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Protein

Proteasome subunit alpha type-7-B

Gene

PAD1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-OSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-OSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-OSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-OSA-5632684 Hedgehog 'on' state
R-OSA-5687128 MAPK6/MAPK4 signaling
R-OSA-5689603 UCH proteinases
R-OSA-5689880 Ub-specific processing proteases
R-OSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-OSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-OSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-7-B (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit D-2
20S proteasome subunit alpha-4-B
Gene namesi
Name:PAD1
Ordered Locus Names:Os09g0538200, LOC_Os09g36710
ORF Names:OsJ_028982, P0229B10.22, P0569E11.44
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241631 – 249Proteasome subunit alpha type-7-BAdd BLAST249

Proteomic databases

PaxDbiQ0J006
PRIDEiQ0J006

Expressioni

Gene expression databases

ExpressionAtlasiQ0J006 differential
GenevisibleiQ0J006 OS

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

Protein-protein interaction databases

STRINGi39947.LOC_Os09g36710.1

Structurei

3D structure databases

ProteinModelPortaliQ0J006
SMRiQ0J006
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0183 Eukaryota
ENOG410XP21 LUCA
InParanoidiQ0J006
KOiK02731
OMAiPYTQKPA
OrthoDBiEOG09360M33

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0J006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYDRAITV FSPDGHLFQV EYALEAVRKG NAAVGVRGSD TVVLGVEKKS
60 70 80 90 100
TPKLQDSRSV RKIASLDTHI ALACAGLKAD ARVLINRARV ECQSHRLTVE
110 120 130 140 150
DAVTVEYITR YIAGLQQKYT QSGGVRPFGL STLIVGFDPY TDKPALYQTD
160 170 180 190 200
PSGTFSAWKA NATGRNSNSM REFLEKNYKE TSGKETIKLA IRALLEVVES
210 220 230 240
GGKNIEIAVM TQKDGLRQLE EAEIDEYVAE IEAEKAAAEA AKKGAPKET
Length:249
Mass (Da):27,214
Last modified:October 3, 2006 - v1
Checksum:iD20D0B27143D976E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85Missing in BAA99540 (PubMed:10854779).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032061 mRNA Translation: BAA99540.1
AP006067 Genomic DNA Translation: BAD34241.1
AP006174 Genomic DNA Translation: BAD34378.1
AP008215 Genomic DNA Translation: BAF25709.1
AP014965 Genomic DNA Translation: BAT09172.1
CM000146 Genomic DNA Translation: EAZ45499.1
AK242072 mRNA Translation: BAH01187.1
RefSeqiXP_015651315.1, XM_015795829.1
UniGeneiOs.3737

Genome annotation databases

EnsemblPlantsiOs09t0538200-01; Os09t0538200-01; Os09g0538200
GeneIDi4347710
GrameneiOs09t0538200-01; Os09t0538200-01; Os09g0538200
KEGGiosa:4347710

Similar proteinsi

Entry informationi

Entry nameiPSA7B_ORYSJ
AccessioniPrimary (citable) accession number: Q0J006
Secondary accession number(s): B7F989
, O04861, Q69JF0, Q9LRI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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