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Q0ITW7 (ADH2_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase 2
EC=1.1.1.1
Gene names
Name:ADH2
Synonyms:DUPR11.1
Ordered Locus Names:Os11g0210500, LOC_Os11g10510
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Sequence caution

The sequence AK102799 differs from that shown. Reason: Frameshift at position 369.

The sequence BAF27848.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Molecular functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Alcohol dehydrogenase 2
PRO_0000160708

Regions

Nucleotide binding202 – 2076NAD By similarity
Nucleotide binding295 – 2973NAD By similarity

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding691Zinc 1; catalytic By similarity
Metal binding991Zinc 2 By similarity
Metal binding1021Zinc 2 By similarity
Metal binding1051Zinc 2 By similarity
Metal binding1131Zinc 2 By similarity
Metal binding1771Zinc 1; catalytic By similarity
Binding site2261NAD By similarity
Binding site2311NAD By similarity
Binding site3721NAD By similarity

Experimental info

Sequence conflict421L → I in AK102799. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q0ITW7 [UniParc].

Last modified June 12, 2007. Version 2.
Checksum: 2DF98CF6B6BEE8EA

FASTA37941,207
        10         20         30         40         50         60 
MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTALCHTD VYFWEAKGQT 

        70         80         90        100        110        120 
PVFPRILGHE AGGIVESVGE GVTELAPGDH VLPVFTGECK ECDHCKSEES NMCDLLRINV 

       130        140        150        160        170        180 
DRGVMIGDGK SRFTIKGKPI FHFVGTSTFS EYTVIHVGCL AKINPEAPLD KVCILSCGFS 

       190        200        210        220        230        240 
TGFGATVNVA KPKKGQTVAI FGLGAVGLAA MEGARLSGAS RIIGVDLNPA KFEQAKKFGC 

       250        260        270        280        290        300 
TDFVNPKDHS KPVHEVLIEM TNGGLDRAVE CTGNINAMIS CFECVHDGWG VAVLVGVPTK 

       310        320        330        340        350        360 
DDVFKTHPMN FLNEKTLKGT FFGNYKPRTD LPNVVELYMK KELELEKFIT HSVPFSEINT 

       370 
AFDLMLKGES LRCVMRMDE

« Hide

References

« Hide 'large scale' references
[1]"The complete sequence of 340 kb of DNA around the rice Adh1-Adh2 region reveals interrupted colinearity with maize chromosome 4."
Tarchini R., Biddle P., Wineland R., Tingey S., Rafalski A.
Plant Cell 12:381-391(2000) [PubMed: 10715324] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
The rice chromosomes 11 and 12 sequencing consortia
BMC Biol. 3:20-20(2005) [PubMed: 16188032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed: 16100779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[4]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[5]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed: 12869764] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF172282 Genomic DNA. Translation: AAF34412.1.
DP000010 Genomic DNA. Translation: ABA92034.1.
AP008217 Genomic DNA. Translation: BAF27848.1. Sequence problems.
AK102799 mRNA. No translation available.
RefSeqNP_001067485.1. NM_001074017.1.
UniGeneOs.8815.

3D structure databases

ProteinModelPortalQ0ITW7.
SMRQ0ITW7. Positions 4-377.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsLOC_Os11g10510.1; LOC_Os11g10510.1; LOC_Os11g10510.
GeneID4350054.
KEGGosa:4350054.

Organism-specific databases

GrameneQ2R8Z2.

Phylogenomic databases

HOGENOMHBG753318.
OMAPWSIETI.
ProtClustDBCLSN2717044.

Family and domain databases

InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00001.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 2 hits.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADH2_ORYSJ
AccessionPrimary (citable) accession number: Q0ITW7
Secondary accession number(s): P18332, Q2R8Z2, Q9LLQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families

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