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Q0K3S6

- ACDH1_CUPNH

UniProt

Q0K3S6 - ACDH1_CUPNH

Protein

Acetaldehyde dehydrogenase 1

Gene

mhpF

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei134 – 1341Acyl-thioester intermediateUniRule annotation
    Binding sitei292 – 2921NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 194NADUniRule annotation
    Nucleotide bindingi165 – 1739NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCNEC381666:GJUJ-4258-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
    Gene namesi
    Name:mhpFUniRule annotation
    Ordered Locus Names:H16_B0551
    OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
    Taxonomic identifieri381666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000008210: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Acetaldehyde dehydrogenase 1PRO_0000387712Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381666.H16_B0551.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0K3S6.
    SMRiQ0K3S6. Positions 10-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiSIYLEIE.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0K3S6-1 [UniParc]FASTAAdd to Basket

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    MDMKASGHHK VAIIGSGNIG TDLMIKVMRH GRSLEMGAMV GIDAASDGLA    50
    RAARLGVPTT AEGIDGLVGM PGFGDIRIAF DATSAGAHAH HNRVLQQHGV 100
    RVIDLTPASI GPYVVPVVNL DQHLDAPNIN MVTCGGQATI PMVAAVSRVA 150
    RVHYAEIVAS ISSRSAGPGT RANIDEFTET TSQALCSVGG AARGKAIIVL 200
    NPAEPPLMMR DTVFTLSEDG DEAEIAASVE AMAQAVQGYV PGYRLKQRVQ 250
    FERIAASAPL NIPGLGPMSG LKTSIFLEVE GAAHYLPAYA GNLDIMTSAA 300
    LACAERLAET RLSA 314
    Length:314
    Mass (Da):32,641
    Last modified:October 3, 2006 - v1
    Checksum:i4A5EF61AA381D412
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260480 Genomic DNA. Translation: CAJ95348.1.
    RefSeqiYP_728713.1. NC_008314.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ95348; CAJ95348; H16_B0551.
    GeneIDi4456316.
    KEGGireh:H16_B0551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260480 Genomic DNA. Translation: CAJ95348.1 .
    RefSeqi YP_728713.1. NC_008314.1.

    3D structure databases

    ProteinModelPortali Q0K3S6.
    SMRi Q0K3S6. Positions 10-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381666.H16_B0551.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ95348 ; CAJ95348 ; H16_B0551 .
    GeneIDi 4456316.
    KEGGi reh:H16_B0551.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi SIYLEIE.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci CNEC381666:GJUJ-4258-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

    Entry informationi

    Entry nameiACDH1_CUPNH
    AccessioniPrimary (citable) accession number: Q0K3S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3