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Protein

Proteasome subunit alpha type-7-B

Gene

PAD1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-OSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-OSA-5632684. Hedgehog 'on' state.
R-OSA-5689603. UCH proteinases.
R-OSA-5689880. Ub-specific processing proteases.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-OSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-OSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-7-B (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit D-2
20S proteasome subunit alpha-4-B
Gene namesi
Name:PAD1
Ordered Locus Names:Os09g0538200, LOC_Os09g36710
ORF Names:OsJ_028982, P0229B10.22, P0569E11.44
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241631 – 249Proteasome subunit alpha type-7-BAdd BLAST249

Proteomic databases

PaxDbiQ0J006.
PRIDEiQ0J006.

Expressioni

Gene expression databases

GenevisibleiQ0J006. OS.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

Protein-protein interaction databases

STRINGi39947.LOC_Os09g36710.1.

Structurei

3D structure databases

ProteinModelPortaliQ0J006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0183. Eukaryota.
ENOG410XP21. LUCA.
InParanoidiQ0J006.
KOiK02731.
OMAiEVAIMAP.
OrthoDBiEOG09360M33.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0J006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYDRAITV FSPDGHLFQV EYALEAVRKG NAAVGVRGSD TVVLGVEKKS
60 70 80 90 100
TPKLQDSRSV RKIASLDTHI ALACAGLKAD ARVLINRARV ECQSHRLTVE
110 120 130 140 150
DAVTVEYITR YIAGLQQKYT QSGGVRPFGL STLIVGFDPY TDKPALYQTD
160 170 180 190 200
PSGTFSAWKA NATGRNSNSM REFLEKNYKE TSGKETIKLA IRALLEVVES
210 220 230 240
GGKNIEIAVM TQKDGLRQLE EAEIDEYVAE IEAEKAAAEA AKKGAPKET
Length:249
Mass (Da):27,214
Last modified:October 3, 2006 - v1
Checksum:iD20D0B27143D976E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85Missing in BAA99540 (PubMed:10854779).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032061 mRNA. Translation: BAA99540.1.
AP006067 Genomic DNA. Translation: BAD34241.1.
AP006174 Genomic DNA. Translation: BAD34378.1.
AP008215 Genomic DNA. Translation: BAF25709.1.
AP014965 Genomic DNA. Translation: BAT09172.1.
CM000146 Genomic DNA. Translation: EAZ45499.1.
AK242072 mRNA. Translation: BAH01187.1.
RefSeqiXP_015651315.1. XM_015795829.1.
UniGeneiOs.3737.

Genome annotation databases

EnsemblPlantsiOS09T0538200-01; OS09T0538200-01; OS09G0538200.
GeneIDi4347710.
GrameneiOS09T0538200-01; OS09T0538200-01; OS09G0538200.
KEGGiosa:4347710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032061 mRNA. Translation: BAA99540.1.
AP006067 Genomic DNA. Translation: BAD34241.1.
AP006174 Genomic DNA. Translation: BAD34378.1.
AP008215 Genomic DNA. Translation: BAF25709.1.
AP014965 Genomic DNA. Translation: BAT09172.1.
CM000146 Genomic DNA. Translation: EAZ45499.1.
AK242072 mRNA. Translation: BAH01187.1.
RefSeqiXP_015651315.1. XM_015795829.1.
UniGeneiOs.3737.

3D structure databases

ProteinModelPortaliQ0J006.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os09g36710.1.

Proteomic databases

PaxDbiQ0J006.
PRIDEiQ0J006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS09T0538200-01; OS09T0538200-01; OS09G0538200.
GeneIDi4347710.
GrameneiOS09T0538200-01; OS09T0538200-01; OS09G0538200.
KEGGiosa:4347710.

Phylogenomic databases

eggNOGiKOG0183. Eukaryota.
ENOG410XP21. LUCA.
InParanoidiQ0J006.
KOiK02731.
OMAiEVAIMAP.
OrthoDBiEOG09360M33.

Enzyme and pathway databases

ReactomeiR-OSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-OSA-5632684. Hedgehog 'on' state.
R-OSA-5689603. UCH proteinases.
R-OSA-5689880. Ub-specific processing proteases.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-OSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-OSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

GenevisibleiQ0J006. OS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSA7B_ORYSJ
AccessioniPrimary (citable) accession number: Q0J006
Secondary accession number(s): B7F989
, O04861, Q69JF0, Q9LRI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.