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Q0K8J9

- PNCB_CUPNH

UniProt

Q0K8J9 - PNCB_CUPNH

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-2556-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:H16_A2589
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Nicotinate phosphoribosyltransferasePRO_1000025009Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A2589.

Structurei

3D structure databases

ProteinModelPortaliQ0K8J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiSIVCKVI.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0K8J9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIPSLLDTD LYKFTMMQVV LHQFPQAQVE YRFKCRNAGV DLTPYIDEIR
60 70 80 90 100
AEVAHLCQLR FTDDELAYLR GLRFIKSDFV DFLGLFHLNE KYVSVRPSPQ
110 120 130 140 150
GNGEIEISII GPWLHTILFE VPVLAIVNEV YFRRTQPRPD LAEGRRRLDQ
160 170 180 190 200
KLALLKTPEL ADCVIADYGT RRRFSREWQE EVLLTMRRLL GPQLAGTSNV
210 220 230 240 250
HFARLHNMVP LGTMAHEYLQ ACQALGPRLR DSQVYALERW AREYRGDLGI
260 270 280 290 300
ALSDTYGFDA FLRDFDLYFC KLFDGVRHDS GDPMLWGERM VAHYAANRVD
310 320 330 340 350
PRTKTLIFSD SLDIPRVIEL YERFHGRCRL AFGVGTNLTN DLGYTPLQIV
360 370 380 390
IKMVRCNGQP VAKLSDTPEK TMCDDPGYLS YLRQVYSVQP AA
Length:392
Mass (Da):45,180
Last modified:October 3, 2006 - v1
Checksum:i0F32061160CA3A25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93672.1.
RefSeqiYP_727040.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93672; CAJ93672; H16_A2589.
GeneIDi4250031.
KEGGireh:H16_A2589.
PATRICi35234681. VBIRalEut6770_2975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93672.1 .
RefSeqi YP_727040.1. NC_008313.1.

3D structure databases

ProteinModelPortali Q0K8J9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_A2589.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ93672 ; CAJ93672 ; H16_A2589 .
GeneIDi 4250031.
KEGGi reh:H16_A2589.
PATRICi 35234681. VBIRalEut6770_2975.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi SIVCKVI.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci CNEC381666:GJUJ-2556-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiPNCB_CUPNH
AccessioniPrimary (citable) accession number: Q0K8J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3