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Q0K7S5

- TRMB_CUPNH

UniProt

Q0K7S5 - TRMB_CUPNH

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, H16_A2870
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911S-adenosyl-L-methionine By similarity
Binding sitei116 – 1161S-adenosyl-L-methionine By similarity
Binding sitei143 – 1431S-adenosyl-L-methionine By similarity
Active sitei166 – 1661 By similarity
Binding sitei166 – 1661S-adenosyl-L-methionine By similarity
Binding sitei170 – 1701Substrate By similarity
Binding sitei202 – 2021Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-2834-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:H16_A2870
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000288207Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A2870.

Structurei

3D structure databases

ProteinModelPortaliQ0K7S5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 1776Interaction with RNA Reviewed prediction
Regioni240 – 2434Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiRERANAK.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K7S5-1 [UniParc]FASTAAdd to Basket

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MLPQDPSTEP TPADDAAPVD SAGQASAPSP ADPEGVAHPR RIRSFVRRAG    50
RTSTGQQRAI DEVGPRMMVP YAPQPLDWEA TFGRKAPSIL EIGFGMGETT 100
AHIAGLRPQD NFLGCEVHEP GVGALLKLID ERGLANVRIL QHDAVEVIAH 150
MLTDDCLDGV HIYFPDPWHK KRHNKRRLVQ PPLVKVLAAR LKPGGYIHCA 200
TDWEEYAHQM LEVLSGEPLL ENTSTAADGF AERPDYRPVT KFERRGVRLG 250
HGVWDVVFRK RAA 263
Length:263
Mass (Da):29,047
Last modified:October 3, 2006 - v1
Checksum:i28C58FFF3E1AE22B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260479 Genomic DNA. Translation: CAJ93946.1.
RefSeqiYP_727314.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93946; CAJ93946; H16_A2870.
GeneIDi4250530.
KEGGireh:H16_A2870.
PATRICi35235277. VBIRalEut6770_3268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260479 Genomic DNA. Translation: CAJ93946.1 .
RefSeqi YP_727314.1. NC_008313.1.

3D structure databases

ProteinModelPortali Q0K7S5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_A2870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ93946 ; CAJ93946 ; H16_A2870 .
GeneIDi 4250530.
KEGGi reh:H16_A2870.
PATRICi 35235277. VBIRalEut6770_3268.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi RERANAK.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CNEC381666:GJUJ-2834-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiTRMB_CUPNH
AccessioniPrimary (citable) accession number: Q0K7S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 3, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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