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Q0K9B9

- IF2_CUPNH

UniProt

Q0K9B9 - IF2_CUPNH

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Protein
Translation initiation factor IF-2
Gene
infB, H16_A2306
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi471 – 4788GTP By similarity
Nucleotide bindingi517 – 5215GTP By similarity
Nucleotide bindingi571 – 5744GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-2274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:H16_A2306
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Translation initiation factor IF-2UniRule annotation
PRO_1000008310Add
BLAST

Proteomic databases

PRIDEiQ0K9B9.

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A2306.

Structurei

3D structure databases

ProteinModelPortaliQ0K9B9.
SMRiQ0K9B9. Positions 865-960.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini462 – 631170tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni471 – 4788G1 By similarity
Regioni496 – 5005G2 By similarity
Regioni517 – 5204G3 By similarity
Regioni571 – 5744G4 By similarity
Regioni607 – 6093G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiDATGKTR.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K9B9-1 [UniParc]FASTAAdd to Basket

« Hide

MASTTVAQLA AELSRSAAAL LEQLQAAGVG KATPEDIITE SDKTRLLDYL    50
KRSHGQADDS SRKKITLTKR ETSEIRQSDG TGKTRTVQVE VRKKRVLIKR 100
DEAAPDAQAD AVEAQAPVVD AVEEARRDEE ERQQAELLAR QEAEAKAARE 150
AAEREEAERR ARQEALEAEQ RRQAELAARK AEEEAAASRA VTEANEDSSR 200
KKAEDEKARV TAERAEAQKA ADEAKAAADK ARAEQEVAAR KRREAAEAEA 250
RAIQQMLNAP PRVLKAPSER KAEEKKAEQT GTLHKPVKPA GATTEAKKDE 300
KKPATTTTTT ATADKKGKVV KAGWQDDSSR KKGSGLKTRG DTSGGVGGWR 350
GGPRGRGGRQ QQHDDSRSSF QAPTEPVVRE VHVPETVSVA DLAHKMAVKA 400
SEVIKQMMKL GQMVTINQVL DQETAMIVVE EMGHKAYAAK LDDPEALLVV 450
GGEEHTDAEL LPRPPVVTVM GHVDHGKTSL LDYIRRTKVA AGEAGGITQH 500
IGAYHVETDR GVITFLDTPG HEAFTAMRAR GAKATDIVIL VVAADDGVMP 550
QTKEAIAHAK AAGVPIVVAI NKIDKPDANP DRVKQELVAE QVVPEEYGGD 600
SPFVPVSAKM GTGVEDLLEQ VLLQAEVLEL TAPVDAPAKG LVVEAQLDKG 650
KGPIATILVS SGTLKRGDVV LAGSAYGRVR AMLDENGKPT KEAGPSIPVE 700
IQGLSEVPAA GEEVLVLPDE RKAREIALFR QGKFRDVKLA KQQAAKLENM 750
LEQMAEGEVQ TLPLIVKADV QGSQEALVQS LQKLSTAEVR VQIVHGGVGG 800
ISESDVNLAT ASKAVIIGFN VRADAGARKL AEHNGIDIRY YNIIYDAVDE 850
IKAAMSGMLA PEKRETTIGQ VEVRQVFRVP KIGAVAGCMV TDGLVKRNSL 900
VRVLRNNVVI HDGELDSLKR FKDDVKEVKQ GFECGLSIKN FNDVQEGDQL 950
EVYEITEVAR TL 962
Length:962
Mass (Da):103,710
Last modified:October 3, 2006 - v1
Checksum:iAB8F163CF73F5741
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260479 Genomic DNA. Translation: CAJ93402.1.
RefSeqiYP_726770.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93402; CAJ93402; H16_A2306.
GeneIDi4250192.
KEGGireh:H16_A2306.
PATRICi35234125. VBIRalEut6770_2709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260479 Genomic DNA. Translation: CAJ93402.1 .
RefSeqi YP_726770.1. NC_008313.1.

3D structure databases

ProteinModelPortali Q0K9B9.
SMRi Q0K9B9. Positions 865-960.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_A2306.

Proteomic databases

PRIDEi Q0K9B9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ93402 ; CAJ93402 ; H16_A2306 .
GeneIDi 4250192.
KEGGi reh:H16_A2306.
PATRICi 35234125. VBIRalEut6770_2709.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi DATGKTR.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci CNEC381666:GJUJ-2274-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiIF2_CUPNH
AccessioniPrimary (citable) accession number: Q0K9B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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