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Q0K3R9

- RBKTP_CUPNH

UniProt

Q0K3R9 - RBKTP_CUPNH

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Protein

Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Gene

phnN

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).By similarity

Catalytic activityi

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorylase activity Source: InterPro
  3. ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC
  4. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. organic phosphonate transport Source: UniProtKB-KW
  3. pyrimidine nucleobase metabolic process Source: InterPro
  4. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Alkylphosphonate uptake

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-4265-MONOMER.
UniPathwayiUPA00087; UER00175.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
Including the following 2 domains:
Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
Alternative name(s):
Ribose 1,5-bisphosphokinase
Putative thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:phnN
Ordered Locus Names:H16_B0558
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylasePRO_0000314709Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_B0558.

Structurei

3D structure databases

ProteinModelPortaliQ0K3R9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 177177Ribose 1,5-bisphosphokinaseAdd
BLAST
Regioni178 – 601424ThymidinephosphorylaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.Curated
In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiCLIWGGH.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02322. phosphon_PhnN. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K3R9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKATGTFFFV VGPSGAGKDS LIDGARAALD GDYVFARRVI TRPDGSAGEE
60 70 80 90 100
HEGVTEAEFA RRQRSGEFLV TWDAHDLRYG LPKSLMCELE RGRNVVANGS
110 120 130 140 150
RGVIAELAAR LPRFVVVLVT APHDVLARRI AARGRESGDQ VASRVARAGA
160 170 180 190 200
PVPPHVPCIT VSNHSTLEAG TARFVEALRT GTRTSAAERP ASRTNLMAKL
210 220 230 240 250
RGEPLDEAAY VAVLQDAIAG RYTEAELTEF LVAATRTLTD EEVVALARAR
260 270 280 290 300
TAFTPRIDWD EPVVVDKHSM GGVPGSRITL IVVPIVAAYG LAMPKTSSRA
310 320 330 340 350
ITSAAGTADA METIARVDLA HEDVRRCVAQ ARACIAWNGR LNHSVVDDVM
360 370 380 390 400
NAITRPLRLD SRRWSVASIL SKKYTAGATH VIVDLPYGPQ TKLATRADAE
410 420 430 440 450
ALGALFEHVG KGLGLHVRAL VTDGSGPIGR GIGPALEVRD VRLVLDNAPD
460 470 480 490 500
APADLRDKAL RFAGEIIAFD PRVDSPEHGM QIAAALLHEG KARAAFDRIA
510 520 530 540 550
AAQGVRCDPV APGTHTLVVP ATTRGRVAGV DGLQISGVAR AAGAPRDGGA
560 570 580 590 600
GVDMLCAIGA KVAPGQPLYR IHSDSAEALE AAAALVRAGG ECCQAVRIDP

D
Length:601
Mass (Da):63,353
Last modified:October 3, 2006 - v1
Checksum:i99B7554ACC47C203
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260480 Genomic DNA. Translation: CAJ95355.1.
RefSeqiYP_728720.1. NC_008314.1.

Genome annotation databases

EnsemblBacteriaiCAJ95355; CAJ95355; H16_B0558.
GeneIDi4456323.
KEGGireh:H16_B0558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260480 Genomic DNA. Translation: CAJ95355.1 .
RefSeqi YP_728720.1. NC_008314.1.

3D structure databases

ProteinModelPortali Q0K3R9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_B0558.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ95355 ; CAJ95355 ; H16_B0558 .
GeneIDi 4456323.
KEGGi reh:H16_B0558.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi CLIWGGH.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

UniPathwayi UPA00087 ; UER00175 .
BioCyci CNEC381666:GJUJ-4265-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPi MF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02322. phosphon_PhnN. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiRBKTP_CUPNH
AccessioniPrimary (citable) accession number: Q0K3R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2006
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3