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Q0K7S4

- UPPP_CUPNH

UniProt

Q0K7S4 - UPPP_CUPNH

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, bacA, H16_A2871
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-2835-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA
Ordered Locus Names:H16_A2871
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Reviewed prediction
Add
BLAST
Transmembranei43 – 6321Helical; Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Transmembranei109 – 12921Helical; Reviewed prediction
Add
BLAST
Transmembranei178 – 19821Helical; Reviewed prediction
Add
BLAST
Transmembranei203 – 22321Helical; Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Undecaprenyl-diphosphataseUniRule annotation
PRO_0000290754Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A2871.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiVIYFRNE.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K7S4-1 [UniParc]FASTAAdd to Basket

« Hide

MEIALALKAV ILGIVEGLTE FLPISSTGHL ILAGQLLDFN DEKGKIFEIV    50
IQFGAILAVC WEFRARIGNV VRGLRAEPLA QRFAANVVIA SVPAIVLAFI 100
FGKWIKAHLF NPISVALAFI VGGVVILLAE WRDARRGTVS HPQGNALLEA 150
AKAGAPRIES VDDLNWRDAL KVGLAQCFAL VPGTSRSGAT IIGGMLFGLS 200
RQVATEFSFF LAIPVIFGAT VYELYKARAL LNGDDLGIFA VGFVFAFLSA 250
FLCVRWLLRF VATHDFKPFA WYRIAFGIVV LLTAYSGLVS WHA 293
Length:293
Mass (Da):31,822
Last modified:June 12, 2007 - v2
Checksum:iF019D4222EE39530
GO

Sequence cautioni

The sequence CAJ93947.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260479 Genomic DNA. Translation: CAJ93947.1. Different initiation.
RefSeqiWP_011615872.1. NC_008313.1.
YP_727315.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93947; CAJ93947; H16_A2871.
GeneIDi4246851.
KEGGireh:H16_A2871.
PATRICi35235279. VBIRalEut6770_3269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260479 Genomic DNA. Translation: CAJ93947.1 . Different initiation.
RefSeqi WP_011615872.1. NC_008313.1.
YP_727315.1. NC_008313.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 381666.H16_A2871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ93947 ; CAJ93947 ; H16_A2871 .
GeneIDi 4246851.
KEGGi reh:H16_A2871.
PATRICi 35235279. VBIRalEut6770_3269.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi VIYFRNE.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CNEC381666:GJUJ-2835-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiUPPP_CUPNH
AccessioniPrimary (citable) accession number: Q0K7S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi