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Q0JHP8

- LAC8_ORYSJ

UniProt

Q0JHP8 - LAC8_ORYSJ

Protein

Laccase-8

Gene

LAC8

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791Copper 1By similarity
    Metal bindingi81 – 811Copper 2By similarity
    Metal bindingi124 – 1241Copper 2By similarity
    Metal bindingi126 – 1261Copper 3By similarity
    Metal bindingi455 – 4551Copper 4By similarity
    Metal bindingi458 – 4581Copper 1By similarity
    Metal bindingi460 – 4601Copper 3By similarity
    Metal bindingi516 – 5161Copper 3By similarity
    Metal bindingi517 – 5171Copper 4By similarity
    Metal bindingi518 – 5181Copper 2By similarity
    Metal bindingi522 – 5221Copper 4By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW
    2. response to copper ion Source: EnsemblPlants/Gramene
    3. vegetative to reproductive phase transition of meristem Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-8 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 8
    Diphenol oxidase 8
    Urishiol oxidase 8
    Gene namesi
    Name:LAC8
    Ordered Locus Names:Os01g0850800, LOC_Os01g63200
    ORF Names:P0529H11.24
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 1

    Organism-specific databases

    GrameneiQ0JHP8.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 554533Laccase-8PRO_0000291893Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ0JHP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 145117Plastocyanin-like 1Add
    BLAST
    Domaini156 – 309154Plastocyanin-like 2Add
    BLAST
    Domaini411 – 537127Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    OMAiQAPCAPD.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0JHP8-1 [UniParc]FASTAAdd to Basket

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    MASAAMLVPL VLVLCTAAAS AAVVEHTFKV GGTKITQLCM NSVIYTANQQ    50
    LPGPTIEVTE GDTLVVHAVN DSPYPLSLHW HGVYQLRSGW NDGANKITQC 100
    PIQPSGNFTY RFNITGQEGT LWWHAHSSLL RATIYGALII KPRNGPSGYP 150
    FPEPYEEIPI LLGEWWNRNV DDVENDGYLT GLGPQISDAL TINGMPGDQN 200
    RCKGSAMYEV EVEYGKTCLL RIINAAVNVE LFFKVAGHTF TVVAADASYT 250
    KPYATDVIVI APGQTVDALM NTTASPGRYY MAAHVFDSKT VAVPFDQSTA 300
    TGIVKYKGVP NYAPAAMPSL PPHDDVVTAG RFYWSLTGLA RPSDPGVPTT 350
    VDHNMVVTFG LDQAPCAPNQ TKCSGFALVA AMNRNSFQFP DQKVSLLEAL 400
    YKGVPGVYSE DFPDFPPPMQ GFRKATAVKK VKYNDVVEVV LQSEQYSSTL 450
    GTENHPIHLH GFDFYLLAQG LGRFNPSMKS KYNLVDPQVR NTVAVPAGGW 500
    AVIRFMANNP GMWFMHCHLD AHLPLGLAMV FEVLNGPAPN LLPPPPVDHP 550
    KCHG 554
    Length:554
    Mass (Da):60,278
    Last modified:June 26, 2007 - v2
    Checksum:i8BBF740424ECC3F4
    GO

    Sequence cautioni

    The sequence BAD82649.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004072 Genomic DNA. Translation: BAD82649.1. Sequence problems.
    AP008207 Genomic DNA. Translation: BAF06730.2.
    RefSeqiNP_001044816.2. NM_001051351.2.
    UniGeneiOs.91169.

    Genome annotation databases

    EnsemblPlantsiOS01T0850800-00; OS01T0850800-00; OS01G0850800.
    GeneIDi4324803.
    KEGGiosa:4324803.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004072 Genomic DNA. Translation: BAD82649.1 . Sequence problems.
    AP008207 Genomic DNA. Translation: BAF06730.2 .
    RefSeqi NP_001044816.2. NM_001051351.2.
    UniGenei Os.91169.

    3D structure databases

    ProteinModelPortali Q0JHP8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS01T0850800-00 ; OS01T0850800-00 ; OS01G0850800 .
    GeneIDi 4324803.
    KEGGi osa:4324803.

    Organism-specific databases

    Gramenei Q0JHP8.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    OMAi QAPCAPD.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence and structure of rice chromosome 1."
      Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
      , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
      Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiLAC8_ORYSJ
    AccessioniPrimary (citable) accession number: Q0JHP8
    Secondary accession number(s): Q5N7A2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3