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Q0IQU1 (LAC22_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Laccase-22
EC=1.10.3.2
Alternative name(s):
Benzenediol:oxygen oxidoreductase 22
Diphenol oxidase 22
Urishiol oxidase 22
Gene names
Name:LAC22
Ordered Locus Names:Os11g0708100, LOC_Os11g48060
ORF Names:OsJ_033548
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activity

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Subcellular location

Secreted › extracellular space › apoplast Potential.

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

Sequence caution

The sequence BAF28924.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processLignin degradation
   Cellular componentApoplast
Secreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentapoplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncopper ion binding

Inferred from electronic annotation. Source: InterPro

hydroquinone:oxygen oxidoreductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 564539Laccase-22
PRO_0000291909

Regions

Domain36 – 152117Plastocyanin-like 1
Domain162 – 314153Plastocyanin-like 2
Domain414 – 548135Plastocyanin-like 3

Sites

Metal binding861Copper 1 By similarity
Metal binding881Copper 2 By similarity
Metal binding1311Copper 2 By similarity
Metal binding1331Copper 3 By similarity
Metal binding4651Copper 4 By similarity
Metal binding4681Copper 1 By similarity
Metal binding4701Copper 3 By similarity
Metal binding5271Copper 3 By similarity
Metal binding5281Copper 4 By similarity
Metal binding5291Copper 2 By similarity
Metal binding5331Copper 4 By similarity

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation3891N-linked (GlcNAc...) Potential
Glycosylation4241N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation4471N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0IQU1 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: C88700E8EDA0C0D2

FASTA56462,042
        10         20         30         40         50         60 
MAVLPESRRL SLLLMAACFL LQALSAHAIT RHYKFNVVMR NMTRLCSTKP ILTVNGKFPG 

        70         80         90        100        110        120 
PTLYAREGDN VLVKVVNHVA HNVTIHWHGV RQIRTGWYDG PAYITQCPIQ PGSSFLYNFT 

       130        140        150        160        170        180 
ITGQRGTLLW HAHINWLRAT VHGAIVILPK LGVPYPFPAP HKEAVIVLGE WWKEDTETVI 

       190        200        210        220        230        240 
NQAMQLGVGP NISDSHTING HPGPLSECAS SQDGFKLSVE NGKTYMLRII NAALNDDLFF 

       250        260        270        280        290        300 
KVAGHELTVV EVDAVYTKPF KTDTLLITPG QTTNVLVRAN QGAGRYLLSV SPFMDAPVQV 

       310        320        330        340        350        360 
DNKTGTATLH YANTVSSSMA SLTLVKPPPQ NATHIVSKFT DSLHSLNSKE YPANVPQTVD 

       370        380        390        400        410        420 
HSLLLTVGVG VNPCPSCING TRVVGTINNV TFIMPSTPIL QAHYYNIPGV FTEDFPATPL 

       430        440        450        460        470        480 
HKFNYTGSGP KNLQTMNGTR VYRLPYNASV QVVLQDTGII SPESHPIHLH GFNFFVVGKG 

       490        500        510        520        530        540 
VGNYNPRTSP STFNLIDPIE RNTIGVPTGG WTAIRFRSDN PGVWFMHCHF EVHTSWGLKM 

       550        560 
AFVVDNGKRP SETLIPPPKD LPQC

« Hide

References

« Hide 'large scale' references
[1]"The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
The rice chromosomes 11 and 12 sequencing consortia
BMC Biol. 3:20-20(2005) [PubMed: 16188032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed: 16100779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[4]"The genomes of Oryza sativa: a history of duplications."
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. expand/collapse author list , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC133008 Genomic DNA. Translation: AAX95423.1.
DP000010 Genomic DNA. Translation: ABA95532.1.
AP008217 Genomic DNA. Translation: BAF28924.1. Sequence problems.
CM000148 Genomic DNA. Translation: EAZ19339.1.

3D structure databases

ProteinModelPortalQ0IQU1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneQ53NW2.

Phylogenomic databases

GeneTreeEPGT00050000000260.

Family and domain databases

InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
Gene3DG3DSA:2.60.40.420. Cupredoxin. 3 hits.
PANTHERPTHR11709:SF9. PTHR11709:SF9. 1 hit.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMSSF49503. Cupredoxin. 3 hits.
TIGRFAMsTIGR03389. Laccase. 1 hit.
PROSITEPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLAC22_ORYSJ
AccessionPrimary (citable) accession number: Q0IQU1
Secondary accession number(s): Q53NW2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 16, 2011
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents