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Q0K3Q9

- Q0K3Q9_CUPNH

UniProt

Q0K3Q9 - Q0K3Q9_CUPNH

Protein

Aconitate hydratase 2

Gene

acnB

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.UniRule annotation
    Citrate = isocitrate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-methylisocitrate dehydratase activity Source: UniProtKB-EC
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. aconitate hydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    4Fe-4SSAAS annotation, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciCNEC381666:GJUJ-4275-MONOMER.
    UniPathwayiUPA00223; UER00718.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aconitate hydratase 2UniRule annotation (EC:4.2.1.3UniRule annotation, EC:4.2.1.99UniRule annotation)
    Alternative name(s):
    2-methylisocitrate dehydrataseUniRule annotation
    Gene namesi
    Name:acnBImported
    Ordered Locus Names:H16_B0568Imported
    OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)Imported
    Taxonomic identifieri381666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000008210: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi381666.H16_B0568.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0K3Q9.
    SMRiQ0K3Q9. Positions 1-861.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aconitase/IPM isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1049.
    HOGENOMiHOG000205991.
    KOiK01682.
    OMAiPTRMDQQ.
    OrthoDBiEOG6N944W.

    Family and domain databases

    Gene3Di3.20.19.10. 1 hit.
    3.30.499.10. 2 hits.
    3.40.1060.10. 1 hit.
    InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
    IPR015937. Acoase/IPM_deHydtase.
    IPR001030. Acoase/IPM_deHydtase_lsu_aba.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
    IPR018136. Aconitase_4Fe-4S_BS.
    IPR004406. Aconitase_B_bac.
    IPR015933. Aconitase_B_HEAT-like_bac.
    IPR015929. Aconitase_B_N_bac.
    [Graphical view]
    PANTHERiPTHR11670. PTHR11670. 1 hit.
    PfamiPF00330. Aconitase. 2 hits.
    PF06434. Aconitase_2_N. 1 hit.
    PF11791. Aconitase_B_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036687. AcnB. 1 hit.
    SUPFAMiSSF52016. SSF52016. 1 hit.
    SSF53732. SSF53732. 1 hit.
    SSF74778. SSF74778. 1 hit.
    TIGRFAMsiTIGR00117. acnB. 1 hit.
    PROSITEiPS00450. ACONITASE_1. 1 hit.
    PS01244. ACONITASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0K3Q9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLENYRAHVA ERAALGIPPL PLTAKQTAEL VELLKNPPAG EEQTLVELIT    50
    YRVPAGVDDA AKVKASYLAA VALGKEKCAL ISRAKATELL GTMLGGYNIS 100
    PLIELLDDAE VGTVAAEALK KTLLMFDAFH DVKEKADQGN ANAKAVLQSW 150
    ADAEWFTSRP EVPQSLTITV FKVPGETNTD DLSPAPDATT RPDIPMHALA 200
    MLKNKREGAA FQPEEDGKRG PVKFIESLKE KGHLVAYVGD VVGTGSSRKS 250
    ATNSVLWFTG EDIPFIPNKR FGGVCLGNKI APIFYNTMED AGALPIELDV 300
    SKMEMGDVVE LRPYEGKALK DGAVIAEFKV KSDVLFDEVR AGGRIPLIVG 350
    RGLTAKAREA LGLAPSTLFR LPQNPADTGR GFTLAQKMVG RACGLPEGKG 400
    IRPGTYCEPK MTSVGSQDTT GPMTRDELKD LACLGFSADL VMQSFCHTAA 450
    YPKPVDVKTH HTLPEFISTR GGISLRPGDG VIHSWLNRML LPDTVGTGGD 500
    SHTRFPIGIS FPAGSGLVAF AAATGVMPLD MPESVLVRFK GKMQPGVTLR 550
    DLVNAIPLYA IKQGLLTVAK QGKKNIFSGR VLEIEGLPDL KVEQAFELSD 600
    ASAERSAAGC TVRLNKDPII EYINSNITLL KWMIAQGYQD PRSLQRRIKA 650
    MEAWLADPKL LEPDADAEYA AVIEIDLADV HEPIVACPND PDDVKTLSEV 700
    AGAKIDEVFI GSCMTNIGHF RAASKLLEGK RDIPVKLWVA PPTKMDQKQL 750
    TEEGHYGVFG TAGARTEMPG CSLCMGNQAQ VREGATVMST STRNFPNRLG 800
    KNTNVYLGSA ELAAICSRLG RIPTKEEYMA DMGVLNANGD KIYKYMNFDQ 850
    IEDFKEVADG VTV 863
    Length:863
    Mass (Da):93,126
    Last modified:October 3, 2006 - v1
    Checksum:i6624228948299E1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260480 Genomic DNA. Translation: CAJ95365.1.
    RefSeqiYP_728730.1. NC_008314.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ95365; CAJ95365; H16_B0568.
    GeneIDi4456731.
    KEGGireh:H16_B0568.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM260480 Genomic DNA. Translation: CAJ95365.1 .
    RefSeqi YP_728730.1. NC_008314.1.

    3D structure databases

    ProteinModelPortali Q0K3Q9.
    SMRi Q0K3Q9. Positions 1-861.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381666.H16_B0568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ95365 ; CAJ95365 ; H16_B0568 .
    GeneIDi 4456731.
    KEGGi reh:H16_B0568.

    Phylogenomic databases

    eggNOGi COG1049.
    HOGENOMi HOG000205991.
    KOi K01682.
    OMAi PTRMDQQ.
    OrthoDBi EOG6N944W.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00718 .
    BioCyci CNEC381666:GJUJ-4275-MONOMER.

    Family and domain databases

    Gene3Di 3.20.19.10. 1 hit.
    3.30.499.10. 2 hits.
    3.40.1060.10. 1 hit.
    InterProi IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
    IPR015937. Acoase/IPM_deHydtase.
    IPR001030. Acoase/IPM_deHydtase_lsu_aba.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
    IPR018136. Aconitase_4Fe-4S_BS.
    IPR004406. Aconitase_B_bac.
    IPR015933. Aconitase_B_HEAT-like_bac.
    IPR015929. Aconitase_B_N_bac.
    [Graphical view ]
    PANTHERi PTHR11670. PTHR11670. 1 hit.
    Pfami PF00330. Aconitase. 2 hits.
    PF06434. Aconitase_2_N. 1 hit.
    PF11791. Aconitase_B_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036687. AcnB. 1 hit.
    SUPFAMi SSF52016. SSF52016. 1 hit.
    SSF53732. SSF53732. 1 hit.
    SSF74778. SSF74778. 1 hit.
    TIGRFAMsi TIGR00117. acnB. 1 hit.
    PROSITEi PS00450. ACONITASE_1. 1 hit.
    PS01244. ACONITASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337Imported.

    Entry informationi

    Entry nameiQ0K3Q9_CUPNH
    AccessioniPrimary (citable) accession number: Q0K3Q9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3