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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi471 – 478GTPUniRule annotation8
Nucleotide bindingi517 – 521GTPUniRule annotation5
Nucleotide bindingi571 – 574GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:H16_A2306
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000008210 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000083101 – 962Translation initiation factor IF-2Add BLAST962

Proteomic databases

PRIDEiQ0K9B9.

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A2306.

Structurei

3D structure databases

ProteinModelPortaliQ0K9B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini462 – 631tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni471 – 478G1By similarity8
Regioni496 – 500G2By similarity5
Regioni517 – 520G3By similarity4
Regioni571 – 574G4By similarity4
Regioni607 – 609G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076907.
KOiK02519.
OMAiEVIKQMM.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K9B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTTVAQLA AELSRSAAAL LEQLQAAGVG KATPEDIITE SDKTRLLDYL
60 70 80 90 100
KRSHGQADDS SRKKITLTKR ETSEIRQSDG TGKTRTVQVE VRKKRVLIKR
110 120 130 140 150
DEAAPDAQAD AVEAQAPVVD AVEEARRDEE ERQQAELLAR QEAEAKAARE
160 170 180 190 200
AAEREEAERR ARQEALEAEQ RRQAELAARK AEEEAAASRA VTEANEDSSR
210 220 230 240 250
KKAEDEKARV TAERAEAQKA ADEAKAAADK ARAEQEVAAR KRREAAEAEA
260 270 280 290 300
RAIQQMLNAP PRVLKAPSER KAEEKKAEQT GTLHKPVKPA GATTEAKKDE
310 320 330 340 350
KKPATTTTTT ATADKKGKVV KAGWQDDSSR KKGSGLKTRG DTSGGVGGWR
360 370 380 390 400
GGPRGRGGRQ QQHDDSRSSF QAPTEPVVRE VHVPETVSVA DLAHKMAVKA
410 420 430 440 450
SEVIKQMMKL GQMVTINQVL DQETAMIVVE EMGHKAYAAK LDDPEALLVV
460 470 480 490 500
GGEEHTDAEL LPRPPVVTVM GHVDHGKTSL LDYIRRTKVA AGEAGGITQH
510 520 530 540 550
IGAYHVETDR GVITFLDTPG HEAFTAMRAR GAKATDIVIL VVAADDGVMP
560 570 580 590 600
QTKEAIAHAK AAGVPIVVAI NKIDKPDANP DRVKQELVAE QVVPEEYGGD
610 620 630 640 650
SPFVPVSAKM GTGVEDLLEQ VLLQAEVLEL TAPVDAPAKG LVVEAQLDKG
660 670 680 690 700
KGPIATILVS SGTLKRGDVV LAGSAYGRVR AMLDENGKPT KEAGPSIPVE
710 720 730 740 750
IQGLSEVPAA GEEVLVLPDE RKAREIALFR QGKFRDVKLA KQQAAKLENM
760 770 780 790 800
LEQMAEGEVQ TLPLIVKADV QGSQEALVQS LQKLSTAEVR VQIVHGGVGG
810 820 830 840 850
ISESDVNLAT ASKAVIIGFN VRADAGARKL AEHNGIDIRY YNIIYDAVDE
860 870 880 890 900
IKAAMSGMLA PEKRETTIGQ VEVRQVFRVP KIGAVAGCMV TDGLVKRNSL
910 920 930 940 950
VRVLRNNVVI HDGELDSLKR FKDDVKEVKQ GFECGLSIKN FNDVQEGDQL
960
EVYEITEVAR TL
Length:962
Mass (Da):103,710
Last modified:October 3, 2006 - v1
Checksum:iAB8F163CF73F5741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93402.1.
RefSeqiWP_010809483.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93402; CAJ93402; H16_A2306.
GeneIDi4250192.
KEGGireh:H16_A2306.
PATRICi35234125. VBIRalEut6770_2709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93402.1.
RefSeqiWP_010809483.1. NC_008313.1.

3D structure databases

ProteinModelPortaliQ0K9B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381666.H16_A2306.

Proteomic databases

PRIDEiQ0K9B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ93402; CAJ93402; H16_A2306.
GeneIDi4250192.
KEGGireh:H16_A2306.
PATRICi35234125. VBIRalEut6770_2709.

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076907.
KOiK02519.
OMAiEVIKQMM.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_CUPNH
AccessioniPrimary (citable) accession number: Q0K9B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.