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Q0K3N1

- ACDH2_CUPNH

UniProt

Q0K3N1 - ACDH2_CUPNH

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Protein

Acetaldehyde dehydrogenase 2

Gene

H16_B0596

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediateUniRule annotation
Binding sitei272 – 2721NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi161 – 1699NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-4303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:H16_B0596
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Acetaldehyde dehydrogenase 2PRO_0000387713Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_B0596.

Structurei

3D structure databases

ProteinModelPortaliQ0K3N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiTVIHARV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0K3N1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKIRCALIG PGNIGTDLLY KLRRSDILEP VWMVGVEPSS EGLARARELG
60 70 80 90 100
LKTTSDGIDG LLPHLEADDI RIAFDATSAY VHAEHSARLT ARGVRVIDLT
110 120 130 140 150
PAAIGPFCVP PVNLDAHIGS NEMNVNMVTC GGQATIPMVY AVSRVQPVAY
160 170 180 190 200
GEIVATVSSR SVGPGTRRNI DEFTRTTAGA IEAVGGARQG KAIIVINPAE
210 220 230 240 250
PPLIMRDTIH CLTDDAPDVA AITASVHDMI AEVRKYVPGY TLKNGPVFDG
260 270 280 290 300
KRVSIFLEVE GLGDYLPKYA GNLDIMTASA ARTAECIAAA MRAGSAQESA

NA
Length:302
Mass (Da):31,935
Last modified:October 3, 2006 - v1
Checksum:iC202DC8C45B3C124
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260480 Genomic DNA. Translation: CAJ95393.1.
RefSeqiYP_728758.1. NC_008314.1.

Genome annotation databases

EnsemblBacteriaiCAJ95393; CAJ95393; H16_B0596.
GeneIDi4456557.
KEGGireh:H16_B0596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM260480 Genomic DNA. Translation: CAJ95393.1 .
RefSeqi YP_728758.1. NC_008314.1.

3D structure databases

ProteinModelPortali Q0K3N1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_B0596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ95393 ; CAJ95393 ; H16_B0596 .
GeneIDi 4456557.
KEGGi reh:H16_B0596.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K18366.
OMAi TVIHARV.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci CNEC381666:GJUJ-4303-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiACDH2_CUPNH
AccessioniPrimary (citable) accession number: Q0K3N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3