Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0K3R9

- RBKTP_CUPNH

UniProt

Q0K3R9 - RBKTP_CUPNH

Protein

Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Gene

phnN

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).By similarity

    Catalytic activityi

    ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorylase activity Source: InterPro
    3. ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC
    4. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. organic phosphonate transport Source: UniProtKB-KW
    3. pyrimidine nucleobase metabolic process Source: InterPro
    4. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Alkylphosphonate uptake

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCNEC381666:GJUJ-4265-MONOMER.
    UniPathwayiUPA00087; UER00175.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
    Including the following 2 domains:
    Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
    Alternative name(s):
    Ribose 1,5-bisphosphokinase
    Putative thymidine phosphorylase (EC:2.4.2.4)
    Alternative name(s):
    TdRPase
    Gene namesi
    Name:phnN
    Ordered Locus Names:H16_B0558
    OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
    Taxonomic identifieri381666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000008210: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylasePRO_0000314709Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381666.H16_B0558.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0K3R9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 177177Ribose 1,5-bisphosphokinaseAdd
    BLAST
    Regioni178 – 601424ThymidinephosphorylaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.Curated
    In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiCLIWGGH.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02322. phosphon_PhnN. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0K3R9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKATGTFFFV VGPSGAGKDS LIDGARAALD GDYVFARRVI TRPDGSAGEE    50
    HEGVTEAEFA RRQRSGEFLV TWDAHDLRYG LPKSLMCELE RGRNVVANGS 100
    RGVIAELAAR LPRFVVVLVT APHDVLARRI AARGRESGDQ VASRVARAGA 150
    PVPPHVPCIT VSNHSTLEAG TARFVEALRT GTRTSAAERP ASRTNLMAKL 200
    RGEPLDEAAY VAVLQDAIAG RYTEAELTEF LVAATRTLTD EEVVALARAR 250
    TAFTPRIDWD EPVVVDKHSM GGVPGSRITL IVVPIVAAYG LAMPKTSSRA 300
    ITSAAGTADA METIARVDLA HEDVRRCVAQ ARACIAWNGR LNHSVVDDVM 350
    NAITRPLRLD SRRWSVASIL SKKYTAGATH VIVDLPYGPQ TKLATRADAE 400
    ALGALFEHVG KGLGLHVRAL VTDGSGPIGR GIGPALEVRD VRLVLDNAPD 450
    APADLRDKAL RFAGEIIAFD PRVDSPEHGM QIAAALLHEG KARAAFDRIA 500
    AAQGVRCDPV APGTHTLVVP ATTRGRVAGV DGLQISGVAR AAGAPRDGGA 550
    GVDMLCAIGA KVAPGQPLYR IHSDSAEALE AAAALVRAGG ECCQAVRIDP 600
    D 601
    Length:601
    Mass (Da):63,353
    Last modified:October 3, 2006 - v1
    Checksum:i99B7554ACC47C203
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260480 Genomic DNA. Translation: CAJ95355.1.
    RefSeqiYP_728720.1. NC_008314.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ95355; CAJ95355; H16_B0558.
    GeneIDi4456323.
    KEGGireh:H16_B0558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260480 Genomic DNA. Translation: CAJ95355.1 .
    RefSeqi YP_728720.1. NC_008314.1.

    3D structure databases

    ProteinModelPortali Q0K3R9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381666.H16_B0558.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ95355 ; CAJ95355 ; H16_B0558 .
    GeneIDi 4456323.
    KEGGi reh:H16_B0558.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi CLIWGGH.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00087 ; UER00175 .
    BioCyci CNEC381666:GJUJ-4265-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02322. phosphon_PhnN. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

    Entry informationi

    Entry nameiRBKTP_CUPNH
    AccessioniPrimary (citable) accession number: Q0K3R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3