ID   ADH2_ORYSJ              Reviewed;         379 AA.
AC   Q0ITW7; P18332; Q2R8Z2; Q9LLQ1;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 2.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Alcohol dehydrogenase 2;
DE            EC=1.1.1.1;
GN   Name=ADH2; Synonyms=DUPR11.1;
GN   OrderedLocusNames=Os11g0210500, LOC_Os11g10510;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Ehrhartoideae; Oryzeae; Oryza.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=20181732; PubMed=10715324; DOI=10.1105/tpc.12.3.381;
RA   Tarchini R., Biddle P., Wineland R., Tingey S., Rafalski A.;
RT   "The complete sequence of 340 kb of DNA around the rice Adh1-Adh2
RT   region reveals interrupted colinearity with maize chromosome 4.";
RL   Plant Cell 12:381-391(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease
RT   resistance genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=17210932; DOI=10.1101/gr.5509507;
RG   The rice annotation project (RAP);
RT   "Curated genome annotation of Oryza sativa ssp. japonica and
RT   comparative genome analysis with Arabidopsis thaliana.";
RL   Genome Res. 17:175-183(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   MEDLINE=22752273; PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone +
CC       NADH.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK102799; Type=Frameshift; Positions=369;
CC       Sequence=BAF27848.1; Type=Erroneous gene model prediction;
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DR   EMBL; AF172282; AAF34412.1; -; Genomic_DNA.
DR   EMBL; DP000010; ABA92034.1; -; Genomic_DNA.
DR   EMBL; AP008217; BAF27848.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AK102799; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001067485.1; -.
DR   UniGene; Os.8815; -.
DR   HSSP; P11766; 1M6H.
DR   GeneID; 4350054; -.
DR   KEGG; osa:4350054; -.
DR   Gramene; Q2R8Z2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004022; F:alcohol dehydrogenase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
FT   CHAIN         1    379       Alcohol dehydrogenase 2.
FT                                /FTId=PRO_0000160708.
FT   NP_BIND     202    207       NAD (By similarity).
FT   NP_BIND     295    297       NAD (By similarity).
FT   METAL        47     47       Zinc 1; catalytic (By similarity).
FT   METAL        69     69       Zinc 1; catalytic (By similarity).
FT   METAL        99     99       Zinc 2 (By similarity).
FT   METAL       102    102       Zinc 2 (By similarity).
FT   METAL       105    105       Zinc 2 (By similarity).
FT   METAL       113    113       Zinc 2 (By similarity).
FT   METAL       177    177       Zinc 1; catalytic (By similarity).
FT   BINDING     226    226       NAD (By similarity).
FT   BINDING     231    231       NAD (By similarity).
FT   BINDING     372    372       NAD (By similarity).
FT   CONFLICT     42     42       L -> I (in Ref. 5; AK102799).
SQ   SEQUENCE   379 AA;  41207 MW;  2DF98CF6B6BEE8EA CRC64;
     MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTALCHTD VYFWEAKGQT
     PVFPRILGHE AGGIVESVGE GVTELAPGDH VLPVFTGECK ECDHCKSEES NMCDLLRINV
     DRGVMIGDGK SRFTIKGKPI FHFVGTSTFS EYTVIHVGCL AKINPEAPLD KVCILSCGFS
     TGFGATVNVA KPKKGQTVAI FGLGAVGLAA MEGARLSGAS RIIGVDLNPA KFEQAKKFGC
     TDFVNPKDHS KPVHEVLIEM TNGGLDRAVE CTGNINAMIS CFECVHDGWG VAVLVGVPTK
     DDVFKTHPMN FLNEKTLKGT FFGNYKPRTD LPNVVELYMK KELELEKFIT HSVPFSEINT
     AFDLMLKGES LRCVMRMDE
//