Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotationSAAS annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD), Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144NADUniRule annotation1
Binding sitei205NADUniRule annotation1
Binding sitei228NADUniRule annotation1
Binding sitei251SubstrateUniRule annotation1
Metal bindingi273ZincUniRule annotation1
Binding sitei273SubstrateUniRule annotation1
Metal bindingi276ZincUniRule annotation1
Binding sitei276SubstrateUniRule annotation1
Active sitei341Proton acceptorUniRule annotation1
Active sitei342Proton acceptorUniRule annotation1
Binding sitei342SubstrateUniRule annotation1
Metal bindingi375ZincUniRule annotation1
Binding sitei375SubstrateUniRule annotation1
Binding sitei429SubstrateUniRule annotation1
Metal bindingi434ZincUniRule annotation1
Binding sitei434SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.23UniRule annotationSAAS annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotationImported
Ordered Locus Names:H16_A3416Imported
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)Imported
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000008210 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A3416

Structurei

3D structure databases

ProteinModelPortaliQ0K687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0K687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATEMENLP IRRLDSSKPG FAEALRQVLA FEAGEDEAID RAAAQILADV
60 70 80 90 100
KARGDAAVLE YTRRFDRVEA SSMGALEVSQ QQLEAALEDL EPKRRAALEA
110 120 130 140 150
AAARVRAYHE KQKIECGSHS WEYTEADGTM LGQKVTPLDR VGIYVPGGKA
160 170 180 190 200
AYPSSVLMNA IPARVAGVKE IIMVVPTPGG VRNELVLAAA QIAGVDRVFT
210 220 230 240 250
IGGAQAIGAL AYGTATLPQV DKIVGPGNAY VAAAKRRVFG TVGIDMIAGP
260 270 280 290 300
SEILVICDGT TDPDWVAMDL FSQAEHDELA QSILLCPDAG YIARVEASIQ
310 320 330 340 350
RQLGTMPRRE VIAASISGRG ALIKVRDMEE ACEIANAIAP EHLEISAENP
360 370 380 390 400
RQWSEKIRHA GAIFLGPYTS ESLGDYCAGP NHVLPTSRTA RFSSPLGVYD
410 420 430 440
FQKRSSLIEV SEGGAQMLGQ IAAELAYGEG LQAHARSAEY RFTKRS
Length:446
Mass (Da):47,806
Last modified:October 3, 2006 - v1
Checksum:iEF335B2EB27D7B0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260479 Genomic DNA Translation: CAJ94484.1
RefSeqiWP_010812332.1, NC_008313.1

Genome annotation databases

EnsemblBacteriaiCAJ94484; CAJ94484; H16_A3416
KEGGireh:H16_A3416
PATRICifig|381666.6.peg.3809

Similar proteinsi

Entry informationi

Entry nameiQ0K687_CUPNH
AccessioniPrimary (citable) accession number: Q0K687
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health