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Q0K687

- Q0K687_CUPNH

UniProt

Q0K687 - Q0K687_CUPNH

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Protein

Histidinol dehydrogenase

Gene
hisD, H16_A3416
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotationSAAS annotations

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotationSAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei144 – 1441NAD By similarityUniRule annotation
Binding sitei205 – 2051NAD By similarityUniRule annotation
Binding sitei228 – 2281NAD By similarityUniRule annotation
Binding sitei251 – 2511Substrate By similarityUniRule annotation
Metal bindingi273 – 2731Zinc By similarityUniRule annotation
Binding sitei273 – 2731Substrate By similarityUniRule annotation
Metal bindingi276 – 2761Zinc By similarityUniRule annotation
Binding sitei276 – 2761Substrate By similarityUniRule annotation
Active sitei341 – 3411Proton acceptor By similarityUniRule annotation
Active sitei342 – 3421Proton acceptor By similarityUniRule annotation
Binding sitei342 – 3421Substrate By similarityUniRule annotation
Metal bindingi375 – 3751Zinc By similarityUniRule annotation
Binding sitei375 – 3751Substrate By similarityUniRule annotation
Binding sitei429 – 4291Substrate By similarityUniRule annotation
Metal bindingi434 – 4341Zinc By similarityUniRule annotation
Binding sitei434 – 4341Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, NADUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-3380-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotationImported
Ordered Locus Names:H16_A3416Imported
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)Imported
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_A3416.

Structurei

3D structure databases

ProteinModelPortaliQ0K687.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiCAIANRI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K687-1 [UniParc]FASTAAdd to Basket

« Hide

MNATEMENLP IRRLDSSKPG FAEALRQVLA FEAGEDEAID RAAAQILADV    50
KARGDAAVLE YTRRFDRVEA SSMGALEVSQ QQLEAALEDL EPKRRAALEA 100
AAARVRAYHE KQKIECGSHS WEYTEADGTM LGQKVTPLDR VGIYVPGGKA 150
AYPSSVLMNA IPARVAGVKE IIMVVPTPGG VRNELVLAAA QIAGVDRVFT 200
IGGAQAIGAL AYGTATLPQV DKIVGPGNAY VAAAKRRVFG TVGIDMIAGP 250
SEILVICDGT TDPDWVAMDL FSQAEHDELA QSILLCPDAG YIARVEASIQ 300
RQLGTMPRRE VIAASISGRG ALIKVRDMEE ACEIANAIAP EHLEISAENP 350
RQWSEKIRHA GAIFLGPYTS ESLGDYCAGP NHVLPTSRTA RFSSPLGVYD 400
FQKRSSLIEV SEGGAQMLGQ IAAELAYGEG LQAHARSAEY RFTKRS 446
Length:446
Mass (Da):47,806
Last modified:October 3, 2006 - v1
Checksum:iEF335B2EB27D7B0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260479 Genomic DNA. Translation: CAJ94484.1.
RefSeqiYP_727852.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ94484; CAJ94484; H16_A3416.
GeneIDi4247065.
KEGGireh:H16_A3416.
PATRICi35236377. VBIRalEut6770_3809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260479 Genomic DNA. Translation: CAJ94484.1 .
RefSeqi YP_727852.1. NC_008313.1.

3D structure databases

ProteinModelPortali Q0K687.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_A3416.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ94484 ; CAJ94484 ; H16_A3416 .
GeneIDi 4247065.
KEGGi reh:H16_A3416.
PATRICi 35236377. VBIRalEut6770_3809.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi CAIANRI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CNEC381666:GJUJ-3380-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiQ0K687_CUPNH
AccessioniPrimary (citable) accession number: Q0K687
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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