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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei153 – 1531May be catalytically importantUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-2696-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:H16_A2731
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267GTP cyclohydrolase FolE2PRO_0000289514Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A2731.

Structurei

3D structure databases

ProteinModelPortaliQ0K861.
SMRiQ0K861. Positions 21-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDINPAFVM PDVQSSPDTR QIPIQRVGVK GVRYPVTLKT PAGIMPSVGT
60 70 80 90 100
FNLDVHLPAD QKGTHMSRFV ALLEEERAPL ELSSFRLMLD KMLEKLEAEA
110 120 130 140 150
GRIEVTFPYF ISKTAPVSGV ESLLDYEVTL TGEVRDGAAR VFLKALVPVT
160 170 180 190 200
SLCPCSKKIS QYGAHNQRSH ITMNVELAGE LPVEALVRMA EEEASCELWG
210 220 230 240 250
LLKRPDEKFV TERAYENPKF VEDLVRDIAM RLNADDRIVA YVLEAENFES
260
IHNHSAYAVI ERDKRVD
Length:267
Mass (Da):29,944
Last modified:October 3, 2006 - v1
Checksum:i8AA88FE03F084E11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93810.1.
RefSeqiWP_010813640.1. NC_008313.1.
YP_727178.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93810; CAJ93810; H16_A2731.
GeneIDi4249953.
KEGGireh:H16_A2731.
PATRICi35234987. VBIRalEut6770_3125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93810.1.
RefSeqiWP_010813640.1. NC_008313.1.
YP_727178.1. NC_008313.1.

3D structure databases

ProteinModelPortaliQ0K861.
SMRiQ0K861. Positions 21-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381666.H16_A2731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ93810; CAJ93810; H16_A2731.
GeneIDi4249953.
KEGGireh:H16_A2731.
PATRICi35234987. VBIRalEut6770_3125.

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BioCyciCNEC381666:GJUJ-2696-MONOMER.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiGCH4_CUPNH
AccessioniPrimary (citable) accession number: Q0K861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 3, 2006
Last modified: May 27, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.