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Reviewed, UniProtKB/Swiss-Prot Q0IP28 (LAC25_ORYSJ)

Last modified February 9, 2010. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Laccase-25
    EC=1.10.3.2
Alternative name(s):
    Benzenediol:oxygen oxidoreductase 25
    Urishiol oxidase 25
    Diphenol oxidase 25
Gene names
Name: LAC25
Ordered Locus Names: Os12g0259800, LOC_Os12g15920
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

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Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activity

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Subcellular location

Secreted › extracellular space › apoplast Potential.

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

Sequence caution

The sequence ABA97328.1 differs from that shown. Reason: Erroneous gene model prediction.

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Ontologies

Keywords
   Biological processLignin degradation
   Cellular componentApoplast
Secreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentapoplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncopper ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

laccase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 577555Laccase-25
PRO_0000291912

Regions

Domain30 – 147118Plastocyanin-like 1
Domain158 – 313156Plastocyanin-like 2
Domain423 – 560138Plastocyanin-like 3

Sites

Metal binding811Copper 1 By similarity
Metal binding831Copper 2 By similarity
Metal binding1261Copper 2 By similarity
Metal binding1281Copper 3 By similarity
Metal binding4771Copper 4 By similarity
Metal binding4801Copper 1 By similarity
Metal binding4821Copper 3 By similarity
Metal binding5391Copper 3 By similarity
Metal binding5401Copper 4 By similarity
Metal binding5411Copper 2 By similarity
Metal binding5451Copper 4 By similarity

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation2031N-linked (GlcNAc...) Potential
Glycosylation2081N-linked (GlcNAc...) Potential
Glycosylation2181N-linked (GlcNAc...) Potential
Glycosylation3321N-linked (GlcNAc...) Potential
Glycosylation3831N-linked (GlcNAc...) Potential
Glycosylation3961N-linked (GlcNAc...) Potential
Glycosylation4041N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation4591N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q0IP28-1 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: CA6FE93780DD7AA1

FASTA57763,680
        10         20         30         40         50         60 
MTLHWSLLLF IAIALVSSVA QAAVVEHTFN VGNFSISQLC QPPLIITAVN GQLPGPTIYA 

        70         80         90        100        110        120 
REGDTVVVHL VNTSPYSMTL HWHGVLQRGT PWADGPAMVT QCPVQPGGNY TYRFNVDGQE 

       130        140        150        160        170        180 
GTLWWHAHVS FHRATVYGAL VIRPRGGAKA YPFPKPDKEH VVILGEWWNA TVYDMERMAF 

       190        200        210        220        230        240 
LTGIPAPHAD AYTINGKPGD FYNCSAPNQT AKFEVRQNGT YLLRIINAGM NTPLFFKVAK 

       250        260        270        280        290        300 
HRLTVVGADA CYTKPYKTDV VVVSPGQTVD ALMVASAAVG RYYMAASPYD SAIPQGPPFS 

       310        320        330        340        350        360 
DTTATAILQY AGARRKTVRW RPPVLPRRPP VNDTATAHRF FSGMTALLRH GKPSAVPLAV 

       370        380        390        400        410        420 
DTHMYVTVGL GVSLCQPEQL LCNRSAPPVF SSSMNNASFV VPKNTSLLEA HFRREPAGVY 

       430        440        450        460        470        480 
TRDFPDTPPV VFDYTGDESD NATMQFTTKS TKVKTLRYNE TVEMVLQNTR LIAKESHPMH 

       490        500        510        520        530        540 
IHGFNFFILA QGFGNYDKRR AERRFNLVDP QERNTIAVPT GGWAVIRFVA DNPGMWYMHC 

       550        560        570 
HFDAHISLGL AMVLEVLDGP TPETSVPPPP ADLPRCS

« Hide

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References

« Hide 'large scale' references
[1]"The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
The rice chromosomes 11 and 12 sequencing consortia
BMC Biol. 3:20-20(2005) [PubMed: 16188032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed: 16100779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana."
The rice annotation project (RAP)
Genome Res. 17:175-183(2007) [PubMed: 17210932] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DP000011 Genomic DNA. Translation: ABA97328.1. Sequence problems.
AP008218 Genomic DNA. Translation: BAF29537.1.
RefSeqNP_001066518.1.
UniGeneOs.78608

3D structure databases

SMRQ0IP28. Positions 22-577.
ModBaseSearch...

Genome annotation databases

GeneID4351917.
GenomeReviewsGene locus LAC25 in contig AP008218_GR.
KEGGosa:4351917.

Organism-specific databases

GrameneQ2QUK8.

Phylogenomic databases

HOGENOMHBG749556.
PhylomeDBQ0IP28.

Family and domain databases

InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
Gene3DG3DSA:2.60.40.420. Cupredoxin. 3 hits.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR03389. laccase. 1 hit.
PROSITEPS00079. MULTICOPPER_OXIDASE1. False negative.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLAC25_ORYSJ
AccessionPrimary (citable) accession number: Q0IP28
Secondary accession number(s): Q2QUK8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 3, 2006
Last modified: February 9, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents