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Q0IP28

- LAC25_ORYSJ

UniProt

Q0IP28 - LAC25_ORYSJ

Protein

Laccase-25

Gene

LAC25

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi81 – 811Copper 1By similarity
    Metal bindingi83 – 831Copper 2By similarity
    Metal bindingi126 – 1261Copper 2By similarity
    Metal bindingi128 – 1281Copper 3By similarity
    Metal bindingi477 – 4771Copper 4By similarity
    Metal bindingi480 – 4801Copper 1By similarity
    Metal bindingi482 – 4821Copper 3By similarity
    Metal bindingi539 – 5391Copper 3By similarity
    Metal bindingi540 – 5401Copper 4By similarity
    Metal bindingi541 – 5411Copper 2By similarity
    Metal bindingi545 – 5451Copper 4By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-25 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 25
    Diphenol oxidase 25
    Urishiol oxidase 25
    Gene namesi
    Name:LAC25
    Ordered Locus Names:Os12g0259800, LOC_Os12g15920
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 12

    Organism-specific databases

    GrameneiQ0IP28.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 577555Laccase-25PRO_0000291912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os12g15920.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0IP28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 147118Plastocyanin-like 1Add
    BLAST
    Domaini158 – 313156Plastocyanin-like 2Add
    BLAST
    Domaini423 – 560138Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 4 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0IP28-1 [UniParc]FASTAAdd to Basket

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    MTLHWSLLLF IAIALVSSVA QAAVVEHTFN VGNFSISQLC QPPLIITAVN    50
    GQLPGPTIYA REGDTVVVHL VNTSPYSMTL HWHGVLQRGT PWADGPAMVT 100
    QCPVQPGGNY TYRFNVDGQE GTLWWHAHVS FHRATVYGAL VIRPRGGAKA 150
    YPFPKPDKEH VVILGEWWNA TVYDMERMAF LTGIPAPHAD AYTINGKPGD 200
    FYNCSAPNQT AKFEVRQNGT YLLRIINAGM NTPLFFKVAK HRLTVVGADA 250
    CYTKPYKTDV VVVSPGQTVD ALMVASAAVG RYYMAASPYD SAIPQGPPFS 300
    DTTATAILQY AGARRKTVRW RPPVLPRRPP VNDTATAHRF FSGMTALLRH 350
    GKPSAVPLAV DTHMYVTVGL GVSLCQPEQL LCNRSAPPVF SSSMNNASFV 400
    VPKNTSLLEA HFRREPAGVY TRDFPDTPPV VFDYTGDESD NATMQFTTKS 450
    TKVKTLRYNE TVEMVLQNTR LIAKESHPMH IHGFNFFILA QGFGNYDKRR 500
    AERRFNLVDP QERNTIAVPT GGWAVIRFVA DNPGMWYMHC HFDAHISLGL 550
    AMVLEVLDGP TPETSVPPPP ADLPRCS 577
    Length:577
    Mass (Da):63,680
    Last modified:October 3, 2006 - v1
    Checksum:iCA6FE93780DD7AA1
    GO

    Sequence cautioni

    The sequence ABA97328.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000011 Genomic DNA. Translation: ABA97328.1. Sequence problems.
    AP008218 Genomic DNA. Translation: BAF29537.1.
    RefSeqiNP_001066518.1. NM_001073050.1.
    UniGeneiOs.78608.

    Genome annotation databases

    GeneIDi4351917.
    KEGGiosa:4351917.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000011 Genomic DNA. Translation: ABA97328.1 . Sequence problems.
    AP008218 Genomic DNA. Translation: BAF29537.1 .
    RefSeqi NP_001066518.1. NM_001073050.1.
    UniGenei Os.78608.

    3D structure databases

    ProteinModelPortali Q0IP28.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os12g15920.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4351917.
    KEGGi osa:4351917.

    Organism-specific databases

    Gramenei Q0IP28.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 4 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
      The rice chromosomes 11 and 12 sequencing consortia
      BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiLAC25_ORYSJ
    AccessioniPrimary (citable) accession number: Q0IP28
    Secondary accession number(s): Q2QUK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3