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Q0K3Q9

- Q0K3Q9_CUPNH

UniProt

Q0K3Q9 - Q0K3Q9_CUPNH

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Protein
Aconitate hydratase 2
Gene
acnB, H16_B0568
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.UniRule annotation
Citrate = isocitrate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-methylisocitrate dehydratase activity Source: UniProtKB-EC
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. aconitate hydratase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

4Fe-4SSAAS annotations, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-4275-MONOMER.
UniPathwayiUPA00223; UER00718.

Names & Taxonomyi

Protein namesi
Recommended name:
Aconitate hydratase 2UniRule annotation (EC:4.2.1.3UniRule annotation, EC:4.2.1.99UniRule annotation)
Alternative name(s):
2-methylisocitrate dehydratase
Gene namesi
Name:acnBImported
Ordered Locus Names:H16_B0568Imported
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)Imported
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_B0568.

Structurei

3D structure databases

ProteinModelPortaliQ0K3Q9.
SMRiQ0K3Q9. Positions 1-861.

Family & Domainsi

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1049.
HOGENOMiHOG000205991.
KOiK01682.
OMAiPTRMDQQ.
OrthoDBiEOG6N944W.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR004406. Aconitase_B_bac.
IPR015933. Aconitase_B_HEAT-like_bac.
IPR015929. Aconitase_B_N_bac.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00330. Aconitase. 2 hits.
PF06434. Aconitase_2_N. 1 hit.
PF11791. Aconitase_B_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036687. AcnB. 1 hit.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
SSF74778. SSF74778. 1 hit.
TIGRFAMsiTIGR00117. acnB. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K3Q9-1 [UniParc]FASTAAdd to Basket

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MLENYRAHVA ERAALGIPPL PLTAKQTAEL VELLKNPPAG EEQTLVELIT    50
YRVPAGVDDA AKVKASYLAA VALGKEKCAL ISRAKATELL GTMLGGYNIS 100
PLIELLDDAE VGTVAAEALK KTLLMFDAFH DVKEKADQGN ANAKAVLQSW 150
ADAEWFTSRP EVPQSLTITV FKVPGETNTD DLSPAPDATT RPDIPMHALA 200
MLKNKREGAA FQPEEDGKRG PVKFIESLKE KGHLVAYVGD VVGTGSSRKS 250
ATNSVLWFTG EDIPFIPNKR FGGVCLGNKI APIFYNTMED AGALPIELDV 300
SKMEMGDVVE LRPYEGKALK DGAVIAEFKV KSDVLFDEVR AGGRIPLIVG 350
RGLTAKAREA LGLAPSTLFR LPQNPADTGR GFTLAQKMVG RACGLPEGKG 400
IRPGTYCEPK MTSVGSQDTT GPMTRDELKD LACLGFSADL VMQSFCHTAA 450
YPKPVDVKTH HTLPEFISTR GGISLRPGDG VIHSWLNRML LPDTVGTGGD 500
SHTRFPIGIS FPAGSGLVAF AAATGVMPLD MPESVLVRFK GKMQPGVTLR 550
DLVNAIPLYA IKQGLLTVAK QGKKNIFSGR VLEIEGLPDL KVEQAFELSD 600
ASAERSAAGC TVRLNKDPII EYINSNITLL KWMIAQGYQD PRSLQRRIKA 650
MEAWLADPKL LEPDADAEYA AVIEIDLADV HEPIVACPND PDDVKTLSEV 700
AGAKIDEVFI GSCMTNIGHF RAASKLLEGK RDIPVKLWVA PPTKMDQKQL 750
TEEGHYGVFG TAGARTEMPG CSLCMGNQAQ VREGATVMST STRNFPNRLG 800
KNTNVYLGSA ELAAICSRLG RIPTKEEYMA DMGVLNANGD KIYKYMNFDQ 850
IEDFKEVADG VTV 863
Length:863
Mass (Da):93,126
Last modified:October 3, 2006 - v1
Checksum:i6624228948299E1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260480 Genomic DNA. Translation: CAJ95365.1.
RefSeqiYP_728730.1. NC_008314.1.

Genome annotation databases

EnsemblBacteriaiCAJ95365; CAJ95365; H16_B0568.
GeneIDi4456731.
KEGGireh:H16_B0568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260480 Genomic DNA. Translation: CAJ95365.1 .
RefSeqi YP_728730.1. NC_008314.1.

3D structure databases

ProteinModelPortali Q0K3Q9.
SMRi Q0K3Q9. Positions 1-861.
ModBasei Search...

Protein-protein interaction databases

STRINGi 381666.H16_B0568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ95365 ; CAJ95365 ; H16_B0568 .
GeneIDi 4456731.
KEGGi reh:H16_B0568.

Phylogenomic databases

eggNOGi COG1049.
HOGENOMi HOG000205991.
KOi K01682.
OMAi PTRMDQQ.
OrthoDBi EOG6N944W.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00718 .
BioCyci CNEC381666:GJUJ-4275-MONOMER.

Family and domain databases

Gene3Di 3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProi IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR004406. Aconitase_B_bac.
IPR015933. Aconitase_B_HEAT-like_bac.
IPR015929. Aconitase_B_N_bac.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
Pfami PF00330. Aconitase. 2 hits.
PF06434. Aconitase_2_N. 1 hit.
PF11791. Aconitase_B_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF036687. AcnB. 1 hit.
SUPFAMi SSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
SSF74778. SSF74778. 1 hit.
TIGRFAMsi TIGR00117. acnB. 1 hit.
PROSITEi PS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiQ0K3Q9_CUPNH
AccessioniPrimary (citable) accession number: Q0K3Q9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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