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Protein

Laccase-25

Gene

LAC25

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Copper 1By similarity1
Metal bindingi83Copper 2By similarity1
Metal bindingi126Copper 2By similarity1
Metal bindingi128Copper 3By similarity1
Metal bindingi477Copper 4By similarity1
Metal bindingi480Copper 1By similarity1
Metal bindingi482Copper 3By similarity1
Metal bindingi539Copper 3By similarity1
Metal bindingi540Copper 4By similarity1
Metal bindingi541Copper 2By similarity1
Metal bindingi545Copper 4By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-25 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 25
Diphenol oxidase 25
Urishiol oxidase 25
Gene namesi
Name:LAC25
Ordered Locus Names:Os12g0259800, LOC_Os12g15920
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029191223 – 577Laccase-25Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1
Glycosylationi332N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1
Glycosylationi396N-linked (GlcNAc...)Sequence analysis1
Glycosylationi404N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi459N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ0IP28.
PRIDEiQ0IP28.

Expressioni

Gene expression databases

GenevisibleiQ0IP28. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os12g15920.1.

Structurei

3D structure databases

ProteinModelPortaliQ0IP28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 147Plastocyanin-like 1Add BLAST118
Domaini158 – 313Plastocyanin-like 2Add BLAST156
Domaini423 – 560Plastocyanin-like 3Add BLAST138

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ0IP28.
OrthoDBiEOG093605LR.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0IP28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLHWSLLLF IAIALVSSVA QAAVVEHTFN VGNFSISQLC QPPLIITAVN
60 70 80 90 100
GQLPGPTIYA REGDTVVVHL VNTSPYSMTL HWHGVLQRGT PWADGPAMVT
110 120 130 140 150
QCPVQPGGNY TYRFNVDGQE GTLWWHAHVS FHRATVYGAL VIRPRGGAKA
160 170 180 190 200
YPFPKPDKEH VVILGEWWNA TVYDMERMAF LTGIPAPHAD AYTINGKPGD
210 220 230 240 250
FYNCSAPNQT AKFEVRQNGT YLLRIINAGM NTPLFFKVAK HRLTVVGADA
260 270 280 290 300
CYTKPYKTDV VVVSPGQTVD ALMVASAAVG RYYMAASPYD SAIPQGPPFS
310 320 330 340 350
DTTATAILQY AGARRKTVRW RPPVLPRRPP VNDTATAHRF FSGMTALLRH
360 370 380 390 400
GKPSAVPLAV DTHMYVTVGL GVSLCQPEQL LCNRSAPPVF SSSMNNASFV
410 420 430 440 450
VPKNTSLLEA HFRREPAGVY TRDFPDTPPV VFDYTGDESD NATMQFTTKS
460 470 480 490 500
TKVKTLRYNE TVEMVLQNTR LIAKESHPMH IHGFNFFILA QGFGNYDKRR
510 520 530 540 550
AERRFNLVDP QERNTIAVPT GGWAVIRFVA DNPGMWYMHC HFDAHISLGL
560 570
AMVLEVLDGP TPETSVPPPP ADLPRCS
Length:577
Mass (Da):63,680
Last modified:October 3, 2006 - v1
Checksum:iCA6FE93780DD7AA1
GO

Sequence cautioni

The sequence ABA97328 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000011 Genomic DNA. Translation: ABA97328.1. Sequence problems.
AP008218 Genomic DNA. Translation: BAF29537.1.
AP014968 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000011 Genomic DNA. Translation: ABA97328.1. Sequence problems.
AP008218 Genomic DNA. Translation: BAF29537.1.
AP014968 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ0IP28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os12g15920.1.

Proteomic databases

PaxDbiQ0IP28.
PRIDEiQ0IP28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ0IP28.
OrthoDBiEOG093605LR.

Gene expression databases

GenevisibleiQ0IP28. OS.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC25_ORYSJ
AccessioniPrimary (citable) accession number: Q0IP28
Secondary accession number(s): Q2QUK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 3, 2006
Last modified: October 5, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.