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Protein

Acetaldehyde dehydrogenase 1

Gene

mhpF

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134Acyl-thioester intermediateUniRule annotation1
Binding sitei292NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 19NADUniRule annotation4
Nucleotide bindingi165 – 173NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:H16_B0551
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000008210 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877121 – 314Acetaldehyde dehydrogenase 1Add BLAST314

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_B0551.

Structurei

3D structure databases

ProteinModelPortaliQ0K3S6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV. Bacteria.
COG4569. LUCA.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHARHEQL.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0K3S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMKASGHHK VAIIGSGNIG TDLMIKVMRH GRSLEMGAMV GIDAASDGLA
60 70 80 90 100
RAARLGVPTT AEGIDGLVGM PGFGDIRIAF DATSAGAHAH HNRVLQQHGV
110 120 130 140 150
RVIDLTPASI GPYVVPVVNL DQHLDAPNIN MVTCGGQATI PMVAAVSRVA
160 170 180 190 200
RVHYAEIVAS ISSRSAGPGT RANIDEFTET TSQALCSVGG AARGKAIIVL
210 220 230 240 250
NPAEPPLMMR DTVFTLSEDG DEAEIAASVE AMAQAVQGYV PGYRLKQRVQ
260 270 280 290 300
FERIAASAPL NIPGLGPMSG LKTSIFLEVE GAAHYLPAYA GNLDIMTSAA
310
LACAERLAET RLSA
Length:314
Mass (Da):32,641
Last modified:October 3, 2006 - v1
Checksum:i4A5EF61AA381D412
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260480 Genomic DNA. Translation: CAJ95348.1.
RefSeqiWP_010810409.1. NC_008314.1.

Genome annotation databases

EnsemblBacteriaiCAJ95348; CAJ95348; H16_B0551.
GeneIDi4456316.
KEGGireh:H16_B0551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260480 Genomic DNA. Translation: CAJ95348.1.
RefSeqiWP_010810409.1. NC_008314.1.

3D structure databases

ProteinModelPortaliQ0K3S6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381666.H16_B0551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ95348; CAJ95348; H16_B0551.
GeneIDi4456316.
KEGGireh:H16_B0551.

Phylogenomic databases

eggNOGiENOG4105DIV. Bacteria.
COG4569. LUCA.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHARHEQL.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACDH1_CUPNH
AccessioniPrimary (citable) accession number: Q0K3S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.