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Q0K9B9

- IF2_CUPNH

UniProt

Q0K9B9 - IF2_CUPNH

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi471 – 4788GTPUniRule annotation
Nucleotide bindingi517 – 5215GTPUniRule annotation
Nucleotide bindingi571 – 5744GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-2274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:H16_A2306
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Translation initiation factor IF-2PRO_1000008310Add
BLAST

Proteomic databases

PRIDEiQ0K9B9.

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A2306.

Structurei

3D structure databases

ProteinModelPortaliQ0K9B9.
SMRiQ0K9B9. Positions 865-960.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini462 – 631170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni471 – 4788G1By similarity
Regioni496 – 5005G2By similarity
Regioni517 – 5204G3By similarity
Regioni571 – 5744G4By similarity
Regioni607 – 6093G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiDATGKTR.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K9B9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASTTVAQLA AELSRSAAAL LEQLQAAGVG KATPEDIITE SDKTRLLDYL
60 70 80 90 100
KRSHGQADDS SRKKITLTKR ETSEIRQSDG TGKTRTVQVE VRKKRVLIKR
110 120 130 140 150
DEAAPDAQAD AVEAQAPVVD AVEEARRDEE ERQQAELLAR QEAEAKAARE
160 170 180 190 200
AAEREEAERR ARQEALEAEQ RRQAELAARK AEEEAAASRA VTEANEDSSR
210 220 230 240 250
KKAEDEKARV TAERAEAQKA ADEAKAAADK ARAEQEVAAR KRREAAEAEA
260 270 280 290 300
RAIQQMLNAP PRVLKAPSER KAEEKKAEQT GTLHKPVKPA GATTEAKKDE
310 320 330 340 350
KKPATTTTTT ATADKKGKVV KAGWQDDSSR KKGSGLKTRG DTSGGVGGWR
360 370 380 390 400
GGPRGRGGRQ QQHDDSRSSF QAPTEPVVRE VHVPETVSVA DLAHKMAVKA
410 420 430 440 450
SEVIKQMMKL GQMVTINQVL DQETAMIVVE EMGHKAYAAK LDDPEALLVV
460 470 480 490 500
GGEEHTDAEL LPRPPVVTVM GHVDHGKTSL LDYIRRTKVA AGEAGGITQH
510 520 530 540 550
IGAYHVETDR GVITFLDTPG HEAFTAMRAR GAKATDIVIL VVAADDGVMP
560 570 580 590 600
QTKEAIAHAK AAGVPIVVAI NKIDKPDANP DRVKQELVAE QVVPEEYGGD
610 620 630 640 650
SPFVPVSAKM GTGVEDLLEQ VLLQAEVLEL TAPVDAPAKG LVVEAQLDKG
660 670 680 690 700
KGPIATILVS SGTLKRGDVV LAGSAYGRVR AMLDENGKPT KEAGPSIPVE
710 720 730 740 750
IQGLSEVPAA GEEVLVLPDE RKAREIALFR QGKFRDVKLA KQQAAKLENM
760 770 780 790 800
LEQMAEGEVQ TLPLIVKADV QGSQEALVQS LQKLSTAEVR VQIVHGGVGG
810 820 830 840 850
ISESDVNLAT ASKAVIIGFN VRADAGARKL AEHNGIDIRY YNIIYDAVDE
860 870 880 890 900
IKAAMSGMLA PEKRETTIGQ VEVRQVFRVP KIGAVAGCMV TDGLVKRNSL
910 920 930 940 950
VRVLRNNVVI HDGELDSLKR FKDDVKEVKQ GFECGLSIKN FNDVQEGDQL
960
EVYEITEVAR TL
Length:962
Mass (Da):103,710
Last modified:October 3, 2006 - v1
Checksum:iAB8F163CF73F5741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93402.1.
RefSeqiYP_726770.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93402; CAJ93402; H16_A2306.
GeneIDi4250192.
KEGGireh:H16_A2306.
PATRICi35234125. VBIRalEut6770_2709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93402.1 .
RefSeqi YP_726770.1. NC_008313.1.

3D structure databases

ProteinModelPortali Q0K9B9.
SMRi Q0K9B9. Positions 865-960.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_A2306.

Proteomic databases

PRIDEi Q0K9B9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ93402 ; CAJ93402 ; H16_A2306 .
GeneIDi 4250192.
KEGGi reh:H16_A2306.
PATRICi 35234125. VBIRalEut6770_2709.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi DATGKTR.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci CNEC381666:GJUJ-2274-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiIF2_CUPNH
AccessioniPrimary (citable) accession number: Q0K9B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3