Q0JMY1 (PRP2B_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly [ADP-ribose] polymerase 2-B
Short name=PARP-2-B
EC=2.4.2.30

Alternative name(s):
NAD(+) ADP-ribosyltransferase 2-B
Short name=ADPRT-2-B
Poly[ADP-ribose] synthase 2-B

Gene names

Name:	PARP2-B
Ordered Locus Names:	Os01g0351100, LOC_Os01g24920
ORF Names:	B1051E10.53, P0463A02.23

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	605 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks By similarity.
Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 PARP alpha-helical domain. Contains 1 PARP catalytic domain.
Sequence caution	The sequence BAF04897.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
PTM	ADP-ribosylation
Gene Ontology (GO)
Biological process	protein ADP-ribosylation Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 605	605	Poly [ADP-ribose] polymerase 2-B		PRO_0000260507
Regions
	Domain	250 – 370	121	PARP alpha-helical
	Domain	378 – 605	228	PARP catalytic
	Compositional bias	97 – 102	6	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q0JMY1 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: 9B49D0305E3D124E	FASTA	605	67,742
	10 20 30 40 50 60 MQMIGGEMWT AAGRRLHQQR DLHAILRTAH RRCCTRPIGG GLDAPAAPPG DLRTLSGVGM 70 80 90 100 110 120 LIHQFKALLA PKKIYPWRSS HLQSLEVRRL HTAPSNAAAA AAVTDGGDQD KTKSAKDDDG 130 140 150 160 170 180 DDKVQCKKEK IVTATKKGAA VLDQYIPDNI KTAYHVLQVG DEIYDATMNQ TNVGGNNNKF 190 200 210 220 230 240 YIIQALESDA GGNFMVYSRW GRVGTRDIHW SYRKGSHCYA HKYTWLEMDY GEADKETNKK 250 260 270 280 290 300 TSSITNQLEE TKLETRTASF ISLICDISMM KQQMVEIGYN ADKLPLGKLS KSTILKGYDV 310 320 330 340 350 360 LKRISNVISG ADTDRTQLEQ LTGEFYSVIP HDFGFKKMSE FIIDTPQKLK AKLEMVEALS 370 380 390 400 410 420 EIEIAIKLLE DDSSDQDHPL YARYKQFCCD FTPLEVDSEE YSMIKTYLTN THGKTHTGYT 430 440 450 460 470 480 VDIVQIFKVS RLGEMERFQK FASAGNRMLL WHGSRLTNWA GILSQGLRIA PPEAPISGFM 490 500 510 520 530 540 FGKGVYFADM FSKSANYCCA SEACKSGVML LCEVALGEMN ELLYGDFGAD NLPNGKLSTK 550 560 570 580 590 600 GVGQTEPNIA ESKITDDGMV IPLGKPEKVP SRRGSLMYNE YIVYNVDQIR MRYILNVNFN FKRWG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T. Nature 420:312-316(2002) [PubMed: 12447438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP003258 Genomic DNA. No translation available. AP003764 Genomic DNA. No translation available. AP008207 Genomic DNA. Translation: BAF04897.2. Sequence problems.
RefSeq	NP_001042983.2. NM_001049518.2.
UniGene	Os.79284.
3D structure databases
ProteinModelPortal	Q0JMY1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4326478.
KEGG	osa:4326478.
Phylogenomic databases
GeneTree	EPGT00070000029473.
HOGENOM	HBG713287.
PhylomeDB	Q0JMY1.
Family and domain databases
InterPro	IPR012317. Poly(ADP-ribose)pol_cat_dom. IPR004102. Poly(ADP-ribose)pol_reg_dom. IPR008893. WGR_domain. [Graphical view]
Gene3D	G3DSA:1.20.142.10. PARP_reg. 1 hit.
Pfam	PF00644. PARP. 1 hit. PF02877. PARP_reg. 1 hit. PF05406. WGR. 1 hit. [Graphical view]
SMART	SM00773. WGR. 1 hit. [Graphical view]
SUPFAM	SSF47587. PARP_reg. 1 hit. SSF142921. SSF142921. 1 hit.
PROSITE	PS51060. PARP_ALPHA_HD. 1 hit. PS51059. PARP_CATALYTIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRP2B_ORYSJ

Accession

Primary (citable) accession number: Q0JMY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	December 14, 2011
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program