Q0K6Y1 (UBIC_CUPNH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	H16_A3165

Organism

Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) [Complete proteome] [HAMAP]

Taxonomic identifier

381666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000292075
Sites
	Binding site	78	1	Substrate By similarity
	Binding site	116	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0K6Y1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: E36BE0F5F15D85A1	FASTA	220	25,025
	10 20 30 40 50 60 MSAQSARRCS WSPHLAFDAA ITPNLRRWVT GDDGSLTARL VAASERFRVA RLLQRPQRPL 70 80 90 100 110 120 ADEWQVLGQH DRTPALTREV LLICDDIPAI FAHTVVRQRH ARRDWPFLRG LGERPLGGRL 130 140 150 160 170 180 FVDPAVAREP FQFARLLPHH PLRQALQRVL PAMAPLPMLP ARRSVFRRGD GVMLVTEVFL 190 200 210 220 PDLLSRPSPG TEAIPYPRYL RTTDRSPSTH TTETKKETTR

References

[1]

"Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16." Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B. Nat. Biotechnol. 24:1257-1262(2006) [PubMed: 16964242] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM260479 Genomic DNA. Translation: CAJ94240.1.
RefSeq	YP_727608.1. NC_008313.1.
3D structure databases
ProteinModelPortal	Q0K6Y1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0K6Y1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4249993.
GenomeReviews	Gene locus H16_A3165 in contig AM260479_GR.
KEGG	reh:H16_A3165.
PATRIC	35235891. VBIRalEut6770_3574.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3161.
HOGENOM	HBG644467.
OMA	MNTSSGW.
ProtClustDB	CLSK939614.
Enzyme and pathway databases
BioCyc	REUT381666:H16_A3165-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
KO	K03181.
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_CUPNH

Accession

Primary (citable) accession number: Q0K6Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program