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Protein

Laccase-8

Gene

LAC8

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Copper 1By similarity1
Metal bindingi81Copper 2By similarity1
Metal bindingi124Copper 2By similarity1
Metal bindingi126Copper 3By similarity1
Metal bindingi455Copper 4By similarity1
Metal bindingi458Copper 1By similarity1
Metal bindingi460Copper 3By similarity1
Metal bindingi516Copper 3By similarity1
Metal bindingi517Copper 4By similarity1
Metal bindingi518Copper 2By similarity1
Metal bindingi522Copper 4By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-8 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 8
Diphenol oxidase 8
Urishiol oxidase 8
Gene namesi
Name:LAC8
Ordered Locus Names:Os01g0850800, LOC_Os01g63200
ORF Names:P0529H11.24
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000029189322 – 554Laccase-8Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Glycosylationi369N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ0JHP8.

Expressioni

Gene expression databases

GenevisibleiQ0JHP8. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g63200.1.

Structurei

3D structure databases

ProteinModelPortaliQ0JHP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 145Plastocyanin-like 1Add BLAST117
Domaini156 – 309Plastocyanin-like 2Add BLAST154
Domaini411 – 537Plastocyanin-like 3Add BLAST127

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ0JHP8.
OMAiDHPKCHG.
OrthoDBiEOG0936076C.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0JHP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAAMLVPL VLVLCTAAAS AAVVEHTFKV GGTKITQLCM NSVIYTANQQ
60 70 80 90 100
LPGPTIEVTE GDTLVVHAVN DSPYPLSLHW HGVYQLRSGW NDGANKITQC
110 120 130 140 150
PIQPSGNFTY RFNITGQEGT LWWHAHSSLL RATIYGALII KPRNGPSGYP
160 170 180 190 200
FPEPYEEIPI LLGEWWNRNV DDVENDGYLT GLGPQISDAL TINGMPGDQN
210 220 230 240 250
RCKGSAMYEV EVEYGKTCLL RIINAAVNVE LFFKVAGHTF TVVAADASYT
260 270 280 290 300
KPYATDVIVI APGQTVDALM NTTASPGRYY MAAHVFDSKT VAVPFDQSTA
310 320 330 340 350
TGIVKYKGVP NYAPAAMPSL PPHDDVVTAG RFYWSLTGLA RPSDPGVPTT
360 370 380 390 400
VDHNMVVTFG LDQAPCAPNQ TKCSGFALVA AMNRNSFQFP DQKVSLLEAL
410 420 430 440 450
YKGVPGVYSE DFPDFPPPMQ GFRKATAVKK VKYNDVVEVV LQSEQYSSTL
460 470 480 490 500
GTENHPIHLH GFDFYLLAQG LGRFNPSMKS KYNLVDPQVR NTVAVPAGGW
510 520 530 540 550
AVIRFMANNP GMWFMHCHLD AHLPLGLAMV FEVLNGPAPN LLPPPPVDHP

KCHG
Length:554
Mass (Da):60,278
Last modified:June 26, 2007 - v2
Checksum:i8BBF740424ECC3F4
GO

Sequence cautioni

The sequence BAD82649 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004072 Genomic DNA. Translation: BAD82649.1. Sequence problems.
AP008207 Genomic DNA. Translation: BAF06730.2.
AP014957 Genomic DNA. Translation: BAS75245.1.
RefSeqiXP_015632254.1. XM_015776768.1.

Genome annotation databases

EnsemblPlantsiOS01T0850800-00; OS01T0850800-00; OS01G0850800.
GeneIDi4324803.
GrameneiOS01T0850800-00; OS01T0850800-00; OS01G0850800.
KEGGiosa:4324803.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004072 Genomic DNA. Translation: BAD82649.1. Sequence problems.
AP008207 Genomic DNA. Translation: BAF06730.2.
AP014957 Genomic DNA. Translation: BAS75245.1.
RefSeqiXP_015632254.1. XM_015776768.1.

3D structure databases

ProteinModelPortaliQ0JHP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os01g63200.1.

Proteomic databases

PaxDbiQ0JHP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS01T0850800-00; OS01T0850800-00; OS01G0850800.
GeneIDi4324803.
GrameneiOS01T0850800-00; OS01T0850800-00; OS01G0850800.
KEGGiosa:4324803.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ0JHP8.
OMAiDHPKCHG.
OrthoDBiEOG0936076C.

Gene expression databases

GenevisibleiQ0JHP8. OS.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC8_ORYSJ
AccessioniPrimary (citable) accession number: Q0JHP8
Secondary accession number(s): A0A0P0VAG1, Q5N7A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 30, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.