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Q0K3Q9

- Q0K3Q9_CUPNH

UniProt

Q0K3Q9 - Q0K3Q9_CUPNH

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Protein

Aconitate hydratase 2

Gene

acnB

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.UniRule annotation
Citrate = isocitrate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-methylisocitrate dehydratase activity Source: UniProtKB-EC
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. aconitate hydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

4Fe-4SSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-4275-MONOMER.
UniPathwayiUPA00223; UER00718.

Names & Taxonomyi

Protein namesi
Recommended name:
Aconitate hydratase 2UniRule annotation (EC:4.2.1.3UniRule annotation, EC:4.2.1.99UniRule annotation)
Alternative name(s):
2-methylisocitrate dehydrataseUniRule annotation
Gene namesi
Name:acnBImported
Ordered Locus Names:H16_B0568Imported
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)Imported
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_B0568.

Structurei

3D structure databases

ProteinModelPortaliQ0K3Q9.
SMRiQ0K3Q9. Positions 1-861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1049.
HOGENOMiHOG000205991.
KOiK01682.
OMAiPTRMDQQ.
OrthoDBiEOG6N944W.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR004406. Aconitase_B_bac.
IPR015933. Aconitase_B_HEAT-like_bac.
IPR015929. Aconitase_B_N_bac.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00330. Aconitase. 2 hits.
PF06434. Aconitase_2_N. 1 hit.
PF11791. Aconitase_B_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036687. AcnB. 1 hit.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
SSF74778. SSF74778. 1 hit.
TIGRFAMsiTIGR00117. acnB. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0K3Q9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLENYRAHVA ERAALGIPPL PLTAKQTAEL VELLKNPPAG EEQTLVELIT
60 70 80 90 100
YRVPAGVDDA AKVKASYLAA VALGKEKCAL ISRAKATELL GTMLGGYNIS
110 120 130 140 150
PLIELLDDAE VGTVAAEALK KTLLMFDAFH DVKEKADQGN ANAKAVLQSW
160 170 180 190 200
ADAEWFTSRP EVPQSLTITV FKVPGETNTD DLSPAPDATT RPDIPMHALA
210 220 230 240 250
MLKNKREGAA FQPEEDGKRG PVKFIESLKE KGHLVAYVGD VVGTGSSRKS
260 270 280 290 300
ATNSVLWFTG EDIPFIPNKR FGGVCLGNKI APIFYNTMED AGALPIELDV
310 320 330 340 350
SKMEMGDVVE LRPYEGKALK DGAVIAEFKV KSDVLFDEVR AGGRIPLIVG
360 370 380 390 400
RGLTAKAREA LGLAPSTLFR LPQNPADTGR GFTLAQKMVG RACGLPEGKG
410 420 430 440 450
IRPGTYCEPK MTSVGSQDTT GPMTRDELKD LACLGFSADL VMQSFCHTAA
460 470 480 490 500
YPKPVDVKTH HTLPEFISTR GGISLRPGDG VIHSWLNRML LPDTVGTGGD
510 520 530 540 550
SHTRFPIGIS FPAGSGLVAF AAATGVMPLD MPESVLVRFK GKMQPGVTLR
560 570 580 590 600
DLVNAIPLYA IKQGLLTVAK QGKKNIFSGR VLEIEGLPDL KVEQAFELSD
610 620 630 640 650
ASAERSAAGC TVRLNKDPII EYINSNITLL KWMIAQGYQD PRSLQRRIKA
660 670 680 690 700
MEAWLADPKL LEPDADAEYA AVIEIDLADV HEPIVACPND PDDVKTLSEV
710 720 730 740 750
AGAKIDEVFI GSCMTNIGHF RAASKLLEGK RDIPVKLWVA PPTKMDQKQL
760 770 780 790 800
TEEGHYGVFG TAGARTEMPG CSLCMGNQAQ VREGATVMST STRNFPNRLG
810 820 830 840 850
KNTNVYLGSA ELAAICSRLG RIPTKEEYMA DMGVLNANGD KIYKYMNFDQ
860
IEDFKEVADG VTV
Length:863
Mass (Da):93,126
Last modified:October 3, 2006 - v1
Checksum:i6624228948299E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260480 Genomic DNA. Translation: CAJ95365.1.
RefSeqiYP_728730.1. NC_008314.1.

Genome annotation databases

EnsemblBacteriaiCAJ95365; CAJ95365; H16_B0568.
GeneIDi4456731.
KEGGireh:H16_B0568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260480 Genomic DNA. Translation: CAJ95365.1 .
RefSeqi YP_728730.1. NC_008314.1.

3D structure databases

ProteinModelPortali Q0K3Q9.
SMRi Q0K3Q9. Positions 1-861.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_B0568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ95365 ; CAJ95365 ; H16_B0568 .
GeneIDi 4456731.
KEGGi reh:H16_B0568.

Phylogenomic databases

eggNOGi COG1049.
HOGENOMi HOG000205991.
KOi K01682.
OMAi PTRMDQQ.
OrthoDBi EOG6N944W.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00718 .
BioCyci CNEC381666:GJUJ-4275-MONOMER.

Family and domain databases

Gene3Di 3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProi IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR004406. Aconitase_B_bac.
IPR015933. Aconitase_B_HEAT-like_bac.
IPR015929. Aconitase_B_N_bac.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
Pfami PF00330. Aconitase. 2 hits.
PF06434. Aconitase_2_N. 1 hit.
PF11791. Aconitase_B_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF036687. AcnB. 1 hit.
SUPFAMi SSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
SSF74778. SSF74778. 1 hit.
TIGRFAMsi TIGR00117. acnB. 1 hit.
PROSITEi PS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337Imported.

Entry informationi

Entry nameiQ0K3Q9_CUPNH
AccessioniPrimary (citable) accession number: Q0K3Q9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3