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Q0K687

- Q0K687_CUPNH

UniProt

Q0K687 - Q0K687_CUPNH

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotationSAAS annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei144 – 1441NADUniRule annotation
    Binding sitei205 – 2051NADUniRule annotation
    Binding sitei228 – 2281NADUniRule annotation
    Binding sitei251 – 2511SubstrateUniRule annotation
    Metal bindingi273 – 2731ZincUniRule annotation
    Binding sitei273 – 2731SubstrateUniRule annotation
    Metal bindingi276 – 2761ZincUniRule annotation
    Binding sitei276 – 2761SubstrateUniRule annotation
    Active sitei341 – 3411Proton acceptorUniRule annotation
    Active sitei342 – 3421Proton acceptorUniRule annotation
    Binding sitei342 – 3421SubstrateUniRule annotation
    Metal bindingi375 – 3751ZincUniRule annotation
    Binding sitei375 – 3751SubstrateUniRule annotation
    Binding sitei429 – 4291SubstrateUniRule annotation
    Metal bindingi434 – 4341ZincUniRule annotation
    Binding sitei434 – 4341SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCNEC381666:GJUJ-3380-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotationImported
    Ordered Locus Names:H16_A3416Imported
    OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)Imported
    Taxonomic identifieri381666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000008210: Chromosome 1

    Interactioni

    Protein-protein interaction databases

    STRINGi381666.H16_A3416.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0K687.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiCAIANRI.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0K687-1 [UniParc]FASTAAdd to Basket

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    MNATEMENLP IRRLDSSKPG FAEALRQVLA FEAGEDEAID RAAAQILADV    50
    KARGDAAVLE YTRRFDRVEA SSMGALEVSQ QQLEAALEDL EPKRRAALEA 100
    AAARVRAYHE KQKIECGSHS WEYTEADGTM LGQKVTPLDR VGIYVPGGKA 150
    AYPSSVLMNA IPARVAGVKE IIMVVPTPGG VRNELVLAAA QIAGVDRVFT 200
    IGGAQAIGAL AYGTATLPQV DKIVGPGNAY VAAAKRRVFG TVGIDMIAGP 250
    SEILVICDGT TDPDWVAMDL FSQAEHDELA QSILLCPDAG YIARVEASIQ 300
    RQLGTMPRRE VIAASISGRG ALIKVRDMEE ACEIANAIAP EHLEISAENP 350
    RQWSEKIRHA GAIFLGPYTS ESLGDYCAGP NHVLPTSRTA RFSSPLGVYD 400
    FQKRSSLIEV SEGGAQMLGQ IAAELAYGEG LQAHARSAEY RFTKRS 446
    Length:446
    Mass (Da):47,806
    Last modified:October 3, 2006 - v1
    Checksum:iEF335B2EB27D7B0F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260479 Genomic DNA. Translation: CAJ94484.1.
    RefSeqiYP_727852.1. NC_008313.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ94484; CAJ94484; H16_A3416.
    GeneIDi4247065.
    KEGGireh:H16_A3416.
    PATRICi35236377. VBIRalEut6770_3809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260479 Genomic DNA. Translation: CAJ94484.1 .
    RefSeqi YP_727852.1. NC_008313.1.

    3D structure databases

    ProteinModelPortali Q0K687.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381666.H16_A3416.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ94484 ; CAJ94484 ; H16_A3416 .
    GeneIDi 4247065.
    KEGGi reh:H16_A3416.
    PATRICi 35236377. VBIRalEut6770_3809.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi CAIANRI.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci CNEC381666:GJUJ-3380-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337Imported.

    Entry informationi

    Entry nameiQ0K687_CUPNH
    AccessioniPrimary (citable) accession number: Q0K687
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3