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Protein

Laccase-22

Gene

LAC22

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86Copper 1By similarity1
Metal bindingi88Copper 2By similarity1
Metal bindingi131Copper 2By similarity1
Metal bindingi133Copper 3By similarity1
Metal bindingi465Copper 4By similarity1
Metal bindingi468Copper 1By similarity1
Metal bindingi470Copper 3By similarity1
Metal bindingi527Copper 3By similarity1
Metal bindingi528Copper 4By similarity1
Metal bindingi529Copper 2By similarity1
Metal bindingi533Copper 4By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-22 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 22
Diphenol oxidase 22
Urishiol oxidase 22
Gene namesi
Name:LAC22
Ordered Locus Names:Os11g0708100, LOC_Os11g48060
ORF Names:OsJ_033548
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000029190926 – 564Laccase-22Add BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi331N-linked (GlcNAc...)Sequence analysis1
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi389N-linked (GlcNAc...)Sequence analysis1
Glycosylationi424N-linked (GlcNAc...)Sequence analysis1
Glycosylationi437N-linked (GlcNAc...)Sequence analysis1
Glycosylationi447N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ0IQU1.
PRIDEiQ0IQU1.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os11g48060.1.

Structurei

3D structure databases

ProteinModelPortaliQ0IQU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 152Plastocyanin-like 1Add BLAST117
Domaini162 – 314Plastocyanin-like 2Add BLAST153
Domaini414 – 548Plastocyanin-like 3Add BLAST135

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ0IQU1.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0IQU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLPESRRL SLLLMAACFL LQALSAHAIT RHYKFNVVMR NMTRLCSTKP
60 70 80 90 100
ILTVNGKFPG PTLYAREGDN VLVKVVNHVA HNVTIHWHGV RQIRTGWYDG
110 120 130 140 150
PAYITQCPIQ PGSSFLYNFT ITGQRGTLLW HAHINWLRAT VHGAIVILPK
160 170 180 190 200
LGVPYPFPAP HKEAVIVLGE WWKEDTETVI NQAMQLGVGP NISDSHTING
210 220 230 240 250
HPGPLSECAS SQDGFKLSVE NGKTYMLRII NAALNDDLFF KVAGHELTVV
260 270 280 290 300
EVDAVYTKPF KTDTLLITPG QTTNVLVRAN QGAGRYLLSV SPFMDAPVQV
310 320 330 340 350
DNKTGTATLH YANTVSSSMA SLTLVKPPPQ NATHIVSKFT DSLHSLNSKE
360 370 380 390 400
YPANVPQTVD HSLLLTVGVG VNPCPSCING TRVVGTINNV TFIMPSTPIL
410 420 430 440 450
QAHYYNIPGV FTEDFPATPL HKFNYTGSGP KNLQTMNGTR VYRLPYNASV
460 470 480 490 500
QVVLQDTGII SPESHPIHLH GFNFFVVGKG VGNYNPRTSP STFNLIDPIE
510 520 530 540 550
RNTIGVPTGG WTAIRFRSDN PGVWFMHCHF EVHTSWGLKM AFVVDNGKRP
560
SETLIPPPKD LPQC
Length:564
Mass (Da):62,042
Last modified:June 26, 2007 - v2
Checksum:iC88700E8EDA0C0D2
GO

Sequence cautioni

The sequence BAF28924 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133008 Genomic DNA. Translation: AAX95423.1.
DP000010 Genomic DNA. Translation: ABA95532.1.
AP008217 Genomic DNA. Translation: BAF28924.1. Sequence problems.
AP014967 Genomic DNA. No translation available.
CM000148 Genomic DNA. Translation: EAZ19339.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133008 Genomic DNA. Translation: AAX95423.1.
DP000010 Genomic DNA. Translation: ABA95532.1.
AP008217 Genomic DNA. Translation: BAF28924.1. Sequence problems.
AP014967 Genomic DNA. No translation available.
CM000148 Genomic DNA. Translation: EAZ19339.1.

3D structure databases

ProteinModelPortaliQ0IQU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os11g48060.1.

Proteomic databases

PaxDbiQ0IQU1.
PRIDEiQ0IQU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ0IQU1.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC22_ORYSJ
AccessioniPrimary (citable) accession number: Q0IQU1
Secondary accession number(s): Q53NW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: October 5, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.