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Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84L-glutamineUniRule annotation1
Binding sitei238L-glutamineUniRule annotation1
Binding sitei257ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 54ATPUniRule annotation3
Nucleotide bindingi58 – 64ATPUniRule annotation7
Nucleotide bindingi292 – 293ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligaseUniRule annotation (EC:6.1.1.18UniRule annotation)
Alternative name(s):
Glutaminyl-tRNA synthetaseUniRule annotation
Short name:
GlnRSUniRule annotation
Gene namesi
Name:glnSUniRule annotation
Ordered Locus Names:H16_A2784
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000008210 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000955051 – 585Glutamine--tRNA ligaseAdd BLAST585

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi381666.H16_A2784.

Structurei

3D structure databases

ProteinModelPortaliQ0K808.
SMRiQ0K808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 61"HIGH" regionUniRule annotationAdd BLAST11
Motifi299 – 303"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CX6. Bacteria.
COG0008. LUCA.
HOGENOMiHOG000259232.
KOiK01886.
OMAiVTHSICT.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 3 hits.
HAMAPiMF_00126. Gln_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0K808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHDNKPTDS TPAASNFLRS IIDQDLAAST YAGRQDKAGE PLPTVITRFP
60 70 80 90 100
PEPNGYLHIG HAKSICLNFG LARDYGGRCH LRFDDTNPVK EDTEYVDSII
110 120 130 140 150
DAVHWLGFSW DSEGKDGTRQ PHLYYASDYF DQLYAFAETL IERGAAYIDS
160 170 180 190 200
QTAEQIAASR GNFSEPGKPS PYRERSVEEN LQLFRDMRAG KYADGEHVLR
210 220 230 240 250
AKIDMTAPNI VMRDPVLYRI RHAHHHRTGD KWCIYPMYDF THCISDALEN
260 270 280 290 300
ITHSLCTLEF ENNRPLYDWV LEHLRDSGVF RDPLPHQYEF ARLNLTYAIT
310 320 330 340 350
SKRKLKQLVD EQRVDGWDDP RMPTLVGVRR RGYTPESIQL FCDRVGVAKA
360 370 380 390 400
DSWIDMSTLE GAVRDDLDGR AARGVAVLDP LKLIIDNYPE GQSEECSAPV
410 420 430 440 450
HPKKPELGKR VFPLSRELWI EREDFNETPP KGYFRLFPGN KVRLKYGYVI
460 470 480 490 500
ECTGVDKDAD GNVIAVHASY LPETKSGTPG ADSVKVKGVI HWVSAAHAYE
510 520 530 540 550
AEVRLYDRLF NDPNPDAGGK NFLDALNPDS KQVITAYLEP GLREAQPEDR
560 570 580
FQFERHGYFV ADRTDSQPGK PVFNRIVGLK DSWGK
Length:585
Mass (Da):66,386
Last modified:October 3, 2006 - v1
Checksum:i16C047BB5FCCF319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA. Translation: CAJ93863.1.
RefSeqiWP_011615831.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93863; CAJ93863; H16_A2784.
KEGGireh:H16_A2784.
PATRICifig|381666.6.peg.3182.

Similar proteinsi

Entry informationi

Entry nameiSYQ_CUPNH
AccessioniPrimary (citable) accession number: Q0K808
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 3, 2006
Last modified: August 30, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families