi 35234125. VBIRalEut6770_2709.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    KOi K02519.
    OMAi DATGKTR.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci CNEC381666:GJUJ-2274-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

    Entry informationi

    Entry nameiIF2_CUPNH
    AccessioniPrimary (citable) accession number: Q0K9B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3