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Q0K3S6

- ACDH1_CUPNH

UniProt

Q0K3S6 - ACDH1_CUPNH

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Protein

Acetaldehyde dehydrogenase 1

Gene

mhpF

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei134 – 1341Acyl-thioester intermediateUniRule annotation
Binding sitei292 – 2921NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 194NADUniRule annotation
Nucleotide bindingi165 – 1739NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-4258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:H16_B0551
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Acetaldehyde dehydrogenase 1PRO_0000387712Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_B0551.

Structurei

3D structure databases

ProteinModelPortaliQ0K3S6.
SMRiQ0K3S6. Positions 10-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiSIYLEIE.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0K3S6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDMKASGHHK VAIIGSGNIG TDLMIKVMRH GRSLEMGAMV GIDAASDGLA
60 70 80 90 100
RAARLGVPTT AEGIDGLVGM PGFGDIRIAF DATSAGAHAH HNRVLQQHGV
110 120 130 140 150
RVIDLTPASI GPYVVPVVNL DQHLDAPNIN MVTCGGQATI PMVAAVSRVA
160 170 180 190 200
RVHYAEIVAS ISSRSAGPGT RANIDEFTET TSQALCSVGG AARGKAIIVL
210 220 230 240 250
NPAEPPLMMR DTVFTLSEDG DEAEIAASVE AMAQAVQGYV PGYRLKQRVQ
260 270 280 290 300
FERIAASAPL NIPGLGPMSG LKTSIFLEVE GAAHYLPAYA GNLDIMTSAA
310
LACAERLAET RLSA
Length:314
Mass (Da):32,641
Last modified:October 3, 2006 - v1
Checksum:i4A5EF61AA381D412
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260480 Genomic DNA. Translation: CAJ95348.1.
RefSeqiYP_728713.1. NC_008314.1.

Genome annotation databases

EnsemblBacteriaiCAJ95348; CAJ95348; H16_B0551.
GeneIDi4456316.
KEGGireh:H16_B0551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260480 Genomic DNA. Translation: CAJ95348.1 .
RefSeqi YP_728713.1. NC_008314.1.

3D structure databases

ProteinModelPortali Q0K3S6.
SMRi Q0K3S6. Positions 10-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_B0551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ95348 ; CAJ95348 ; H16_B0551 .
GeneIDi 4456316.
KEGGi reh:H16_B0551.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi SIYLEIE.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci CNEC381666:GJUJ-4258-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiACDH1_CUPNH
AccessioniPrimary (citable) accession number: Q0K3S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 3, 2006
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3