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Protein

Receptor protein-tyrosine kinase

Gene

FGFR3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionReceptorSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:FGFR3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 70HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28129

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 435Protein kinaseInterPro annotationAdd BLAST290

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
HOVERGENiHBG000345
KOiK05094

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Fragment.

Q0IJ44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TRALPEDAGE YTCLAGNSIG FSHHSAWLVV LPAEEELVEA DEAGSVYAGI
60 70 80 90 100
LSYGVGFFLF ILVVAAVTLC RLRSPPKKGL GSPTVHKISR FPLKRQVSLE
110 120 130 140 150
SNASMSSNTP LVRIARLSSG EGPTLANVSE LELPADPKWE LSRARLTLGK
160 170 180 190 200
PLGEGCFGQV VMAEAIGIDK DRAAKPVTVA VKMLKDDATD KDLSDLVSEM
210 220 230 240 250
EMMKMIGKHK NIINLLGACT QGGPLYVLVE YAAKGNLREF LRARRPPGLD
260 270 280 290 300
YSFDTCKPPE EQLTFKDLVS CAYQVARGME YLASQKCIHR DLAARNVLVT
310 320 330 340 350
EDNVMKIADF GLARDVHNLD YYKKTTNGRL PVKWMAPEAL FDRVYTHQSD
360 370 380 390 400
VWSFGVLLWE IFTLGGSPYP GIPVEELFKL LKEGHRMDKP ANCTHDLYMI
410 420 430 440 450
MRECWHAAPS QRPTFKQLVE DLDRVLTVTS TDEYLDLSAP FEQYSPGGQD
460 470 480
TPSSSSSGDD SVFAHDLLPP APPSSGGSRT
Length:480
Mass (Da):52,772
Last modified:October 3, 2006 - v1
Checksum:i76D658CFF5765DFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121175 mRNA Translation: AAI21176.1
BC128610 mRNA Translation: AAI28611.1
RefSeqiNP_000133.1, NM_000142.4
NP_001156685.1, NM_001163213.1
NP_075254.1, NM_022965.3
UniGeneiHs.1420

Genome annotation databases

GeneIDi2261
KEGGihsa:2261

Similar proteinsi

Entry informationi

Entry nameiQ0IJ44_HUMAN
AccessioniPrimary (citable) accession number: Q0IJ44
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health