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Q0K8J9 (PNCB_CUPNH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:H16_A2589
OrganismCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) [Complete proteome] [HAMAP]
Taxonomic identifier381666 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000025009

Sequences

Sequence LengthMass (Da)Tools
Q0K8J9 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 0F32061160CA3A25

FASTA39245,180
        10         20         30         40         50         60 
MIIPSLLDTD LYKFTMMQVV LHQFPQAQVE YRFKCRNAGV DLTPYIDEIR AEVAHLCQLR 

        70         80         90        100        110        120 
FTDDELAYLR GLRFIKSDFV DFLGLFHLNE KYVSVRPSPQ GNGEIEISII GPWLHTILFE 

       130        140        150        160        170        180 
VPVLAIVNEV YFRRTQPRPD LAEGRRRLDQ KLALLKTPEL ADCVIADYGT RRRFSREWQE 

       190        200        210        220        230        240 
EVLLTMRRLL GPQLAGTSNV HFARLHNMVP LGTMAHEYLQ ACQALGPRLR DSQVYALERW 

       250        260        270        280        290        300 
AREYRGDLGI ALSDTYGFDA FLRDFDLYFC KLFDGVRHDS GDPMLWGERM VAHYAANRVD 

       310        320        330        340        350        360 
PRTKTLIFSD SLDIPRVIEL YERFHGRCRL AFGVGTNLTN DLGYTPLQIV IKMVRCNGQP 

       370        380        390 
VAKLSDTPEK TMCDDPGYLS YLRQVYSVQP AA 

« Hide

References

[1]"Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16."
Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.
Nat. Biotechnol. 24:1257-1262(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM260479 Genomic DNA. Translation: CAJ93672.1.
RefSeqYP_727040.1. NC_008313.1.

3D structure databases

ProteinModelPortalQ0K8J9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING381666.H16_A2589.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ93672; CAJ93672; H16_A2589.
GeneID4250031.
KEGGreh:H16_A2589.
PATRIC35234681. VBIRalEut6770_2975.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMASIVCKVI.
OrthoDBEOG6X10XB.

Enzyme and pathway databases

BioCycCNEC381666:GJUJ-2556-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_CUPNH
AccessionPrimary (citable) accession number: Q0K8J9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways